In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species
Introduction There are few studies reporting the antifungal activities of Lippia alba extracts. Methods A broth microdilution assay was used to evaluate the antifungal effects of Lippia alba extracts against seven yeast species of Candida and Cryptococcus. The butanol fraction was investigated by ga...
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ftdoajarticles:oai:doaj.org/article:4849d202aa344b499475b49565d24bde 2023-05-15T15:01:27+02:00 In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species Graziela Teixeira de Oliveira Jaqueline Maria Siqueira Ferreira Luiz Henrique Rosa Ezequias Pessoa de Siqueira Susana Johann Luciana Alves Rodrigues dos Santos Lima 2014-04-01T00:00:00Z https://doi.org/10.1590/0037-8682-0008-2013 https://doaj.org/article/4849d202aa344b499475b49565d24bde EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200247&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0008-2013 https://doaj.org/article/4849d202aa344b499475b49565d24bde Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 2, Pp 247-250 (2014) Lippia alba Antifungal activity Yeast Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.1590/0037-8682-0008-2013 2022-12-31T02:52:50Z Introduction There are few studies reporting the antifungal activities of Lippia alba extracts. Methods A broth microdilution assay was used to evaluate the antifungal effects of Lippia alba extracts against seven yeast species of Candida and Cryptococcus. The butanol fraction was investigated by gas chromatography-mass spectrometry. Results The butanol fraction showed the highest activity against Candida glabrata. The fraction also acted synergistically with itraconazole and fluconazole against C. glabrata. The dominant compounds in the butanol fraction were 2,2,5-trimethyl-3,4-hexanedione, 3,5-dimethyl-4-octanone and hexadecane. Conclusions The butanol fraction may be a good candidate in the search for new drugs from natural products with antifungal activity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 47 2 247 250 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Lippia alba Antifungal activity Yeast Arctic medicine. Tropical medicine RC955-962 |
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Lippia alba Antifungal activity Yeast Arctic medicine. Tropical medicine RC955-962 Graziela Teixeira de Oliveira Jaqueline Maria Siqueira Ferreira Luiz Henrique Rosa Ezequias Pessoa de Siqueira Susana Johann Luciana Alves Rodrigues dos Santos Lima In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species |
topic_facet |
Lippia alba Antifungal activity Yeast Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction There are few studies reporting the antifungal activities of Lippia alba extracts. Methods A broth microdilution assay was used to evaluate the antifungal effects of Lippia alba extracts against seven yeast species of Candida and Cryptococcus. The butanol fraction was investigated by gas chromatography-mass spectrometry. Results The butanol fraction showed the highest activity against Candida glabrata. The fraction also acted synergistically with itraconazole and fluconazole against C. glabrata. The dominant compounds in the butanol fraction were 2,2,5-trimethyl-3,4-hexanedione, 3,5-dimethyl-4-octanone and hexadecane. Conclusions The butanol fraction may be a good candidate in the search for new drugs from natural products with antifungal activity. |
format |
Article in Journal/Newspaper |
author |
Graziela Teixeira de Oliveira Jaqueline Maria Siqueira Ferreira Luiz Henrique Rosa Ezequias Pessoa de Siqueira Susana Johann Luciana Alves Rodrigues dos Santos Lima |
author_facet |
Graziela Teixeira de Oliveira Jaqueline Maria Siqueira Ferreira Luiz Henrique Rosa Ezequias Pessoa de Siqueira Susana Johann Luciana Alves Rodrigues dos Santos Lima |
author_sort |
Graziela Teixeira de Oliveira |
title |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species |
title_short |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species |
title_full |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species |
title_fullStr |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species |
title_full_unstemmed |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species |
title_sort |
in vitro antifungal activities of leaf extracts of lippia alba (verbenaceae) against clinically important yeast species |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2014 |
url |
https://doi.org/10.1590/0037-8682-0008-2013 https://doaj.org/article/4849d202aa344b499475b49565d24bde |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 2, Pp 247-250 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200247&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0008-2013 https://doaj.org/article/4849d202aa344b499475b49565d24bde |
op_doi |
https://doi.org/10.1590/0037-8682-0008-2013 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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47 |
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2 |
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247 |
op_container_end_page |
250 |
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