CystiSim - An Agent-Based Model for Taenia solium Transmission and Control.
Taenia solium taeniosis/cysticercosis was declared eradicable by the International Task Force for Disease Eradication in 1993, but remains a neglected zoonosis. To assist in the attempt to regionally eliminate this parasite, we developed cystiSim, an agent-based model for T. solium transmission and...
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ftdoajarticles:oai:doaj.org/article:4783436397ac4ef68014331fb6d60f93 2023-05-15T15:14:45+02:00 CystiSim - An Agent-Based Model for Taenia solium Transmission and Control. Uffe Christian Braae Brecht Devleesschauwer Sarah Gabriël Pierre Dorny Niko Speybroeck Pascal Magnussen Paul Torgerson Maria Vang Johansen 2016-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005184 https://doaj.org/article/4783436397ac4ef68014331fb6d60f93 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5161321?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005184 https://doaj.org/article/4783436397ac4ef68014331fb6d60f93 PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005184 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005184 2022-12-31T03:27:47Z Taenia solium taeniosis/cysticercosis was declared eradicable by the International Task Force for Disease Eradication in 1993, but remains a neglected zoonosis. To assist in the attempt to regionally eliminate this parasite, we developed cystiSim, an agent-based model for T. solium transmission and control. The model was developed in R and available as an R package (http://cran.r-project.org/package=cystiSim). cystiSim was adapted to an observed setting using field data from Tanzania, but adaptable to other settings if necessary. The model description adheres to the Overview, Design concepts, and Details (ODD) protocol and consists of two entities-pigs and humans. Pigs acquire cysticercosis through the environment or by direct contact with a tapeworm carrier's faeces. Humans acquire taeniosis from slaughtered pigs proportional to their infection intensity. The model allows for evaluation of three interventions measures or combinations hereof: treatment of humans, treatment of pigs, and pig vaccination, and allows for customary coverage and efficacy settings. cystiSim is the first agent-based transmission model for T. solium and suggests that control using a strategy consisting of an intervention only targeting the porcine host is possible, but that coverage and efficacy must be high if elimination is the ultimate goal. Good coverage of the intervention is important, but can be compensated for by including an additional intervention targeting the human host. cystiSim shows that the scenarios combining interventions in both hosts, mass drug administration to humans, and vaccination and treatment of pigs, have a high probability of success if coverage of 75% can be maintained over at least a four year period. In comparison with an existing mathematical model for T. solium transmission, cystiSim also includes parasite maturation, host immunity, and environmental contamination. Adding these biological parameters to the model resulted in new insights in the potential effect of intervention measures. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 12 e0005184 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Uffe Christian Braae Brecht Devleesschauwer Sarah Gabriël Pierre Dorny Niko Speybroeck Pascal Magnussen Paul Torgerson Maria Vang Johansen CystiSim - An Agent-Based Model for Taenia solium Transmission and Control. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Taenia solium taeniosis/cysticercosis was declared eradicable by the International Task Force for Disease Eradication in 1993, but remains a neglected zoonosis. To assist in the attempt to regionally eliminate this parasite, we developed cystiSim, an agent-based model for T. solium transmission and control. The model was developed in R and available as an R package (http://cran.r-project.org/package=cystiSim). cystiSim was adapted to an observed setting using field data from Tanzania, but adaptable to other settings if necessary. The model description adheres to the Overview, Design concepts, and Details (ODD) protocol and consists of two entities-pigs and humans. Pigs acquire cysticercosis through the environment or by direct contact with a tapeworm carrier's faeces. Humans acquire taeniosis from slaughtered pigs proportional to their infection intensity. The model allows for evaluation of three interventions measures or combinations hereof: treatment of humans, treatment of pigs, and pig vaccination, and allows for customary coverage and efficacy settings. cystiSim is the first agent-based transmission model for T. solium and suggests that control using a strategy consisting of an intervention only targeting the porcine host is possible, but that coverage and efficacy must be high if elimination is the ultimate goal. Good coverage of the intervention is important, but can be compensated for by including an additional intervention targeting the human host. cystiSim shows that the scenarios combining interventions in both hosts, mass drug administration to humans, and vaccination and treatment of pigs, have a high probability of success if coverage of 75% can be maintained over at least a four year period. In comparison with an existing mathematical model for T. solium transmission, cystiSim also includes parasite maturation, host immunity, and environmental contamination. Adding these biological parameters to the model resulted in new insights in the potential effect of intervention measures. |
format |
Article in Journal/Newspaper |
author |
Uffe Christian Braae Brecht Devleesschauwer Sarah Gabriël Pierre Dorny Niko Speybroeck Pascal Magnussen Paul Torgerson Maria Vang Johansen |
author_facet |
Uffe Christian Braae Brecht Devleesschauwer Sarah Gabriël Pierre Dorny Niko Speybroeck Pascal Magnussen Paul Torgerson Maria Vang Johansen |
author_sort |
Uffe Christian Braae |
title |
CystiSim - An Agent-Based Model for Taenia solium Transmission and Control. |
title_short |
CystiSim - An Agent-Based Model for Taenia solium Transmission and Control. |
title_full |
CystiSim - An Agent-Based Model for Taenia solium Transmission and Control. |
title_fullStr |
CystiSim - An Agent-Based Model for Taenia solium Transmission and Control. |
title_full_unstemmed |
CystiSim - An Agent-Based Model for Taenia solium Transmission and Control. |
title_sort |
cystisim - an agent-based model for taenia solium transmission and control. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005184 https://doaj.org/article/4783436397ac4ef68014331fb6d60f93 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005184 (2016) |
op_relation |
http://europepmc.org/articles/PMC5161321?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005184 https://doaj.org/article/4783436397ac4ef68014331fb6d60f93 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005184 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
12 |
container_start_page |
e0005184 |
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1766345168264364032 |