Effects of isolation and confinement on gastrointestinal microbiota–a systematic review
PurposeThe gastrointestinal (GI) microbiota is a complex and dynamic ecosystem whose composition and function are influenced by many internal and external factors. Overall, the individual GI microbiota composition appears to be rather stable but can be influenced by extreme shifts in environmental e...
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ftdoajarticles:oai:doaj.org/article:4980252a0ae647e8b3b03fe084eafcf6 2023-07-30T03:59:28+02:00 Effects of isolation and confinement on gastrointestinal microbiota–a systematic review Bea Klos Christina Steinbach Jasmin Ketel Claude Lambert John Penders Joël Doré Paul Enck Isabelle Mack 2023-07-01T00:00:00Z https://doi.org/10.3389/fnut.2023.1214016 https://doaj.org/article/4980252a0ae647e8b3b03fe084eafcf6 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fnut.2023.1214016/full https://doaj.org/toc/2296-861X 2296-861X doi:10.3389/fnut.2023.1214016 https://doaj.org/article/4980252a0ae647e8b3b03fe084eafcf6 Frontiers in Nutrition, Vol 10 (2023) isolation confinement human microbiota gut gastrointestinal Nutrition. Foods and food supply TX341-641 article 2023 ftdoajarticles https://doi.org/10.3389/fnut.2023.1214016 2023-07-16T00:37:57Z PurposeThe gastrointestinal (GI) microbiota is a complex and dynamic ecosystem whose composition and function are influenced by many internal and external factors. Overall, the individual GI microbiota composition appears to be rather stable but can be influenced by extreme shifts in environmental exposures. To date, there is no systematic literature review that examines the effects of extreme environmental conditions, such as strict isolation and confinement, on the GI microbiota.MethodsWe conducted a systematic review to examine the effects of isolated and confined environments on the human GI microbiota. The literature search was conducted according to PRISMA criteria using PubMed, Web of Science and Cochrane Library. Relevant studies were identified based on exposure to isolated and confined environments, generally being also antigen-limited, for a minimum of 28 days and classified according to the microbiota analysis method (cultivation- or molecular based approaches) and the isolation habitat (space, space- or microgravity simulation such as MARS-500 or natural isolation such as Antarctica). Microbial shifts in abundance, alpha diversity and community structure in response to isolation were assessed.ResultsRegardless of the study habitat, inconsistent shifts in abundance of 40 different genera, mainly in the phylum Bacillota (formerly Firmicutes) were reported. Overall, the heterogeneity of studies was high. Reducing heterogeneity was neither possible by differentiating the microbiota analysis methods nor by subgrouping according to the isolation habitat. Alpha diversity evolved non-specifically, whereas the microbial community structure remained dissimilar despite partial convergence. The GI ecosystem returned to baseline levels following exposure, showing resilience irrespective of the experiment length.ConclusionAn isolated and confined environment has a considerable impact on the GI microbiota composition in terms of diversity and relative abundances of dominant taxa. However, due to a limited number ... Article in Journal/Newspaper Antarc* Antarctica Directory of Open Access Journals: DOAJ Articles Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) Frontiers in Nutrition 10 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
isolation confinement human microbiota gut gastrointestinal Nutrition. Foods and food supply TX341-641 |
spellingShingle |
isolation confinement human microbiota gut gastrointestinal Nutrition. Foods and food supply TX341-641 Bea Klos Christina Steinbach Jasmin Ketel Claude Lambert John Penders Joël Doré Paul Enck Isabelle Mack Effects of isolation and confinement on gastrointestinal microbiota–a systematic review |
topic_facet |
isolation confinement human microbiota gut gastrointestinal Nutrition. Foods and food supply TX341-641 |
description |
PurposeThe gastrointestinal (GI) microbiota is a complex and dynamic ecosystem whose composition and function are influenced by many internal and external factors. Overall, the individual GI microbiota composition appears to be rather stable but can be influenced by extreme shifts in environmental exposures. To date, there is no systematic literature review that examines the effects of extreme environmental conditions, such as strict isolation and confinement, on the GI microbiota.MethodsWe conducted a systematic review to examine the effects of isolated and confined environments on the human GI microbiota. The literature search was conducted according to PRISMA criteria using PubMed, Web of Science and Cochrane Library. Relevant studies were identified based on exposure to isolated and confined environments, generally being also antigen-limited, for a minimum of 28 days and classified according to the microbiota analysis method (cultivation- or molecular based approaches) and the isolation habitat (space, space- or microgravity simulation such as MARS-500 or natural isolation such as Antarctica). Microbial shifts in abundance, alpha diversity and community structure in response to isolation were assessed.ResultsRegardless of the study habitat, inconsistent shifts in abundance of 40 different genera, mainly in the phylum Bacillota (formerly Firmicutes) were reported. Overall, the heterogeneity of studies was high. Reducing heterogeneity was neither possible by differentiating the microbiota analysis methods nor by subgrouping according to the isolation habitat. Alpha diversity evolved non-specifically, whereas the microbial community structure remained dissimilar despite partial convergence. The GI ecosystem returned to baseline levels following exposure, showing resilience irrespective of the experiment length.ConclusionAn isolated and confined environment has a considerable impact on the GI microbiota composition in terms of diversity and relative abundances of dominant taxa. However, due to a limited number ... |
format |
Article in Journal/Newspaper |
author |
Bea Klos Christina Steinbach Jasmin Ketel Claude Lambert John Penders Joël Doré Paul Enck Isabelle Mack |
author_facet |
Bea Klos Christina Steinbach Jasmin Ketel Claude Lambert John Penders Joël Doré Paul Enck Isabelle Mack |
author_sort |
Bea Klos |
title |
Effects of isolation and confinement on gastrointestinal microbiota–a systematic review |
title_short |
Effects of isolation and confinement on gastrointestinal microbiota–a systematic review |
title_full |
Effects of isolation and confinement on gastrointestinal microbiota–a systematic review |
title_fullStr |
Effects of isolation and confinement on gastrointestinal microbiota–a systematic review |
title_full_unstemmed |
Effects of isolation and confinement on gastrointestinal microbiota–a systematic review |
title_sort |
effects of isolation and confinement on gastrointestinal microbiota–a systematic review |
publisher |
Frontiers Media S.A. |
publishDate |
2023 |
url |
https://doi.org/10.3389/fnut.2023.1214016 https://doaj.org/article/4980252a0ae647e8b3b03fe084eafcf6 |
long_lat |
ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Prisma |
geographic_facet |
Prisma |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Frontiers in Nutrition, Vol 10 (2023) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fnut.2023.1214016/full https://doaj.org/toc/2296-861X 2296-861X doi:10.3389/fnut.2023.1214016 https://doaj.org/article/4980252a0ae647e8b3b03fe084eafcf6 |
op_doi |
https://doi.org/10.3389/fnut.2023.1214016 |
container_title |
Frontiers in Nutrition |
container_volume |
10 |
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1772810310252494848 |