Neglected scrub typhus: An updated review with a focus on omics technologies
Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people w...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:4781e24815eb480fb58a132a79cc6541 2023-05-15T15:04:00+02:00 Neglected scrub typhus: An updated review with a focus on omics technologies Dixit Sharma Ankita Sharma Birbal Singh Sunil Kumar Shailender Kumar Verma 2022-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.364003 https://doaj.org/article/4781e24815eb480fb58a132a79cc6541 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=12;spage=531;epage=541;aulast=Sharma https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.364003 https://doaj.org/article/4781e24815eb480fb58a132a79cc6541 Asian Pacific Journal of Tropical Medicine, Vol 15, Iss 12, Pp 531-541 (2022) orientia tsutsugamushi scrub typhus therapeutic targets omics technologies drug discovery Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.4103/1995-7645.364003 2023-01-15T01:25:47Z Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted. Article in Journal/Newspaper Arctic Mite Directory of Open Access Journals: DOAJ Articles Arctic Pacific Asian Pacific Journal of Tropical Medicine 15 12 531 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
orientia tsutsugamushi scrub typhus therapeutic targets omics technologies drug discovery Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
orientia tsutsugamushi scrub typhus therapeutic targets omics technologies drug discovery Arctic medicine. Tropical medicine RC955-962 Dixit Sharma Ankita Sharma Birbal Singh Sunil Kumar Shailender Kumar Verma Neglected scrub typhus: An updated review with a focus on omics technologies |
topic_facet |
orientia tsutsugamushi scrub typhus therapeutic targets omics technologies drug discovery Arctic medicine. Tropical medicine RC955-962 |
description |
Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted. |
format |
Article in Journal/Newspaper |
author |
Dixit Sharma Ankita Sharma Birbal Singh Sunil Kumar Shailender Kumar Verma |
author_facet |
Dixit Sharma Ankita Sharma Birbal Singh Sunil Kumar Shailender Kumar Verma |
author_sort |
Dixit Sharma |
title |
Neglected scrub typhus: An updated review with a focus on omics technologies |
title_short |
Neglected scrub typhus: An updated review with a focus on omics technologies |
title_full |
Neglected scrub typhus: An updated review with a focus on omics technologies |
title_fullStr |
Neglected scrub typhus: An updated review with a focus on omics technologies |
title_full_unstemmed |
Neglected scrub typhus: An updated review with a focus on omics technologies |
title_sort |
neglected scrub typhus: an updated review with a focus on omics technologies |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2022 |
url |
https://doi.org/10.4103/1995-7645.364003 https://doaj.org/article/4781e24815eb480fb58a132a79cc6541 |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic Mite |
genre_facet |
Arctic Mite |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 15, Iss 12, Pp 531-541 (2022) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=12;spage=531;epage=541;aulast=Sharma https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.364003 https://doaj.org/article/4781e24815eb480fb58a132a79cc6541 |
op_doi |
https://doi.org/10.4103/1995-7645.364003 |
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Asian Pacific Journal of Tropical Medicine |
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15 |
container_issue |
12 |
container_start_page |
531 |
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1766335844235345920 |