Infectious disease morbidity and growth among young HIV-exposed uninfected children in Jamaica
ABSTRACT Objective There is a growing body of data that demonstrates increased infectious disease outcomes for HIV-exposed uninfected (HIV-EU) infants as compared to their HIV-unexposed (HU) counterparts. We hypothesized that these HIV-EU infants are at greater risk for infectious morbidity and mort...
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ftdoajarticles:oai:doaj.org/article:48c8a36a1b3b42079944155d764d8f07 2023-05-15T15:15:18+02:00 Infectious disease morbidity and growth among young HIV-exposed uninfected children in Jamaica Russell B. Pierre Toni-Anne Fulford Kaye Lewis Paulette Palmer Christine Walters Celia D.C. Christie https://doaj.org/article/48c8a36a1b3b42079944155d764d8f07 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892016001200401&lng=en&tlng=en https://doaj.org/toc/1680-5348 1680-5348 https://doaj.org/article/48c8a36a1b3b42079944155d764d8f07 Revista Panamericana de Salud Pública, Vol 40, Iss 6, Pp 401-409 HIV infant infection morbidity Jamaica Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article ftdoajarticles 2022-12-31T05:29:51Z ABSTRACT Objective There is a growing body of data that demonstrates increased infectious disease outcomes for HIV-exposed uninfected (HIV-EU) infants as compared to their HIV-unexposed (HU) counterparts. We hypothesized that these HIV-EU infants are at greater risk for infectious morbidity and mortality when compared to the general childhood population. We therefore aimed to characterize infections and growth outcomes among HIV-EU infants in Jamaica during their first two years of life. By identifying these outcomes, specific interventions could be implemented to mitigate this risk of morbidity and mortality. Methods HIV-EU infants born between 1 January 2004 and 31 December 2006 in Kingston, Jamaica, were enrolled and followed in multicenter health facilities, using standardized protocols. HIV status was determined by RNA/DNA polymerase chain reaction (PCR) and confirmatory HIV enzyme-linked immunoassay (ELISA). Data were collected on demographic and anthropometric characteristics, infectious morbidity and mortality, and hospitalizations. Outcomes (incidence of infections and hospitalizations; growth (z scores for weight)) were determined, using univariate analyses. Results Of 195 HIV-EU infants followed for 25.9 months (standard deviation, 10.9 months), 102 (52%) were male, 185 (95%) were non-breast-fed, 161 (83%) experienced at least one infection, and 58 (30%) were hospitalized at least once. Infectious disease incidence per 1 000 child-weeks included upper respiratory tract infection of 7.25 (95% confidence interval (CI): 5.92–8.90), otitis media of 4.12 (3.21–5.20), and acute gastroenteritis (AGE) of 1.92 (1.35–2.65). Hospitalization incidence per 1 000 child-weeks included lower respiratory tract infections (LRTIs) of 0.89 (0.53–1.40), sepsis of 0.48 (0.23–0.89), and AGE of 0.43 (0.20–0.81). These infection incidence rates among the HIV-EU infants were higher than those for published community controls. Among the HIV-EU infants, the low-birthweight ones and those born via cesarean section had ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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HIV infant infection morbidity Jamaica Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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HIV infant infection morbidity Jamaica Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Russell B. Pierre Toni-Anne Fulford Kaye Lewis Paulette Palmer Christine Walters Celia D.C. Christie Infectious disease morbidity and growth among young HIV-exposed uninfected children in Jamaica |
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HIV infant infection morbidity Jamaica Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
ABSTRACT Objective There is a growing body of data that demonstrates increased infectious disease outcomes for HIV-exposed uninfected (HIV-EU) infants as compared to their HIV-unexposed (HU) counterparts. We hypothesized that these HIV-EU infants are at greater risk for infectious morbidity and mortality when compared to the general childhood population. We therefore aimed to characterize infections and growth outcomes among HIV-EU infants in Jamaica during their first two years of life. By identifying these outcomes, specific interventions could be implemented to mitigate this risk of morbidity and mortality. Methods HIV-EU infants born between 1 January 2004 and 31 December 2006 in Kingston, Jamaica, were enrolled and followed in multicenter health facilities, using standardized protocols. HIV status was determined by RNA/DNA polymerase chain reaction (PCR) and confirmatory HIV enzyme-linked immunoassay (ELISA). Data were collected on demographic and anthropometric characteristics, infectious morbidity and mortality, and hospitalizations. Outcomes (incidence of infections and hospitalizations; growth (z scores for weight)) were determined, using univariate analyses. Results Of 195 HIV-EU infants followed for 25.9 months (standard deviation, 10.9 months), 102 (52%) were male, 185 (95%) were non-breast-fed, 161 (83%) experienced at least one infection, and 58 (30%) were hospitalized at least once. Infectious disease incidence per 1 000 child-weeks included upper respiratory tract infection of 7.25 (95% confidence interval (CI): 5.92–8.90), otitis media of 4.12 (3.21–5.20), and acute gastroenteritis (AGE) of 1.92 (1.35–2.65). Hospitalization incidence per 1 000 child-weeks included lower respiratory tract infections (LRTIs) of 0.89 (0.53–1.40), sepsis of 0.48 (0.23–0.89), and AGE of 0.43 (0.20–0.81). These infection incidence rates among the HIV-EU infants were higher than those for published community controls. Among the HIV-EU infants, the low-birthweight ones and those born via cesarean section had ... |
format |
Article in Journal/Newspaper |
author |
Russell B. Pierre Toni-Anne Fulford Kaye Lewis Paulette Palmer Christine Walters Celia D.C. Christie |
author_facet |
Russell B. Pierre Toni-Anne Fulford Kaye Lewis Paulette Palmer Christine Walters Celia D.C. Christie |
author_sort |
Russell B. Pierre |
title |
Infectious disease morbidity and growth among young HIV-exposed uninfected children in Jamaica |
title_short |
Infectious disease morbidity and growth among young HIV-exposed uninfected children in Jamaica |
title_full |
Infectious disease morbidity and growth among young HIV-exposed uninfected children in Jamaica |
title_fullStr |
Infectious disease morbidity and growth among young HIV-exposed uninfected children in Jamaica |
title_full_unstemmed |
Infectious disease morbidity and growth among young HIV-exposed uninfected children in Jamaica |
title_sort |
infectious disease morbidity and growth among young hiv-exposed uninfected children in jamaica |
publisher |
Pan American Health Organization |
url |
https://doaj.org/article/48c8a36a1b3b42079944155d764d8f07 |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 40, Iss 6, Pp 401-409 |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892016001200401&lng=en&tlng=en https://doaj.org/toc/1680-5348 1680-5348 https://doaj.org/article/48c8a36a1b3b42079944155d764d8f07 |
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1766345665256882176 |