Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease?
Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in t...
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ftdoajarticles:oai:doaj.org/article:4974316a76f54b2e908fc58e1d3491a1 2023-05-15T15:13:49+02:00 Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease? Alexandre Andrade dos Anjos Jácome Enaldo Melo de Lima Ana Izabela Kazzi Gabriela Freitas Chaves Diego Cavalheiro de Mendonça Marina Mara Maciel José Sebastião dos Santos 2016-04-01T00:00:00Z https://doi.org/10.1590/0037-8682-0270-2015 https://doaj.org/article/4974316a76f54b2e908fc58e1d3491a1 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000200150&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0270-2015 https://doaj.org/article/4974316a76f54b2e908fc58e1d3491a1 Revista da Sociedade Brasileira de Medicina Tropical, Vol 49, Iss 2, Pp 150-157 (2016) Stomach neoplasms Epstein-Barr virus infections Genomics Epigenomics Molecular targeted therapy Arctic medicine. Tropical medicine RC955-962 article 2016 ftdoajarticles https://doi.org/10.1590/0037-8682-0270-2015 2022-12-31T03:06:24Z Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their malignant cells. Given that gastric cancer is the third leading cause of cancer-related mortality worldwide, with a global annual incidence of over 950,000 cases, EBV-positive gastric cancer is the largest group of EBV-associated malignancies. Based on gene expression profile studies, gastric cancer was recently categorized into four subtypes; EBV-positive, microsatellite unstable, genomically stable and chromosomal instability. Together with previous studies, this report provided a more detailed molecular characterization of gastric cancer, demonstrating that EBV-positive gastric cancer is a distinct molecular subtype of the disease, with unique genetic and epigenetic abnormalities, reflected in a specific phenotype. The recognition of characteristic molecular alterations in gastric cancer allows the identification of molecular pathways involved in cell proliferation and survival, with the potential to identify therapeutic targets. These findings highlight the enormous heterogeneity of gastric cancer, and the complex interplay between genetic and epigenetic alterations in the disease, and provide a roadmap to implementation of genome-guided personalized therapy in gastric cancer. The present review discusses the initial studies describing EBV-positive gastric cancer as a distinct clinical entity, presents recently described genetic and epigenetic alterations, and considers potential therapeutic insights derived from the recognition of this new molecular subtype of gastric adenocarcinoma. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 49 2 150 157 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Stomach neoplasms Epstein-Barr virus infections Genomics Epigenomics Molecular targeted therapy Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Stomach neoplasms Epstein-Barr virus infections Genomics Epigenomics Molecular targeted therapy Arctic medicine. Tropical medicine RC955-962 Alexandre Andrade dos Anjos Jácome Enaldo Melo de Lima Ana Izabela Kazzi Gabriela Freitas Chaves Diego Cavalheiro de Mendonça Marina Mara Maciel José Sebastião dos Santos Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease? |
topic_facet |
Stomach neoplasms Epstein-Barr virus infections Genomics Epigenomics Molecular targeted therapy Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their malignant cells. Given that gastric cancer is the third leading cause of cancer-related mortality worldwide, with a global annual incidence of over 950,000 cases, EBV-positive gastric cancer is the largest group of EBV-associated malignancies. Based on gene expression profile studies, gastric cancer was recently categorized into four subtypes; EBV-positive, microsatellite unstable, genomically stable and chromosomal instability. Together with previous studies, this report provided a more detailed molecular characterization of gastric cancer, demonstrating that EBV-positive gastric cancer is a distinct molecular subtype of the disease, with unique genetic and epigenetic abnormalities, reflected in a specific phenotype. The recognition of characteristic molecular alterations in gastric cancer allows the identification of molecular pathways involved in cell proliferation and survival, with the potential to identify therapeutic targets. These findings highlight the enormous heterogeneity of gastric cancer, and the complex interplay between genetic and epigenetic alterations in the disease, and provide a roadmap to implementation of genome-guided personalized therapy in gastric cancer. The present review discusses the initial studies describing EBV-positive gastric cancer as a distinct clinical entity, presents recently described genetic and epigenetic alterations, and considers potential therapeutic insights derived from the recognition of this new molecular subtype of gastric adenocarcinoma. |
format |
Article in Journal/Newspaper |
author |
Alexandre Andrade dos Anjos Jácome Enaldo Melo de Lima Ana Izabela Kazzi Gabriela Freitas Chaves Diego Cavalheiro de Mendonça Marina Mara Maciel José Sebastião dos Santos |
author_facet |
Alexandre Andrade dos Anjos Jácome Enaldo Melo de Lima Ana Izabela Kazzi Gabriela Freitas Chaves Diego Cavalheiro de Mendonça Marina Mara Maciel José Sebastião dos Santos |
author_sort |
Alexandre Andrade dos Anjos Jácome |
title |
Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease? |
title_short |
Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease? |
title_full |
Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease? |
title_fullStr |
Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease? |
title_full_unstemmed |
Epstein-Barr virus-positive gastric cancer: a distinct molecular subtype of the disease? |
title_sort |
epstein-barr virus-positive gastric cancer: a distinct molecular subtype of the disease? |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2016 |
url |
https://doi.org/10.1590/0037-8682-0270-2015 https://doaj.org/article/4974316a76f54b2e908fc58e1d3491a1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 49, Iss 2, Pp 150-157 (2016) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000200150&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0270-2015 https://doaj.org/article/4974316a76f54b2e908fc58e1d3491a1 |
op_doi |
https://doi.org/10.1590/0037-8682-0270-2015 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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49 |
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2 |
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150 |
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157 |
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