Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings.
Dengue virus is endemic globally, throughout tropical and sub-tropical regions. While the number of epidemics due to the four DENV serotypes is pronounced in East Africa, the total number of cases reported in Africa (16 million infections) remained at low levels compared to Asia (70 million infectio...
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ftdoajarticles:oai:doaj.org/article:4b4739eea5a9454ca8897e1f9d0a65a6 2023-05-15T15:11:03+02:00 Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings. Erwan Le Gonidec Marianne Maquart Sandrine Duron Hélène Savini Geraldine Cazajous Pierre-Olivier Vidal Marie-Caroline Chenilleau Jean-Baptiste Roseau Alain Benois Céline Dehan Jeffrey Kugelman Isabelle Leparc-Goffart Serge Védy 2016-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004755 https://doaj.org/article/4b4739eea5a9454ca8897e1f9d0a65a6 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4920588?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004755 https://doaj.org/article/4b4739eea5a9454ca8897e1f9d0a65a6 PLoS Neglected Tropical Diseases, Vol 10, Iss 6, p e0004755 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004755 2022-12-31T09:17:47Z Dengue virus is endemic globally, throughout tropical and sub-tropical regions. While the number of epidemics due to the four DENV serotypes is pronounced in East Africa, the total number of cases reported in Africa (16 million infections) remained at low levels compared to Asia (70 million infections). The French Armed forces Health Service provides epidemiological surveillance support in the Republic of Djibouti through the Bouffard Military hospital. Between 2011 and 2014, clinical and biological data of suspected dengue syndromes were collected at the Bouffard Military hospital and analyzed to improve Dengue clinical diagnosis and evaluate its circulation in East Africa. Examining samples from patients that presented one or more Dengue-like symptoms the study evidenced 128 Dengue cases among 354 suspected cases (36.2% of the non-malarial Dengue-like syndromes). It also demonstrated the circulation of serotypes 1 and 2 and reports the first epidemic of serotype 3 infections in Djibouti which was found in all of the hospitalized patients in this study. Based on these results we have determined that screening for Malaria and the presence of the arthralgia, gastro-intestinal symptoms and lymphopenia < 1,000cell/ mm3 allows for negative predictive value and specificity of diagnosis in isolated areas superior to 80% up to day 6. This study also provides evidence for an epidemic of Dengue virus serotype 3 previously not detected in Djibouti. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 6 e0004755 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Erwan Le Gonidec Marianne Maquart Sandrine Duron Hélène Savini Geraldine Cazajous Pierre-Olivier Vidal Marie-Caroline Chenilleau Jean-Baptiste Roseau Alain Benois Céline Dehan Jeffrey Kugelman Isabelle Leparc-Goffart Serge Védy Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue virus is endemic globally, throughout tropical and sub-tropical regions. While the number of epidemics due to the four DENV serotypes is pronounced in East Africa, the total number of cases reported in Africa (16 million infections) remained at low levels compared to Asia (70 million infections). The French Armed forces Health Service provides epidemiological surveillance support in the Republic of Djibouti through the Bouffard Military hospital. Between 2011 and 2014, clinical and biological data of suspected dengue syndromes were collected at the Bouffard Military hospital and analyzed to improve Dengue clinical diagnosis and evaluate its circulation in East Africa. Examining samples from patients that presented one or more Dengue-like symptoms the study evidenced 128 Dengue cases among 354 suspected cases (36.2% of the non-malarial Dengue-like syndromes). It also demonstrated the circulation of serotypes 1 and 2 and reports the first epidemic of serotype 3 infections in Djibouti which was found in all of the hospitalized patients in this study. Based on these results we have determined that screening for Malaria and the presence of the arthralgia, gastro-intestinal symptoms and lymphopenia < 1,000cell/ mm3 allows for negative predictive value and specificity of diagnosis in isolated areas superior to 80% up to day 6. This study also provides evidence for an epidemic of Dengue virus serotype 3 previously not detected in Djibouti. |
format |
Article in Journal/Newspaper |
author |
Erwan Le Gonidec Marianne Maquart Sandrine Duron Hélène Savini Geraldine Cazajous Pierre-Olivier Vidal Marie-Caroline Chenilleau Jean-Baptiste Roseau Alain Benois Céline Dehan Jeffrey Kugelman Isabelle Leparc-Goffart Serge Védy |
author_facet |
Erwan Le Gonidec Marianne Maquart Sandrine Duron Hélène Savini Geraldine Cazajous Pierre-Olivier Vidal Marie-Caroline Chenilleau Jean-Baptiste Roseau Alain Benois Céline Dehan Jeffrey Kugelman Isabelle Leparc-Goffart Serge Védy |
author_sort |
Erwan Le Gonidec |
title |
Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings. |
title_short |
Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings. |
title_full |
Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings. |
title_fullStr |
Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings. |
title_full_unstemmed |
Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings. |
title_sort |
clinical survey of dengue virus circulation in the republic of djibouti between 2011 and 2014 identifies serotype 3 epidemic and recommends clinical diagnosis guidelines for resource limited settings. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004755 https://doaj.org/article/4b4739eea5a9454ca8897e1f9d0a65a6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 6, p e0004755 (2016) |
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http://europepmc.org/articles/PMC4920588?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004755 https://doaj.org/article/4b4739eea5a9454ca8897e1f9d0a65a6 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004755 |
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PLOS Neglected Tropical Diseases |
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