Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats
Objective: To evaluate the hepatocurative effects of aqueous root bark, stem bark and leaves of Vitex doniana in carbon tetrachloride (CCl4) induced liver damage and non induced liver damage albino rats. Methods: A total of 60 albino rats (36 induced liver damage and 24 non induced liver damage) wer...
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Wolters Kluwer Medknow Publications
2014
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Online Access: | https://doi.org/10.12980/APJTB.4.2014C207 https://doaj.org/article/484af3dc31194d5ca2c0e1c640f3d85f |
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ftdoajarticles:oai:doaj.org/article:484af3dc31194d5ca2c0e1c640f3d85f 2023-05-15T15:18:01+02:00 Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats James Dorcas Bolanle Kadejo Olubukola Adetoro Sallau Abdullahi Balarabe Owolabi Olumuyiwa Adeyemi 2014-06-01T00:00:00Z https://doi.org/10.12980/APJTB.4.2014C207 https://doaj.org/article/484af3dc31194d5ca2c0e1c640f3d85f EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115302264 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C207 https://doaj.org/article/484af3dc31194d5ca2c0e1c640f3d85f Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 6, Pp 480-485 (2014) Vitex doniana Hepatocurative Liver damage Creatinine Carbon tetrachloride Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.2014C207 2022-12-31T02:06:13Z Objective: To evaluate the hepatocurative effects of aqueous root bark, stem bark and leaves of Vitex doniana in carbon tetrachloride (CCl4) induced liver damage and non induced liver damage albino rats. Methods: A total of 60 albino rats (36 induced liver damage and 24 non induced liver damage) were assigned into liver damage and non liver damage groups of 6 rats in a group. The animals in the CCl4 induced liver damage groups, were induced by intraperitoneal injection with a single dose of CCl4 (1 mL/kg body weight) as a 1:1(v/v) solution in olive oil and were fasted for 36 h before the subsequent treatment with aqueous root bark, stem bark and leaves extracts of Vitex doniana and vitamin E as standard drug (100 mg/kg body weight per day) for 21 d, while the animals in the non induced groups were only treated with the daily oral administration of these extracts at the same dose. The administration of CCl4 was done once a week for a period of 3 weeks. Results: There was significant (P<0.05) increase in concentration of all liver marker enzymes, alanine aminotransferase, aspartate aminotransferase and alkaline aminotransferase (ALT, AST and ALP) and significant (P<0.05) decrease in albumin in the CCl4 induced liver damage control when compared to the normal control. The extracts caused a significant (P<0.05) reduction in the serum activities of liver marker enzymes (ALT, AST and ALP) and a significant (P<0.05) increase in albumin of all the induced treated groups. Only stem bark extract and vitamin E significantly (P<0.05) increased total protein. All the extracts significantly (P<0.05) lowered serum creatinine whereas only root bark extract significantly (P<0.05) lowered serum level of urea in the rats with CCl4 induced liver damage. Conclusion: Hepatocurative study shows that all the plant parts (root bark, stem bark and leaves) possess significant hepatocurative properties among other therapeutic values justifying their use in folklore medicine. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 6 480 485 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Vitex doniana Hepatocurative Liver damage Creatinine Carbon tetrachloride Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Vitex doniana Hepatocurative Liver damage Creatinine Carbon tetrachloride Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 James Dorcas Bolanle Kadejo Olubukola Adetoro Sallau Abdullahi Balarabe Owolabi Olumuyiwa Adeyemi Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats |
topic_facet |
Vitex doniana Hepatocurative Liver damage Creatinine Carbon tetrachloride Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the hepatocurative effects of aqueous root bark, stem bark and leaves of Vitex doniana in carbon tetrachloride (CCl4) induced liver damage and non induced liver damage albino rats. Methods: A total of 60 albino rats (36 induced liver damage and 24 non induced liver damage) were assigned into liver damage and non liver damage groups of 6 rats in a group. The animals in the CCl4 induced liver damage groups, were induced by intraperitoneal injection with a single dose of CCl4 (1 mL/kg body weight) as a 1:1(v/v) solution in olive oil and were fasted for 36 h before the subsequent treatment with aqueous root bark, stem bark and leaves extracts of Vitex doniana and vitamin E as standard drug (100 mg/kg body weight per day) for 21 d, while the animals in the non induced groups were only treated with the daily oral administration of these extracts at the same dose. The administration of CCl4 was done once a week for a period of 3 weeks. Results: There was significant (P<0.05) increase in concentration of all liver marker enzymes, alanine aminotransferase, aspartate aminotransferase and alkaline aminotransferase (ALT, AST and ALP) and significant (P<0.05) decrease in albumin in the CCl4 induced liver damage control when compared to the normal control. The extracts caused a significant (P<0.05) reduction in the serum activities of liver marker enzymes (ALT, AST and ALP) and a significant (P<0.05) increase in albumin of all the induced treated groups. Only stem bark extract and vitamin E significantly (P<0.05) increased total protein. All the extracts significantly (P<0.05) lowered serum creatinine whereas only root bark extract significantly (P<0.05) lowered serum level of urea in the rats with CCl4 induced liver damage. Conclusion: Hepatocurative study shows that all the plant parts (root bark, stem bark and leaves) possess significant hepatocurative properties among other therapeutic values justifying their use in folklore medicine. |
format |
Article in Journal/Newspaper |
author |
James Dorcas Bolanle Kadejo Olubukola Adetoro Sallau Abdullahi Balarabe Owolabi Olumuyiwa Adeyemi |
author_facet |
James Dorcas Bolanle Kadejo Olubukola Adetoro Sallau Abdullahi Balarabe Owolabi Olumuyiwa Adeyemi |
author_sort |
James Dorcas Bolanle |
title |
Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats |
title_short |
Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats |
title_full |
Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats |
title_fullStr |
Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats |
title_full_unstemmed |
Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats |
title_sort |
hepatocurative potential of vitex doniana root bark, stem bark and leaves extracts against ccl4–induced liver damage in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.2014C207 https://doaj.org/article/484af3dc31194d5ca2c0e1c640f3d85f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 6, Pp 480-485 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115302264 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C207 https://doaj.org/article/484af3dc31194d5ca2c0e1c640f3d85f |
op_doi |
https://doi.org/10.12980/APJTB.4.2014C207 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_issue |
6 |
container_start_page |
480 |
op_container_end_page |
485 |
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1766348252034105344 |