In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli
Background : Snakebites are considered a neglected tropical disease that affects thousands of people worldwide. Although antivenom is the only treatment available, it is associated with several side effects. As an alternative, plants have been extensively studied in order to obtain an alternative tr...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1186/1678-9199-20-12 https://doaj.org/article/4a420f92940b4ca79e51f0742bb232f5 |
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ftdoajarticles:oai:doaj.org/article:4a420f92940b4ca79e51f0742bb232f5 2023-05-15T15:05:34+02:00 In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli Bhavya Janardhan Vineetha M Shrikanth Kiran K Mirajkar Sunil S More 2014-05-01T00:00:00Z https://doi.org/10.1186/1678-9199-20-12 https://doaj.org/article/4a420f92940b4ca79e51f0742bb232f5 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200318&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/1678-9199-20-12 https://doaj.org/article/4a420f92940b4ca79e51f0742bb232f5 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 20, Iss 0 (2014) Acetylcholinesterase Azima tetracantha Antivenom Krait Viper In vitro Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2014 ftdoajarticles https://doi.org/10.1186/1678-9199-20-12 2022-12-31T06:01:51Z Background : Snakebites are considered a neglected tropical disease that affects thousands of people worldwide. Although antivenom is the only treatment available, it is associated with several side effects. As an alternative, plants have been extensively studied in order to obtain an alternative treatment. In folk medicine, Azima tetracanthaLam. is usually used to treat snakebites. The present study aims to provide a scientific explanation for the use of this plant against snakebite. The extracts of shade dried leaves of A. tetracanthawere tested for in vitroinhibitory activity on toxic venom enzymes like phosphomonoesterase, phosphodiesterase, acetylcholinesterase, hyaluronidase etc. from Bungarus caeruleusandVipera russellivenoms.Results : The ethylacetate extract rendered a significant inhibitory effect on the phosphomonoesterase, phosphodiesterase, phospholipase A2 and acetylcholinesterase enzymes.Conclusions : The present study suggests that ethylacetate extract of A. tetracanthaleaves possesses compounds that inhibit the activity of toxic enzymes from Bungarus caeruleusandVipera russellivenom. Further pharmacological andin vivostudies would provide evidence that this substance may lead to a potential treatment against these venoms. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 20 1 12 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Acetylcholinesterase Azima tetracantha Antivenom Krait Viper In vitro Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Acetylcholinesterase Azima tetracantha Antivenom Krait Viper In vitro Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Bhavya Janardhan Vineetha M Shrikanth Kiran K Mirajkar Sunil S More In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli |
topic_facet |
Acetylcholinesterase Azima tetracantha Antivenom Krait Viper In vitro Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Background : Snakebites are considered a neglected tropical disease that affects thousands of people worldwide. Although antivenom is the only treatment available, it is associated with several side effects. As an alternative, plants have been extensively studied in order to obtain an alternative treatment. In folk medicine, Azima tetracanthaLam. is usually used to treat snakebites. The present study aims to provide a scientific explanation for the use of this plant against snakebite. The extracts of shade dried leaves of A. tetracanthawere tested for in vitroinhibitory activity on toxic venom enzymes like phosphomonoesterase, phosphodiesterase, acetylcholinesterase, hyaluronidase etc. from Bungarus caeruleusandVipera russellivenoms.Results : The ethylacetate extract rendered a significant inhibitory effect on the phosphomonoesterase, phosphodiesterase, phospholipase A2 and acetylcholinesterase enzymes.Conclusions : The present study suggests that ethylacetate extract of A. tetracanthaleaves possesses compounds that inhibit the activity of toxic enzymes from Bungarus caeruleusandVipera russellivenom. Further pharmacological andin vivostudies would provide evidence that this substance may lead to a potential treatment against these venoms. |
format |
Article in Journal/Newspaper |
author |
Bhavya Janardhan Vineetha M Shrikanth Kiran K Mirajkar Sunil S More |
author_facet |
Bhavya Janardhan Vineetha M Shrikanth Kiran K Mirajkar Sunil S More |
author_sort |
Bhavya Janardhan |
title |
In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli |
title_short |
In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli |
title_full |
In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli |
title_fullStr |
In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli |
title_full_unstemmed |
In vitroscreening and evaluation of antivenom phytochemicals from Azima tetracanthaLam. leaves against Bungarus caeruleusand Vipera russelli |
title_sort |
in vitroscreening and evaluation of antivenom phytochemicals from azima tetracanthalam. leaves against bungarus caeruleusand vipera russelli |
publisher |
SciELO |
publishDate |
2014 |
url |
https://doi.org/10.1186/1678-9199-20-12 https://doaj.org/article/4a420f92940b4ca79e51f0742bb232f5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 20, Iss 0 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200318&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/1678-9199-20-12 https://doaj.org/article/4a420f92940b4ca79e51f0742bb232f5 |
op_doi |
https://doi.org/10.1186/1678-9199-20-12 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
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20 |
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1 |
container_start_page |
12 |
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1766337238660022272 |