Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis.
Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells in vitro, we demonstrate that the expression of IL-32 isoforms is dependent o...
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ftdoajarticles:oai:doaj.org/article:4b4f16bfe8924b5c958c7729a0749dd7 2023-05-15T15:05:27+02:00 Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis. Jéssica Cristina Dos Santos Valéria Bernadete Leite Quixabeira Muriel Vilela Teodoro Silva Michelle S M A Damen Kiki Schraa Martin Jaeger Marije Oosting Samuel T Keating Miriam Leandro Dorta Sebastião Alves Pinto Fernanda Bugalho Duarte Ledice Inácia de Araújo Pereira Mihai G Netea Fátima Ribeiro-Dias Leo A B Joosten 2020-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008029 https://doaj.org/article/4b4f16bfe8924b5c958c7729a0749dd7 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008029 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008029 https://doaj.org/article/4b4f16bfe8924b5c958c7729a0749dd7 PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0008029 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008029 2022-12-31T05:07:34Z Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells in vitro, we demonstrate that the expression of IL-32 isoforms is dependent on the time exposed to L. amazonensis and L. braziliensis antigens. Moreover, for the first time we show the functional consequences of three different genetic variations in the IL32 (rs4786370, rs4349147, rs1555001) modulating IL-32γ expression, influencing innate and adaptive cytokine production after Leishmania exposure. Using a Brazilian cohort of 107 American Tegumentary Leishmaniasis patients and a control cohort of 245 healthy individuals, the IL32 rs4786370 genetic variant was associated with protection against ATL, whereas the IL32 rs4349147 was associated with susceptibility to the development of localized cutaneous and mucosal leishmaniasis. These novel insights may help improve therapeutic strategies and lead to benefits for patients suffering from Leishmania infections. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 2 e0008029 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jéssica Cristina Dos Santos Valéria Bernadete Leite Quixabeira Muriel Vilela Teodoro Silva Michelle S M A Damen Kiki Schraa Martin Jaeger Marije Oosting Samuel T Keating Miriam Leandro Dorta Sebastião Alves Pinto Fernanda Bugalho Duarte Ledice Inácia de Araújo Pereira Mihai G Netea Fátima Ribeiro-Dias Leo A B Joosten Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells in vitro, we demonstrate that the expression of IL-32 isoforms is dependent on the time exposed to L. amazonensis and L. braziliensis antigens. Moreover, for the first time we show the functional consequences of three different genetic variations in the IL32 (rs4786370, rs4349147, rs1555001) modulating IL-32γ expression, influencing innate and adaptive cytokine production after Leishmania exposure. Using a Brazilian cohort of 107 American Tegumentary Leishmaniasis patients and a control cohort of 245 healthy individuals, the IL32 rs4786370 genetic variant was associated with protection against ATL, whereas the IL32 rs4349147 was associated with susceptibility to the development of localized cutaneous and mucosal leishmaniasis. These novel insights may help improve therapeutic strategies and lead to benefits for patients suffering from Leishmania infections. |
format |
Article in Journal/Newspaper |
author |
Jéssica Cristina Dos Santos Valéria Bernadete Leite Quixabeira Muriel Vilela Teodoro Silva Michelle S M A Damen Kiki Schraa Martin Jaeger Marije Oosting Samuel T Keating Miriam Leandro Dorta Sebastião Alves Pinto Fernanda Bugalho Duarte Ledice Inácia de Araújo Pereira Mihai G Netea Fátima Ribeiro-Dias Leo A B Joosten |
author_facet |
Jéssica Cristina Dos Santos Valéria Bernadete Leite Quixabeira Muriel Vilela Teodoro Silva Michelle S M A Damen Kiki Schraa Martin Jaeger Marije Oosting Samuel T Keating Miriam Leandro Dorta Sebastião Alves Pinto Fernanda Bugalho Duarte Ledice Inácia de Araújo Pereira Mihai G Netea Fátima Ribeiro-Dias Leo A B Joosten |
author_sort |
Jéssica Cristina Dos Santos |
title |
Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis. |
title_short |
Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis. |
title_full |
Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis. |
title_fullStr |
Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis. |
title_full_unstemmed |
Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis. |
title_sort |
genetic variation in interleukin-32 influence the immune response against new world leishmania species and susceptibility to american tegumentary leishmaniasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008029 https://doaj.org/article/4b4f16bfe8924b5c958c7729a0749dd7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0008029 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008029 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008029 https://doaj.org/article/4b4f16bfe8924b5c958c7729a0749dd7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008029 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
2 |
container_start_page |
e0008029 |
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1766337145960660992 |