Studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients.
Royal jelly (RJ), a creamy substance secreted by honeybees, is the exclusive diet for queen bee differentiation and life maintenance. RJ has been used in cosmetics, beverages, medicines, and supplements worldwide. However, allergy is a concerning issue for RJ, especially in atopic dermatitis (AD) an...
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ftdoajarticles:oai:doaj.org/article:4851d8ab345a47a0b487a5d17269d29b 2023-05-15T18:20:07+02:00 Studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients. Taketoshi Hata Takako Furusawa-Horie Yasuko Arai Tomoko Takahashi Mariko Seishima Kenji Ichihara 2020-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0233707 https://doaj.org/article/4851d8ab345a47a0b487a5d17269d29b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pone.0233707 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0233707 https://doaj.org/article/4851d8ab345a47a0b487a5d17269d29b PLoS ONE, Vol 15, Iss 6, p e0233707 (2020) Medicine R Science Q article 2020 ftdoajarticles https://doi.org/10.1371/journal.pone.0233707 2022-12-31T10:34:41Z Royal jelly (RJ), a creamy substance secreted by honeybees, is the exclusive diet for queen bee differentiation and life maintenance. RJ has been used in cosmetics, beverages, medicines, and supplements worldwide. However, allergy is a concerning issue for RJ, especially in atopic dermatitis (AD) and asthma patients. In some cases, allergic reactions are seen after the first intake of RJ, suggesting the existence of allergens cross-reactive with RJ. Information about the cross-reactive allergens is very important for the safe application of RJ; however, study of this cross-reactivity is quite limited. In this study, we attempted to identify allergens cross-reactive with RJ by using serum samples from 30 AD patients who had never been exposed to RJ. In an enzyme-linked immunosorbent assay (ELISA) experiment, RJ-binding IgE antibodies were detected in the serum of 10 out of 30 patients, and their antibody titers ranged from 4- to 2,048-fold dilution ratios. Additionally, 3 AD patients were determined to be positive in a skin-prick test (SPT) with an RJ solution. Significant correlations were observed between the anti-RJ antibody titer and nonspecific IgE and between the anti-RJ antibody titer and the Eczema Area and Severity Index score. We further examined the cross-reactivity between RJ and 14 typical allergens by using an ELISA-inhibition assay and demonstrated that the following 6 allergens showed cross-reactivity with RJ: the European house dust mite (HDM) (Dermatophagoides pteronyssinus), American HDM (Dermatophagoides farinae), snow crab (Chionocetes spp.), edible crab (Cancer pagurus), German cockroach (Blatella germanica), and honeybee venom (Apis mellifera). In conclusion, people with a history of allergic diseases, including AD, asthma, and allergic rhinitis, should be cautioned against consuming RJ products because of the potential for cross-reactive responses to ensure the safe and successful use of RJ supplements. Article in Journal/Newspaper Snow crab Mite Directory of Open Access Journals: DOAJ Articles PLOS ONE 15 6 e0233707 |
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English |
topic |
Medicine R Science Q |
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Medicine R Science Q Taketoshi Hata Takako Furusawa-Horie Yasuko Arai Tomoko Takahashi Mariko Seishima Kenji Ichihara Studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients. |
topic_facet |
Medicine R Science Q |
description |
Royal jelly (RJ), a creamy substance secreted by honeybees, is the exclusive diet for queen bee differentiation and life maintenance. RJ has been used in cosmetics, beverages, medicines, and supplements worldwide. However, allergy is a concerning issue for RJ, especially in atopic dermatitis (AD) and asthma patients. In some cases, allergic reactions are seen after the first intake of RJ, suggesting the existence of allergens cross-reactive with RJ. Information about the cross-reactive allergens is very important for the safe application of RJ; however, study of this cross-reactivity is quite limited. In this study, we attempted to identify allergens cross-reactive with RJ by using serum samples from 30 AD patients who had never been exposed to RJ. In an enzyme-linked immunosorbent assay (ELISA) experiment, RJ-binding IgE antibodies were detected in the serum of 10 out of 30 patients, and their antibody titers ranged from 4- to 2,048-fold dilution ratios. Additionally, 3 AD patients were determined to be positive in a skin-prick test (SPT) with an RJ solution. Significant correlations were observed between the anti-RJ antibody titer and nonspecific IgE and between the anti-RJ antibody titer and the Eczema Area and Severity Index score. We further examined the cross-reactivity between RJ and 14 typical allergens by using an ELISA-inhibition assay and demonstrated that the following 6 allergens showed cross-reactivity with RJ: the European house dust mite (HDM) (Dermatophagoides pteronyssinus), American HDM (Dermatophagoides farinae), snow crab (Chionocetes spp.), edible crab (Cancer pagurus), German cockroach (Blatella germanica), and honeybee venom (Apis mellifera). In conclusion, people with a history of allergic diseases, including AD, asthma, and allergic rhinitis, should be cautioned against consuming RJ products because of the potential for cross-reactive responses to ensure the safe and successful use of RJ supplements. |
format |
Article in Journal/Newspaper |
author |
Taketoshi Hata Takako Furusawa-Horie Yasuko Arai Tomoko Takahashi Mariko Seishima Kenji Ichihara |
author_facet |
Taketoshi Hata Takako Furusawa-Horie Yasuko Arai Tomoko Takahashi Mariko Seishima Kenji Ichihara |
author_sort |
Taketoshi Hata |
title |
Studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients. |
title_short |
Studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients. |
title_full |
Studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients. |
title_fullStr |
Studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients. |
title_full_unstemmed |
Studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients. |
title_sort |
studies of royal jelly and associated cross-reactive allergens in atopic dermatitis patients. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pone.0233707 https://doaj.org/article/4851d8ab345a47a0b487a5d17269d29b |
genre |
Snow crab Mite |
genre_facet |
Snow crab Mite |
op_source |
PLoS ONE, Vol 15, Iss 6, p e0233707 (2020) |
op_relation |
https://doi.org/10.1371/journal.pone.0233707 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0233707 https://doaj.org/article/4851d8ab345a47a0b487a5d17269d29b |
op_doi |
https://doi.org/10.1371/journal.pone.0233707 |
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PLOS ONE |
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15 |
container_issue |
6 |
container_start_page |
e0233707 |
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