Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP).
Fur Animal Epidemic Necrotic Pyoderma (FENP) is a severe, often lethal infectious disease affecting all three fur animal species: mink (Neovision vision), foxes (Vulpes lagopus) and finnraccoons (Nyctereutes procyonoides). Previous studies showed an association between Arcanobacterium phocae and FEN...
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ftdoajarticles:oai:doaj.org/article:4aaf8a80efab4c99aae531a12f292f1f 2023-05-15T18:42:58+02:00 Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP). Heli Nordgren Kirsi Aaltonen Mirja Raunio-Saarnisto Antti Sukura Olli Vapalahti Tarja Sironen 2016-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0168129 https://doaj.org/article/4aaf8a80efab4c99aae531a12f292f1f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5156405?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0168129 https://doaj.org/article/4aaf8a80efab4c99aae531a12f292f1f PLoS ONE, Vol 11, Iss 12, p e0168129 (2016) Medicine R Science Q article 2016 ftdoajarticles https://doi.org/10.1371/journal.pone.0168129 2022-12-31T00:59:15Z Fur Animal Epidemic Necrotic Pyoderma (FENP) is a severe, often lethal infectious disease affecting all three fur animal species: mink (Neovision vision), foxes (Vulpes lagopus) and finnraccoons (Nyctereutes procyonoides). Previous studies showed an association between Arcanobacterium phocae and FENP. An experimental infection was conducted to confirm the ability of A. phocae to infect mink either alone or concurrently with a novel Streptococcus sp. found together with A. phocae in many cases of FENP. Different inoculation methods were tested to study possible routes of transmission. Typical signs, and gross- and histopathological findings for FENP were detected when naïve mink were infected with the tissue extract of mink with FENP, using a subcutaneous/ intradermal infection route. Edema, hemorrhage, necrosis and pus formation were detected in the infection site. A pure culture preparation of A. phocae alone or concurrently with the novel Streptococcus sp. caused severe acute signs of lethargy, apathy and anorexia and even mortality. The histopathological findings were similar to those found in naturally occurring cases of FENP. In contrast, the perorally infected mink presented no clinical signs nor any gross- or histopathological lesions. This study showed that A. phocae is able to cause FENP. The study also indicated that predisposing factors such as the environment, the general condition of the animals, temperature and skin trauma contribute to the development of the disease. Article in Journal/Newspaper Vulpes lagopus Directory of Open Access Journals: DOAJ Articles PLOS ONE 11 12 e0168129 |
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Medicine R Science Q Heli Nordgren Kirsi Aaltonen Mirja Raunio-Saarnisto Antti Sukura Olli Vapalahti Tarja Sironen Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP). |
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Medicine R Science Q |
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Fur Animal Epidemic Necrotic Pyoderma (FENP) is a severe, often lethal infectious disease affecting all three fur animal species: mink (Neovision vision), foxes (Vulpes lagopus) and finnraccoons (Nyctereutes procyonoides). Previous studies showed an association between Arcanobacterium phocae and FENP. An experimental infection was conducted to confirm the ability of A. phocae to infect mink either alone or concurrently with a novel Streptococcus sp. found together with A. phocae in many cases of FENP. Different inoculation methods were tested to study possible routes of transmission. Typical signs, and gross- and histopathological findings for FENP were detected when naïve mink were infected with the tissue extract of mink with FENP, using a subcutaneous/ intradermal infection route. Edema, hemorrhage, necrosis and pus formation were detected in the infection site. A pure culture preparation of A. phocae alone or concurrently with the novel Streptococcus sp. caused severe acute signs of lethargy, apathy and anorexia and even mortality. The histopathological findings were similar to those found in naturally occurring cases of FENP. In contrast, the perorally infected mink presented no clinical signs nor any gross- or histopathological lesions. This study showed that A. phocae is able to cause FENP. The study also indicated that predisposing factors such as the environment, the general condition of the animals, temperature and skin trauma contribute to the development of the disease. |
format |
Article in Journal/Newspaper |
author |
Heli Nordgren Kirsi Aaltonen Mirja Raunio-Saarnisto Antti Sukura Olli Vapalahti Tarja Sironen |
author_facet |
Heli Nordgren Kirsi Aaltonen Mirja Raunio-Saarnisto Antti Sukura Olli Vapalahti Tarja Sironen |
author_sort |
Heli Nordgren |
title |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP). |
title_short |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP). |
title_full |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP). |
title_fullStr |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP). |
title_full_unstemmed |
Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP). |
title_sort |
experimental infection of mink enforces the role of arcanobacterium phocae as causative agent of fur animal epidemic necrotic pyoderma (fenp). |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pone.0168129 https://doaj.org/article/4aaf8a80efab4c99aae531a12f292f1f |
genre |
Vulpes lagopus |
genre_facet |
Vulpes lagopus |
op_source |
PLoS ONE, Vol 11, Iss 12, p e0168129 (2016) |
op_relation |
http://europepmc.org/articles/PMC5156405?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0168129 https://doaj.org/article/4aaf8a80efab4c99aae531a12f292f1f |
op_doi |
https://doi.org/10.1371/journal.pone.0168129 |
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PLOS ONE |
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11 |
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12 |
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e0168129 |
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