Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis
Abstract The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported. The potential interactions between a...
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ftdoajarticles:oai:doaj.org/article:47b7319a229a46cb9715fb3ee102ddcb 2023-05-15T15:00:15+02:00 Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis Ivanovic Jelena Gallo Anna L D'Avolio Antonio Tempestilli Massimo Bellagamba Rita Tommasi Chiara Nicastri Emanuele Pucillo Leopoldo P Narciso Pasquale 2011-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-141 https://doaj.org/article/47b7319a229a46cb9715fb3ee102ddcb EN eng BMC http://www.malariajournal.com/content/10/1/141 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-141 1475-2875 https://doaj.org/article/47b7319a229a46cb9715fb3ee102ddcb Malaria Journal, Vol 10, Iss 1, p 141 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-141 2022-12-31T04:22:03Z Abstract The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported. The potential interactions between atovaquone/proguanil and these anti-retroviral drugs are investigated. Pharmacokinetic analyses documented a marked increase in etravirine and saquinavir plasma concentrations (+55% and +274%, respectively), but not in raltegravir and maraviroc plasma concentrations. The evidence that atovaquone/proguanil significantly interacts with etravirine and saquinavir, but not with raltegravir and maraviroc, suggests that the mechanism of interaction is related to cytochrome P450. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ivanovic Jelena Gallo Anna L D'Avolio Antonio Tempestilli Massimo Bellagamba Rita Tommasi Chiara Nicastri Emanuele Pucillo Leopoldo P Narciso Pasquale Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported. The potential interactions between atovaquone/proguanil and these anti-retroviral drugs are investigated. Pharmacokinetic analyses documented a marked increase in etravirine and saquinavir plasma concentrations (+55% and +274%, respectively), but not in raltegravir and maraviroc plasma concentrations. The evidence that atovaquone/proguanil significantly interacts with etravirine and saquinavir, but not with raltegravir and maraviroc, suggests that the mechanism of interaction is related to cytochrome P450. |
format |
Article in Journal/Newspaper |
author |
Ivanovic Jelena Gallo Anna L D'Avolio Antonio Tempestilli Massimo Bellagamba Rita Tommasi Chiara Nicastri Emanuele Pucillo Leopoldo P Narciso Pasquale |
author_facet |
Ivanovic Jelena Gallo Anna L D'Avolio Antonio Tempestilli Massimo Bellagamba Rita Tommasi Chiara Nicastri Emanuele Pucillo Leopoldo P Narciso Pasquale |
author_sort |
Ivanovic Jelena |
title |
Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis |
title_short |
Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis |
title_full |
Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis |
title_fullStr |
Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis |
title_full_unstemmed |
Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis |
title_sort |
marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-141 https://doaj.org/article/47b7319a229a46cb9715fb3ee102ddcb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 141 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/141 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-141 1475-2875 https://doaj.org/article/47b7319a229a46cb9715fb3ee102ddcb |
op_doi |
https://doi.org/10.1186/1475-2875-10-141 |
container_title |
Malaria Journal |
container_volume |
10 |
container_issue |
1 |
_version_ |
1766332357237800960 |