Glycolysis and acute lung injury: A review

• Published in: Asian Pacific Journal of Tropical Medicine
• Main Authors: Yang Yi, Jun Chen, Nan Li, Yue Huang, Jichao Peng, Xiaoran Liu
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2023
• Subjects: acute lung injury; glycolysis; hypoxia-inducible factor 1; endothelium; macrophages; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.4103/1995-7645.388388; https://doaj.org/article/49e96e7808404786b2015aa3a615e25e

Acute lung injury is featured as diffuse pulmonary edema and persistent hypoxemia caused by lung or systemic injury. It is believed that these pathological changes are associated with damage to the alveolar epithelium and vascular endothelium, recruitment of inflammatory cells, and inflammatory factor storms. In recent years, the metabolic reprogramming of lung parenchymal cells and immune cells, particularly alterations in glycolysis, has been found to occur in acute lung injury. Inhibition of glycolysis can reduce the severity of acute lung injury. Thus, this review focuses on the interconnection between acute lung injury and glycolysis and the mechanisms of interaction, which may bring hope for the treatment of acute lung injury.