Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999–2016
Abstract Background Lymphatic filariasis (LF) is a mosquito-borne parasitic disease which is targeted for elimination as a public health problem worldwide. Niue is a small self-governing South Pacific island nation with approximately 1600 residents that was formerly LF endemic. Here, we review the p...
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ftdoajarticles:oai:doaj.org/article:49869da8ae274a4c9c27d3b26fd0be12 2023-05-15T15:14:47+02:00 Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999–2016 Catherine N. Carlingford Wayne Melrose Grizelda Mokoia Patricia M. Graves Kazuyo Ichimori Corinne Capuano Sung Hye Kim Padmasiri Aratchige Manila Nosa 2019-03-01T00:00:00Z https://doi.org/10.1186/s41182-019-0141-1 https://doaj.org/article/49869da8ae274a4c9c27d3b26fd0be12 EN eng BMC http://link.springer.com/article/10.1186/s41182-019-0141-1 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-019-0141-1 1349-4147 https://doaj.org/article/49869da8ae274a4c9c27d3b26fd0be12 Tropical Medicine and Health, Vol 47, Iss 1, Pp 1-10 (2019) Lymphatic filariasis Mass drug administration Niue Microfilaria Epidemiology Wuchereria bancrofti Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.1186/s41182-019-0141-1 2022-12-31T05:42:54Z Abstract Background Lymphatic filariasis (LF) is a mosquito-borne parasitic disease which is targeted for elimination as a public health problem worldwide. Niue is a small self-governing South Pacific island nation with approximately 1600 residents that was formerly LF endemic. Here, we review the progress made towards eliminating LF in Niue since 1999. Methods This study has reviewed all the available literature relating to LF in Niue to assess surveillance efforts and the elimination of transmission. Reviewed documentation included both published and unpublished works including historical reports of LF, WHO PacELF records, and Niue Country Reports of the national LF elimination program. Findings Niue conducted mapping of baseline LF endemicity by testing the total present and consenting population for LF antigen with immunochromatographic test (ICT) in 1999, when circulating filarial antigen prevalence was 3.1% (n = 1794). Five nationwide annual mass drug administration (MDA) rounds with albendazole (400 mg) and diethylcarbamazine citrate (DEC) were undertaken from 2000 to 2004, with coverage reported from distribution records ranging from 78 to 99% of the eligible population, which excluded pregnant women and children under 2 years of age. A further whole population survey using ICT in 2001 found 1.3% positive (n = 1630). In 2004, antigen prevalence had reduced to 0.2% (n = 1285). A similar post-MDA survey in 2009 indicated antigen prevalence to be 0.5% (n = 1378). Seven positive cases were re-tested and re-treated every six months until negative. Conclusions After five rounds of MDA, Niue had reduced the LF antigen population prevalence in all ages from 3.1% to below 1% and maintained this prevalence for a further five years. Due to Niue’s small population, surveillance was done by whole population surveys. Niue’s results support the WHO recommended strategy that five to six rounds of annual MDA with effective population coverage can successfully interrupt the transmission of LF. Niue received official ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific Tropical Medicine and Health 47 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Lymphatic filariasis Mass drug administration Niue Microfilaria Epidemiology Wuchereria bancrofti Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Lymphatic filariasis Mass drug administration Niue Microfilaria Epidemiology Wuchereria bancrofti Arctic medicine. Tropical medicine RC955-962 Catherine N. Carlingford Wayne Melrose Grizelda Mokoia Patricia M. Graves Kazuyo Ichimori Corinne Capuano Sung Hye Kim Padmasiri Aratchige Manila Nosa Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999–2016 |
topic_facet |
Lymphatic filariasis Mass drug administration Niue Microfilaria Epidemiology Wuchereria bancrofti Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Lymphatic filariasis (LF) is a mosquito-borne parasitic disease which is targeted for elimination as a public health problem worldwide. Niue is a small self-governing South Pacific island nation with approximately 1600 residents that was formerly LF endemic. Here, we review the progress made towards eliminating LF in Niue since 1999. Methods This study has reviewed all the available literature relating to LF in Niue to assess surveillance efforts and the elimination of transmission. Reviewed documentation included both published and unpublished works including historical reports of LF, WHO PacELF records, and Niue Country Reports of the national LF elimination program. Findings Niue conducted mapping of baseline LF endemicity by testing the total present and consenting population for LF antigen with immunochromatographic test (ICT) in 1999, when circulating filarial antigen prevalence was 3.1% (n = 1794). Five nationwide annual mass drug administration (MDA) rounds with albendazole (400 mg) and diethylcarbamazine citrate (DEC) were undertaken from 2000 to 2004, with coverage reported from distribution records ranging from 78 to 99% of the eligible population, which excluded pregnant women and children under 2 years of age. A further whole population survey using ICT in 2001 found 1.3% positive (n = 1630). In 2004, antigen prevalence had reduced to 0.2% (n = 1285). A similar post-MDA survey in 2009 indicated antigen prevalence to be 0.5% (n = 1378). Seven positive cases were re-tested and re-treated every six months until negative. Conclusions After five rounds of MDA, Niue had reduced the LF antigen population prevalence in all ages from 3.1% to below 1% and maintained this prevalence for a further five years. Due to Niue’s small population, surveillance was done by whole population surveys. Niue’s results support the WHO recommended strategy that five to six rounds of annual MDA with effective population coverage can successfully interrupt the transmission of LF. Niue received official ... |
format |
Article in Journal/Newspaper |
author |
Catherine N. Carlingford Wayne Melrose Grizelda Mokoia Patricia M. Graves Kazuyo Ichimori Corinne Capuano Sung Hye Kim Padmasiri Aratchige Manila Nosa |
author_facet |
Catherine N. Carlingford Wayne Melrose Grizelda Mokoia Patricia M. Graves Kazuyo Ichimori Corinne Capuano Sung Hye Kim Padmasiri Aratchige Manila Nosa |
author_sort |
Catherine N. Carlingford |
title |
Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999–2016 |
title_short |
Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999–2016 |
title_full |
Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999–2016 |
title_fullStr |
Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999–2016 |
title_full_unstemmed |
Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999–2016 |
title_sort |
elimination of lymphatic filariasis as a public health problem in niue under pacelf, 1999–2016 |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s41182-019-0141-1 https://doaj.org/article/49869da8ae274a4c9c27d3b26fd0be12 |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 47, Iss 1, Pp 1-10 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s41182-019-0141-1 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-019-0141-1 1349-4147 https://doaj.org/article/49869da8ae274a4c9c27d3b26fd0be12 |
op_doi |
https://doi.org/10.1186/s41182-019-0141-1 |
container_title |
Tropical Medicine and Health |
container_volume |
47 |
container_issue |
1 |
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1766345200631808000 |