Factors influencing phagocytosis of malaria parasites: the story so far

Abstract There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to fight infection and one of these immune functions is phagocytosis. Effective and timely phagocytosis of parasites, accompanied by the activation...

Full description

Bibliographic Details
Published in:Malaria Journal
Main Authors: Caroline Lin Lin Chua, Ida May Jen Ng, Bryan Ju Min Yap, Andrew Teo
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2021
Subjects:
Online Access:https://doi.org/10.1186/s12936-021-03849-1
https://doaj.org/article/484786679495451f8ad037070bb3e9ae
id ftdoajarticles:oai:doaj.org/article:484786679495451f8ad037070bb3e9ae
record_format openpolar
spelling ftdoajarticles:oai:doaj.org/article:484786679495451f8ad037070bb3e9ae 2023-05-15T15:06:06+02:00 Factors influencing phagocytosis of malaria parasites: the story so far Caroline Lin Lin Chua Ida May Jen Ng Bryan Ju Min Yap Andrew Teo 2021-07-01T00:00:00Z https://doi.org/10.1186/s12936-021-03849-1 https://doaj.org/article/484786679495451f8ad037070bb3e9ae EN eng BMC https://doi.org/10.1186/s12936-021-03849-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03849-1 1475-2875 https://doaj.org/article/484786679495451f8ad037070bb3e9ae Malaria Journal, Vol 20, Iss 1, Pp 1-15 (2021) Phagocytosis Opsonic Non-opsonic Monocytes Macrophages Neutrophils Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03849-1 2022-12-31T09:36:06Z Abstract There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to fight infection and one of these immune functions is phagocytosis. Effective and timely phagocytosis of parasites, accompanied by the activation of a regulated inflammatory response, is beneficial for parasite clearance. Functional studies have identified specific opsonins, particularly antibodies and distinct phagocyte sub-populations that are associated with clinical protection against malaria. In addition, cellular and molecular studies have enhanced the understanding of the immunological pathways and outcomes following phagocytosis of malaria parasites. In this review, an integrated view of the factors that can affect phagocytosis of infected erythrocytes and parasite components, the immunological consequences and their association with clinical protection against Plasmodium spp. infection is provided. Several red blood cell disorders and co-infections, and drugs that can influence phagocytic capability during malaria are also discussed. It is hoped that an enhanced understanding of this immunological process can benefit the design of new therapeutics and vaccines to combat this infectious disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Phagocytosis
Opsonic
Non-opsonic
Monocytes
Macrophages
Neutrophils
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
spellingShingle Phagocytosis
Opsonic
Non-opsonic
Monocytes
Macrophages
Neutrophils
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Caroline Lin Lin Chua
Ida May Jen Ng
Bryan Ju Min Yap
Andrew Teo
Factors influencing phagocytosis of malaria parasites: the story so far
topic_facet Phagocytosis
Opsonic
Non-opsonic
Monocytes
Macrophages
Neutrophils
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
description Abstract There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to fight infection and one of these immune functions is phagocytosis. Effective and timely phagocytosis of parasites, accompanied by the activation of a regulated inflammatory response, is beneficial for parasite clearance. Functional studies have identified specific opsonins, particularly antibodies and distinct phagocyte sub-populations that are associated with clinical protection against malaria. In addition, cellular and molecular studies have enhanced the understanding of the immunological pathways and outcomes following phagocytosis of malaria parasites. In this review, an integrated view of the factors that can affect phagocytosis of infected erythrocytes and parasite components, the immunological consequences and their association with clinical protection against Plasmodium spp. infection is provided. Several red blood cell disorders and co-infections, and drugs that can influence phagocytic capability during malaria are also discussed. It is hoped that an enhanced understanding of this immunological process can benefit the design of new therapeutics and vaccines to combat this infectious disease.
format Article in Journal/Newspaper
author Caroline Lin Lin Chua
Ida May Jen Ng
Bryan Ju Min Yap
Andrew Teo
author_facet Caroline Lin Lin Chua
Ida May Jen Ng
Bryan Ju Min Yap
Andrew Teo
author_sort Caroline Lin Lin Chua
title Factors influencing phagocytosis of malaria parasites: the story so far
title_short Factors influencing phagocytosis of malaria parasites: the story so far
title_full Factors influencing phagocytosis of malaria parasites: the story so far
title_fullStr Factors influencing phagocytosis of malaria parasites: the story so far
title_full_unstemmed Factors influencing phagocytosis of malaria parasites: the story so far
title_sort factors influencing phagocytosis of malaria parasites: the story so far
publisher BMC
publishDate 2021
url https://doi.org/10.1186/s12936-021-03849-1
https://doaj.org/article/484786679495451f8ad037070bb3e9ae
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source Malaria Journal, Vol 20, Iss 1, Pp 1-15 (2021)
op_relation https://doi.org/10.1186/s12936-021-03849-1
https://doaj.org/toc/1475-2875
doi:10.1186/s12936-021-03849-1
1475-2875
https://doaj.org/article/484786679495451f8ad037070bb3e9ae
op_doi https://doi.org/10.1186/s12936-021-03849-1
container_title Malaria Journal
container_volume 20
container_issue 1
_version_ 1766337765225529344