Genetic diversity and evolution of Hantaan virus in China and its neighbors.
Background Hantaan virus (HTNV; family Hantaviridae, order Bunyavirales) causes hemorrhagic fever with renal syndrome (HFRS), which has raised serious concerns in Eurasia, especially in China, Russia, and South Korea. Previous studies reported genetic diversity and phylogenetic features of HTNV in d...
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ftdoajarticles:oai:doaj.org/article:482f279f3b5a455295917d03d622d0ae 2023-05-15T15:08:31+02:00 Genetic diversity and evolution of Hantaan virus in China and its neighbors. Naizhe Li Aqian Li Yang Liu Wei Wu Chuan Li Dongyang Yu Yu Zhu Jiandong Li Dexin Li Shiwen Wang Mifang Liang 2020-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008090 https://doaj.org/article/482f279f3b5a455295917d03d622d0ae EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008090 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008090 https://doaj.org/article/482f279f3b5a455295917d03d622d0ae PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008090 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008090 2022-12-31T05:59:59Z Background Hantaan virus (HTNV; family Hantaviridae, order Bunyavirales) causes hemorrhagic fever with renal syndrome (HFRS), which has raised serious concerns in Eurasia, especially in China, Russia, and South Korea. Previous studies reported genetic diversity and phylogenetic features of HTNV in different parts of China, but the analyses from the holistic perspective are rare. Methodology and principal findings To better understand HTNV genetic diversity and gene evolution, we analyzed all available complete sequences derived from the small (S) and medium (M) segments with bioinformatic tools. Eleven phylogenetic groups were defined and showed geographic clustering; 42 significant amino acid variant sites were found, and 19 of them were located in immune epitopes; nine recombinant events and eight reassortments with highly divergent sequences were found and analyzed. We found that sequences from Guizhou showed high genetic divergence, contributing to multiple lineages of the phylogenetic tree and also to the recombination and reassortment events. Bayesian stochastic search variable selection analysis revealed that Heilongjiang, Shaanxi, and Guizhou played important roles in HTNV evolution and migration; the virus may originate from Zhejiang Province in the eastern part of China; and the virus population size expanded from the 1980s to 1990s. Conclusions/significance These findings revealed the original and evolutionary features of HTNV, which will help to illustrate hantavirus epidemic trends, thus aiding in disease control and prevention. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 8 e0008090 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Naizhe Li Aqian Li Yang Liu Wei Wu Chuan Li Dongyang Yu Yu Zhu Jiandong Li Dexin Li Shiwen Wang Mifang Liang Genetic diversity and evolution of Hantaan virus in China and its neighbors. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Hantaan virus (HTNV; family Hantaviridae, order Bunyavirales) causes hemorrhagic fever with renal syndrome (HFRS), which has raised serious concerns in Eurasia, especially in China, Russia, and South Korea. Previous studies reported genetic diversity and phylogenetic features of HTNV in different parts of China, but the analyses from the holistic perspective are rare. Methodology and principal findings To better understand HTNV genetic diversity and gene evolution, we analyzed all available complete sequences derived from the small (S) and medium (M) segments with bioinformatic tools. Eleven phylogenetic groups were defined and showed geographic clustering; 42 significant amino acid variant sites were found, and 19 of them were located in immune epitopes; nine recombinant events and eight reassortments with highly divergent sequences were found and analyzed. We found that sequences from Guizhou showed high genetic divergence, contributing to multiple lineages of the phylogenetic tree and also to the recombination and reassortment events. Bayesian stochastic search variable selection analysis revealed that Heilongjiang, Shaanxi, and Guizhou played important roles in HTNV evolution and migration; the virus may originate from Zhejiang Province in the eastern part of China; and the virus population size expanded from the 1980s to 1990s. Conclusions/significance These findings revealed the original and evolutionary features of HTNV, which will help to illustrate hantavirus epidemic trends, thus aiding in disease control and prevention. |
format |
Article in Journal/Newspaper |
author |
Naizhe Li Aqian Li Yang Liu Wei Wu Chuan Li Dongyang Yu Yu Zhu Jiandong Li Dexin Li Shiwen Wang Mifang Liang |
author_facet |
Naizhe Li Aqian Li Yang Liu Wei Wu Chuan Li Dongyang Yu Yu Zhu Jiandong Li Dexin Li Shiwen Wang Mifang Liang |
author_sort |
Naizhe Li |
title |
Genetic diversity and evolution of Hantaan virus in China and its neighbors. |
title_short |
Genetic diversity and evolution of Hantaan virus in China and its neighbors. |
title_full |
Genetic diversity and evolution of Hantaan virus in China and its neighbors. |
title_fullStr |
Genetic diversity and evolution of Hantaan virus in China and its neighbors. |
title_full_unstemmed |
Genetic diversity and evolution of Hantaan virus in China and its neighbors. |
title_sort |
genetic diversity and evolution of hantaan virus in china and its neighbors. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008090 https://doaj.org/article/482f279f3b5a455295917d03d622d0ae |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008090 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008090 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008090 https://doaj.org/article/482f279f3b5a455295917d03d622d0ae |
op_doi |
https://doi.org/10.1371/journal.pntd.0008090 |
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PLOS Neglected Tropical Diseases |
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14 |
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8 |
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e0008090 |
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