Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19
Abstract Recent reports indicate that besides respiratory and systemic symptoms among coronavirus disease (COVID-19) patients, the disease has a wide spectrum of neurological manifestations (encephalitis, meningitis, myelitis, acute disseminated encephalomyelitis, metabolic and acute hemorrhagic nec...
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ftdoajarticles:oai:doaj.org/article:47a7e27921974d8da119ce9eff2f57dc 2023-05-15T15:04:25+02:00 Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 Marzia Puccioni-Sohler André Rodrigues Poton Milena Franklin Samya Jezine da Silva Rodrigo Brindeiro Amilcar Tanuri 2020-10-01T00:00:00Z https://doi.org/10.1590/0037-8682-0477-2020 https://doaj.org/article/47a7e27921974d8da119ce9eff2f57dc EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100252&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0477-2020 https://doaj.org/article/47a7e27921974d8da119ce9eff2f57dc Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) SARS-CoV-2 Coronavirus disease Neuropathogenesis Nervous system Cerebrospinal fluid Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1590/0037-8682-0477-2020 2022-12-30T23:24:18Z Abstract Recent reports indicate that besides respiratory and systemic symptoms among coronavirus disease (COVID-19) patients, the disease has a wide spectrum of neurological manifestations (encephalitis, meningitis, myelitis, acute disseminated encephalomyelitis, metabolic and acute hemorrhagic necrotizing encephalopathy, cerebrovascular diseases, Guillain-Barré syndrome, polyneuritis cranialis, dysautonomia, and myopathies). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread from the respiratory system to the central nervous system, using transneuronal and hematogenous mechanisms. Although not every COVID-19 patient will test positive for the virus in the cerebrospinal fluid exam, the appearance of neurological symptoms associated with SARS-CoV-2 infection reveals the importance of understanding the neurologic manifestations and capacity for neural invasion associated with the pathogen. These aspects are relevant for correct diagnosis and treatment, and for the potential development of vaccines. This review highlights the latest evidence of SARS-CoV-2 infection with a focus on neurological involvement and potential neuropathogenesis mechanisms. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) Revista da Sociedade Brasileira de Medicina Tropical 53 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
SARS-CoV-2 Coronavirus disease Neuropathogenesis Nervous system Cerebrospinal fluid Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
SARS-CoV-2 Coronavirus disease Neuropathogenesis Nervous system Cerebrospinal fluid Arctic medicine. Tropical medicine RC955-962 Marzia Puccioni-Sohler André Rodrigues Poton Milena Franklin Samya Jezine da Silva Rodrigo Brindeiro Amilcar Tanuri Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
topic_facet |
SARS-CoV-2 Coronavirus disease Neuropathogenesis Nervous system Cerebrospinal fluid Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Recent reports indicate that besides respiratory and systemic symptoms among coronavirus disease (COVID-19) patients, the disease has a wide spectrum of neurological manifestations (encephalitis, meningitis, myelitis, acute disseminated encephalomyelitis, metabolic and acute hemorrhagic necrotizing encephalopathy, cerebrovascular diseases, Guillain-Barré syndrome, polyneuritis cranialis, dysautonomia, and myopathies). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread from the respiratory system to the central nervous system, using transneuronal and hematogenous mechanisms. Although not every COVID-19 patient will test positive for the virus in the cerebrospinal fluid exam, the appearance of neurological symptoms associated with SARS-CoV-2 infection reveals the importance of understanding the neurologic manifestations and capacity for neural invasion associated with the pathogen. These aspects are relevant for correct diagnosis and treatment, and for the potential development of vaccines. This review highlights the latest evidence of SARS-CoV-2 infection with a focus on neurological involvement and potential neuropathogenesis mechanisms. |
format |
Article in Journal/Newspaper |
author |
Marzia Puccioni-Sohler André Rodrigues Poton Milena Franklin Samya Jezine da Silva Rodrigo Brindeiro Amilcar Tanuri |
author_facet |
Marzia Puccioni-Sohler André Rodrigues Poton Milena Franklin Samya Jezine da Silva Rodrigo Brindeiro Amilcar Tanuri |
author_sort |
Marzia Puccioni-Sohler |
title |
Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_short |
Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_full |
Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_fullStr |
Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_full_unstemmed |
Current evidence of neurological features, diagnosis, and neuropathogenesis associated with COVID-19 |
title_sort |
current evidence of neurological features, diagnosis, and neuropathogenesis associated with covid-19 |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2020 |
url |
https://doi.org/10.1590/0037-8682-0477-2020 https://doaj.org/article/47a7e27921974d8da119ce9eff2f57dc |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100252&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0477-2020 https://doaj.org/article/47a7e27921974d8da119ce9eff2f57dc |
op_doi |
https://doi.org/10.1590/0037-8682-0477-2020 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
53 |
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