IgG1 as a potential biomarker of post-chemotherapeutic relapse in visceral leishmaniasis, and adaptation to a rapid diagnostic test.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Tapan Bhattacharyya, Armon Ayandeh, Andrew K Falconar, Shyam Sundar, Sayda El-Safi, Marissa A Gripenberg, Duncan E Bowes, Caroline Thunissen, Om Prakash Singh, Rajiv Kumar, Osman Ahmed, Osama Eisa, Alfarazdeg Saad, Sara Silva Pereira, Marleen Boelaert, Pascal Mertens, Michael A Miles
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2014
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Azar; Indian
• Online Access: https://doi.org/10.1371/journal.pntd.0003273; https://doaj.org/article/478f2acb1fec4ec7a5db4327c5ceac98

BACKGROUND: Visceral leishmaniasis (VL), caused by protozoa of the Leishmania donovani complex, is a widespread parasitic disease of great public health importance; without effective chemotherapy symptomatic VL is usually fatal. Distinction of asymptomatic carriage from progressive disease and the p...