Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica
The mitochondrial oxidative stress theory of aging posits that membrane susceptibility to peroxidation and the organization of the electron transport system (ETS) linked with reactive oxygen species (ROS) generation are two main drivers of lifespan. While a clear correlation has been established fro...
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ftdoajarticles:oai:doaj.org/article:4803f4ac5ea24070ae5e2bcc887ce284 2023-05-15T15:22:28+02:00 Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica Enrique Rodríguez Cyril Dégletagne Tory M. Hagen Doris Abele Pierre U. Blier 2019-07-01T00:00:00Z https://doi.org/10.3389/fphys.2019.00946 https://doaj.org/article/4803f4ac5ea24070ae5e2bcc887ce284 EN eng Frontiers Media S.A. https://www.frontiersin.org/article/10.3389/fphys.2019.00946/full https://doaj.org/toc/1664-042X 1664-042X doi:10.3389/fphys.2019.00946 https://doaj.org/article/4803f4ac5ea24070ae5e2bcc887ce284 Frontiers in Physiology, Vol 10 (2019) Arctica islandica bivalve aging model electron transport system mitochondria peroxidation index reactive oxygen species Physiology QP1-981 article 2019 ftdoajarticles https://doi.org/10.3389/fphys.2019.00946 2022-12-31T14:03:20Z The mitochondrial oxidative stress theory of aging posits that membrane susceptibility to peroxidation and the organization of the electron transport system (ETS) linked with reactive oxygen species (ROS) generation are two main drivers of lifespan. While a clear correlation has been established from species comparative studies, the significance of these characteristics as potential modulators of lifespan divergences among populations of individual species is still to be tested. The bivalve Arctica islandica, the longest-lived non-colonial animal with a record lifespan of 507 years, possesses a lower mitochondrial peroxidation index (PI) and reduced H2O2 efflux linked to complexes I and III activities than related species. Taking advantage of the wide variation in maximum reported longevities (MRL) among 6 European populations (36–507 years), we examined whether these two mitochondrial properties could explain differences in longevity. We report no relationship between membrane PI and MRL in populations of A. islandica, as well as a lack of intraspecific relationship between ETS complex activities and MRL. Individuals from brackish sites characterized by wide temperature and salinity windows had, however, markedly lower ETS enzyme activities relative to citrate synthase activity. Our results highlight environment-dependent remodeling of mitochondrial phenotypes. Article in Journal/Newspaper Arctica islandica Directory of Open Access Journals: DOAJ Articles Frontiers in Physiology 10 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctica islandica bivalve aging model electron transport system mitochondria peroxidation index reactive oxygen species Physiology QP1-981 |
spellingShingle |
Arctica islandica bivalve aging model electron transport system mitochondria peroxidation index reactive oxygen species Physiology QP1-981 Enrique Rodríguez Cyril Dégletagne Tory M. Hagen Doris Abele Pierre U. Blier Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica |
topic_facet |
Arctica islandica bivalve aging model electron transport system mitochondria peroxidation index reactive oxygen species Physiology QP1-981 |
description |
The mitochondrial oxidative stress theory of aging posits that membrane susceptibility to peroxidation and the organization of the electron transport system (ETS) linked with reactive oxygen species (ROS) generation are two main drivers of lifespan. While a clear correlation has been established from species comparative studies, the significance of these characteristics as potential modulators of lifespan divergences among populations of individual species is still to be tested. The bivalve Arctica islandica, the longest-lived non-colonial animal with a record lifespan of 507 years, possesses a lower mitochondrial peroxidation index (PI) and reduced H2O2 efflux linked to complexes I and III activities than related species. Taking advantage of the wide variation in maximum reported longevities (MRL) among 6 European populations (36–507 years), we examined whether these two mitochondrial properties could explain differences in longevity. We report no relationship between membrane PI and MRL in populations of A. islandica, as well as a lack of intraspecific relationship between ETS complex activities and MRL. Individuals from brackish sites characterized by wide temperature and salinity windows had, however, markedly lower ETS enzyme activities relative to citrate synthase activity. Our results highlight environment-dependent remodeling of mitochondrial phenotypes. |
format |
Article in Journal/Newspaper |
author |
Enrique Rodríguez Cyril Dégletagne Tory M. Hagen Doris Abele Pierre U. Blier |
author_facet |
Enrique Rodríguez Cyril Dégletagne Tory M. Hagen Doris Abele Pierre U. Blier |
author_sort |
Enrique Rodríguez |
title |
Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica |
title_short |
Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica |
title_full |
Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica |
title_fullStr |
Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica |
title_full_unstemmed |
Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica |
title_sort |
mitochondrial traits previously associated with species maximum lifespan do not correlate with longevity across populations of the bivalve arctica islandica |
publisher |
Frontiers Media S.A. |
publishDate |
2019 |
url |
https://doi.org/10.3389/fphys.2019.00946 https://doaj.org/article/4803f4ac5ea24070ae5e2bcc887ce284 |
genre |
Arctica islandica |
genre_facet |
Arctica islandica |
op_source |
Frontiers in Physiology, Vol 10 (2019) |
op_relation |
https://www.frontiersin.org/article/10.3389/fphys.2019.00946/full https://doaj.org/toc/1664-042X 1664-042X doi:10.3389/fphys.2019.00946 https://doaj.org/article/4803f4ac5ea24070ae5e2bcc887ce284 |
op_doi |
https://doi.org/10.3389/fphys.2019.00946 |
container_title |
Frontiers in Physiology |
container_volume |
10 |
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1766353121335836672 |