Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic Impacto de la vacuna conjugada contra Haemophilus influenzae tipo b sobre la meningitis bacteriana en la República Dominicana
OBJECTIVES: Widespread use of Haemophilus influenzae type b (Hib) vaccines has dramatically reduced the burden of Hib disease throughout the Americas. Few studies have evaluated the impact of Hib vaccination on non-culture-confirmed disease. This study analyzed trends in probable bacterial meningiti...
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Pan American Health Organization
2008
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ftdoajarticles:oai:doaj.org/article:4a50d3f7fee94342b40b83052ee5c0e6 2023-05-15T15:17:43+02:00 Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic Impacto de la vacuna conjugada contra Haemophilus influenzae tipo b sobre la meningitis bacteriana en la República Dominicana Ellen H. Lee Miriam Corcino Arelis Moore Zacarias Garib Chabela Peña Jacqueline Sánchez Josefina Fernández Jesús M. Feris-Iglesias Brendan Flannery 2008-09-01T00:00:00Z https://doaj.org/article/4a50d3f7fee94342b40b83052ee5c0e6 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892008000900002 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/4a50d3f7fee94342b40b83052ee5c0e6 Revista Panamericana de Salud Pública, Vol 24, Iss 3, Pp 161-168 (2008) Haemophilus influenzae type b vacunas contra Haemophilus meningitis bacteriana inmunización República Dominicana Haemophilus influenzae type b conjugate vaccine bacterial meningitis immunization Dominican Republic Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles 2022-12-30T21:54:19Z OBJECTIVES: Widespread use of Haemophilus influenzae type b (Hib) vaccines has dramatically reduced the burden of Hib disease throughout the Americas. Few studies have evaluated the impact of Hib vaccination on non-culture-confirmed disease. This study analyzed trends in probable bacterial meningitis before and after the introduction of Hib vaccine in the Dominican Republic and estimated vaccine effectiveness against Hib meningitis. METHODS: Meningitis cases among children < 5 years of age were identified from admission records of the main pediatric hospital in Santo Domingo during 1998-2004. Laboratory criteria were used to classify meningitis cases with probable bacterial etiology; confirmed cases had positive bacterial culture or antigen detection in cerebrospinal fluid. Cumulative incidence rates of confirmed and probable bacterial meningitis were calculated for children living in the National District. Confirmed cases of Hib meningitis were enrolled in a case-control study with age- and neighborhood-matched control children to calculate vaccine effectiveness. RESULTS: Before vaccine introduction, annual rates of meningitis with probable bacterial etiology were 49 cases per 100 000 children < 5 years old; Hib accounted for 60% of confirmed bacterial cases. During 2002-2004, after vaccine introduction, annual rates of probable bacterial meningitis were 65% lower at 16 cases per 100 000, and Hib accounted for 26% of confirmed cases. Rates of Hib meningitis and probable bacterial meningitis with no determined etiology declined by 13 and 17 cases per 100 000, respectively. CONCLUSIONS: Introduction of Hib vaccine substantially reduced the incidence of confirmed and probable bacterial meningitis in the Dominican Republic. The estimated impact of Hib vaccination was twice as great when non-culture-confirmed disease was included. OBJETIVOS: El uso generalizado de la vacuna contra Haemophilus influenzae tipo b (Hib) ha permitido reducir radicalmente la carga de enfermedad por Hib en las Américas. Pocos ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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English Spanish Portuguese |
topic |
Haemophilus influenzae type b vacunas contra Haemophilus meningitis bacteriana inmunización República Dominicana Haemophilus influenzae type b conjugate vaccine bacterial meningitis immunization Dominican Republic Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Haemophilus influenzae type b vacunas contra Haemophilus meningitis bacteriana inmunización República Dominicana Haemophilus influenzae type b conjugate vaccine bacterial meningitis immunization Dominican Republic Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ellen H. Lee Miriam Corcino Arelis Moore Zacarias Garib Chabela Peña Jacqueline Sánchez Josefina Fernández Jesús M. Feris-Iglesias Brendan Flannery Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic Impacto de la vacuna conjugada contra Haemophilus influenzae tipo b sobre la meningitis bacteriana en la República Dominicana |
topic_facet |
Haemophilus influenzae type b vacunas contra Haemophilus meningitis bacteriana inmunización República Dominicana Haemophilus influenzae type b conjugate vaccine bacterial meningitis immunization Dominican Republic Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVES: Widespread use of Haemophilus influenzae type b (Hib) vaccines has dramatically reduced the burden of Hib disease throughout the Americas. Few studies have evaluated the impact of Hib vaccination on non-culture-confirmed disease. This study analyzed trends in probable bacterial meningitis before and after the introduction of Hib vaccine in the Dominican Republic and estimated vaccine effectiveness against Hib meningitis. METHODS: Meningitis cases among children < 5 years of age were identified from admission records of the main pediatric hospital in Santo Domingo during 1998-2004. Laboratory criteria were used to classify meningitis cases with probable bacterial etiology; confirmed cases had positive bacterial culture or antigen detection in cerebrospinal fluid. Cumulative incidence rates of confirmed and probable bacterial meningitis were calculated for children living in the National District. Confirmed cases of Hib meningitis were enrolled in a case-control study with age- and neighborhood-matched control children to calculate vaccine effectiveness. RESULTS: Before vaccine introduction, annual rates of meningitis with probable bacterial etiology were 49 cases per 100 000 children < 5 years old; Hib accounted for 60% of confirmed bacterial cases. During 2002-2004, after vaccine introduction, annual rates of probable bacterial meningitis were 65% lower at 16 cases per 100 000, and Hib accounted for 26% of confirmed cases. Rates of Hib meningitis and probable bacterial meningitis with no determined etiology declined by 13 and 17 cases per 100 000, respectively. CONCLUSIONS: Introduction of Hib vaccine substantially reduced the incidence of confirmed and probable bacterial meningitis in the Dominican Republic. The estimated impact of Hib vaccination was twice as great when non-culture-confirmed disease was included. OBJETIVOS: El uso generalizado de la vacuna contra Haemophilus influenzae tipo b (Hib) ha permitido reducir radicalmente la carga de enfermedad por Hib en las Américas. Pocos ... |
format |
Article in Journal/Newspaper |
author |
Ellen H. Lee Miriam Corcino Arelis Moore Zacarias Garib Chabela Peña Jacqueline Sánchez Josefina Fernández Jesús M. Feris-Iglesias Brendan Flannery |
author_facet |
Ellen H. Lee Miriam Corcino Arelis Moore Zacarias Garib Chabela Peña Jacqueline Sánchez Josefina Fernández Jesús M. Feris-Iglesias Brendan Flannery |
author_sort |
Ellen H. Lee |
title |
Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic Impacto de la vacuna conjugada contra Haemophilus influenzae tipo b sobre la meningitis bacteriana en la República Dominicana |
title_short |
Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic Impacto de la vacuna conjugada contra Haemophilus influenzae tipo b sobre la meningitis bacteriana en la República Dominicana |
title_full |
Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic Impacto de la vacuna conjugada contra Haemophilus influenzae tipo b sobre la meningitis bacteriana en la República Dominicana |
title_fullStr |
Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic Impacto de la vacuna conjugada contra Haemophilus influenzae tipo b sobre la meningitis bacteriana en la República Dominicana |
title_full_unstemmed |
Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic Impacto de la vacuna conjugada contra Haemophilus influenzae tipo b sobre la meningitis bacteriana en la República Dominicana |
title_sort |
impact of haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the dominican republic impacto de la vacuna conjugada contra haemophilus influenzae tipo b sobre la meningitis bacteriana en la república dominicana |
publisher |
Pan American Health Organization |
publishDate |
2008 |
url |
https://doaj.org/article/4a50d3f7fee94342b40b83052ee5c0e6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 24, Iss 3, Pp 161-168 (2008) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892008000900002 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/4a50d3f7fee94342b40b83052ee5c0e6 |
_version_ |
1766347955944554496 |