The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors
Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry ex...
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2008
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ftdoajarticles:oai:doaj.org/article:480da096a2944da9a7314b30e25ed816 2023-05-15T16:59:07+02:00 The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors Ileana Cornelia Farcasanu Valentina Negoita Ion Gruia Eliza Oprea Maria Iuliana Gruia 2008-03-01T00:00:00Z https://doi.org/10.3390/molecules13051195 https://doaj.org/article/480da096a2944da9a7314b30e25ed816 EN eng MDPI AG http://www.mdpi.com/1420-3049/13/5/1195/ https://doaj.org/toc/1420-3049 doi:10.3390/molecules13051195 1420-3049 https://doaj.org/article/480da096a2944da9a7314b30e25ed816 Molecules, Vol 13, Iss 5, Pp 1195-1206 (2008) Antioxidant Lonicera caerulaea experimental tumors lipid peroxidation ceruloplasmin thiol groups Organic chemistry QD241-441 article 2008 ftdoajarticles https://doi.org/10.3390/molecules13051195 2022-12-30T21:36:22Z Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentallyinduced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress. Article in Journal/Newspaper Kamchatka Kamchatka Peninsula Directory of Open Access Journals: DOAJ Articles Kamchatka Peninsula ENVELOPE(160.000,160.000,56.000,56.000) Molecules 13 5 1195 1206 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Antioxidant Lonicera caerulaea experimental tumors lipid peroxidation ceruloplasmin thiol groups Organic chemistry QD241-441 |
spellingShingle |
Antioxidant Lonicera caerulaea experimental tumors lipid peroxidation ceruloplasmin thiol groups Organic chemistry QD241-441 Ileana Cornelia Farcasanu Valentina Negoita Ion Gruia Eliza Oprea Maria Iuliana Gruia The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
topic_facet |
Antioxidant Lonicera caerulaea experimental tumors lipid peroxidation ceruloplasmin thiol groups Organic chemistry QD241-441 |
description |
Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentallyinduced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress. |
format |
Article in Journal/Newspaper |
author |
Ileana Cornelia Farcasanu Valentina Negoita Ion Gruia Eliza Oprea Maria Iuliana Gruia |
author_facet |
Ileana Cornelia Farcasanu Valentina Negoita Ion Gruia Eliza Oprea Maria Iuliana Gruia |
author_sort |
Ileana Cornelia Farcasanu |
title |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_short |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_full |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_fullStr |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_full_unstemmed |
The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors |
title_sort |
antioxidant response induced by lonicera caerulaea berry extracts in animals bearing experimental solid tumors |
publisher |
MDPI AG |
publishDate |
2008 |
url |
https://doi.org/10.3390/molecules13051195 https://doaj.org/article/480da096a2944da9a7314b30e25ed816 |
long_lat |
ENVELOPE(160.000,160.000,56.000,56.000) |
geographic |
Kamchatka Peninsula |
geographic_facet |
Kamchatka Peninsula |
genre |
Kamchatka Kamchatka Peninsula |
genre_facet |
Kamchatka Kamchatka Peninsula |
op_source |
Molecules, Vol 13, Iss 5, Pp 1195-1206 (2008) |
op_relation |
http://www.mdpi.com/1420-3049/13/5/1195/ https://doaj.org/toc/1420-3049 doi:10.3390/molecules13051195 1420-3049 https://doaj.org/article/480da096a2944da9a7314b30e25ed816 |
op_doi |
https://doi.org/10.3390/molecules13051195 |
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Molecules |
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13 |
container_issue |
5 |
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1195 |
op_container_end_page |
1206 |
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1766051303440515072 |