Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus.
BACKGROUND: Aedes albopictus, the Asian tiger mosquito, is a vector of several arboviruses including dengue and chikungunya, and is also a significant nuisance mosquito. It is one of the most invasive of mosquitoes with a relentlessly increasing geographic distribution. Conventional control methods...
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ftdoajarticles:oai:doaj.org/article:4b5ac141faca46f0bf7c63f8af4cbb6a 2023-05-15T15:06:33+02:00 Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus. Geneviève M C Labbé Sarah Scaife Siân A Morgan Zoë H Curtis Luke Alphey 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001724 https://doaj.org/article/4b5ac141faca46f0bf7c63f8af4cbb6a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3393675?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001724 https://doaj.org/article/4b5ac141faca46f0bf7c63f8af4cbb6a PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1724 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001724 2022-12-30T22:26:16Z BACKGROUND: Aedes albopictus, the Asian tiger mosquito, is a vector of several arboviruses including dengue and chikungunya, and is also a significant nuisance mosquito. It is one of the most invasive of mosquitoes with a relentlessly increasing geographic distribution. Conventional control methods have so far failed to control Ae. albopictus adequately. Novel genetics-based strategies offer a promising alternative or aid towards efficient control of this mosquito. METHODOLOGY/PRINCIPAL FINDINGS: We describe here the isolation, characterisation and use of the Ae. albopictus Actin-4 gene to drive a dominant lethal gene in the indirect flight muscles of Ae. albopictus, thus inducing a conditional female-specific late-acting flightless phenotype. We also show that in this context, the Actin-4 regulatory regions from both Ae. albopictus and Ae. aegypti can be used to provide conditional female-specific flightlessness in either species. CONCLUSION/SIGNIFICANCE: With the disease-transmitting females incapacitated, the female flightless phenotype encompasses a genetic sexing mechanism and would be suitable for controlling Ae. albopictus using a male-only release approach as part of an integrated pest management strategy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 7 e1724 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Geneviève M C Labbé Sarah Scaife Siân A Morgan Zoë H Curtis Luke Alphey Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Aedes albopictus, the Asian tiger mosquito, is a vector of several arboviruses including dengue and chikungunya, and is also a significant nuisance mosquito. It is one of the most invasive of mosquitoes with a relentlessly increasing geographic distribution. Conventional control methods have so far failed to control Ae. albopictus adequately. Novel genetics-based strategies offer a promising alternative or aid towards efficient control of this mosquito. METHODOLOGY/PRINCIPAL FINDINGS: We describe here the isolation, characterisation and use of the Ae. albopictus Actin-4 gene to drive a dominant lethal gene in the indirect flight muscles of Ae. albopictus, thus inducing a conditional female-specific late-acting flightless phenotype. We also show that in this context, the Actin-4 regulatory regions from both Ae. albopictus and Ae. aegypti can be used to provide conditional female-specific flightlessness in either species. CONCLUSION/SIGNIFICANCE: With the disease-transmitting females incapacitated, the female flightless phenotype encompasses a genetic sexing mechanism and would be suitable for controlling Ae. albopictus using a male-only release approach as part of an integrated pest management strategy. |
format |
Article in Journal/Newspaper |
author |
Geneviève M C Labbé Sarah Scaife Siân A Morgan Zoë H Curtis Luke Alphey |
author_facet |
Geneviève M C Labbé Sarah Scaife Siân A Morgan Zoë H Curtis Luke Alphey |
author_sort |
Geneviève M C Labbé |
title |
Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus. |
title_short |
Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus. |
title_full |
Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus. |
title_fullStr |
Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus. |
title_full_unstemmed |
Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus. |
title_sort |
female-specific flightless (fsridl) phenotype for control of aedes albopictus. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001724 https://doaj.org/article/4b5ac141faca46f0bf7c63f8af4cbb6a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1724 (2012) |
op_relation |
http://europepmc.org/articles/PMC3393675?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001724 https://doaj.org/article/4b5ac141faca46f0bf7c63f8af4cbb6a |
op_doi |
https://doi.org/10.1371/journal.pntd.0001724 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
6 |
container_issue |
7 |
container_start_page |
e1724 |
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1766338132520730624 |