The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors

Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry ex...

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Bibliographic Details
Published in:Molecules
Main Authors: Ileana Cornelia Farcasanu, Valentina Negoita, Ion Gruia, Eliza Oprea, Maria Iuliana Gruia
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2008
Subjects:
Antioxidant
Lonicera caerulaea
experimental tumors
lipid peroxidation
ceruloplasmin
thiol groups
Organic chemistry
QD241-441
Kamchatka Peninsula
Kamchatka
Online Access:https://doi.org/10.3390/molecules13051195
https://doaj.org/article/480da096a2944da9a7314b30e25ed816
Description
Summary:Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentallyinduced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress.

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