Meningococcal Disease Caused by Neisseria meningitidis Serogroup B Serotype 4 in São Paulo, Brazil, 1990 to 1996
A large epidemic of serogroup B meningococcal disease (MD), has been occurring in greater São Paulo, Brazil, since 1988.21 A Cuban-produced vaccine, based on outer-membrane-protein (OMP) from serogroup B: serotype 4: serosubtype P1.15 (B:4:P1.15) Neisseria meningitidis, was given to about 2.4 millio...
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ftdoajarticles:oai:doaj.org/article:4763b953fe50464b8d19a0aa4416bb5b 2024-09-09T19:26:44+00:00 Meningococcal Disease Caused by Neisseria meningitidis Serogroup B Serotype 4 in São Paulo, Brazil, 1990 to 1996 Claudio Tavares Sacchi Ana Paula Silva de Lemos Maria Claudia C. Camargo Anne M. Whitney Carmo Elias A. Melles Claude André Solari Carl E. Frasch Leonard W. Mayer 1998-03-01T00:00:00Z https://doaj.org/article/4763b953fe50464b8d19a0aa4416bb5b EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000200001&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/4763b953fe50464b8d19a0aa4416bb5b Revista do Instituto de Medicina Tropical de São Paulo, Vol 40, Iss 2, Pp 65-70 (1998) Neisseria meningitidis: Ribotyping Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1998 ftdoajarticles 2024-08-05T17:49:31Z A large epidemic of serogroup B meningococcal disease (MD), has been occurring in greater São Paulo, Brazil, since 1988.21 A Cuban-produced vaccine, based on outer-membrane-protein (OMP) from serogroup B: serotype 4: serosubtype P1.15 (B:4:P1.15) Neisseria meningitidis, was given to about 2.4 million children aged from 3 months to 6 years during 1989 and 1990. The administration of vaccine had little or no measurable effects on this outbreak. In order to detect clonal changes that could explain the continued increase in the incidence of disease after the vaccination, we serotyped isolates recovered between 1990 and 1996 from 834 patients with systemic disease. Strains B:4:P1.15, which was detected in the area as early as 1977, has been the most prevalent phenotype since 1988. These strains are still prevalent in the area and were responsible for about 68% of 834 serogroup B cases in the last 7 years. We analyzed 438 (52%) of these strains by restriction fragment length polymorphism (RFLPs) of rRNA genes (ribotyping). The most frequent pattern obtained was referred to as Rb1 (68%). We concluded that the same clone of B:4:P1.15-Rb1 strains was the most prevalent strain and responsible for the continued increase of incidence of serogroup B MD cases in greater São Paulo during the last 7 years in spite of the vaccination trial. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Neisseria meningitidis: Ribotyping Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Neisseria meningitidis: Ribotyping Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Claudio Tavares Sacchi Ana Paula Silva de Lemos Maria Claudia C. Camargo Anne M. Whitney Carmo Elias A. Melles Claude André Solari Carl E. Frasch Leonard W. Mayer Meningococcal Disease Caused by Neisseria meningitidis Serogroup B Serotype 4 in São Paulo, Brazil, 1990 to 1996 |
topic_facet |
Neisseria meningitidis: Ribotyping Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A large epidemic of serogroup B meningococcal disease (MD), has been occurring in greater São Paulo, Brazil, since 1988.21 A Cuban-produced vaccine, based on outer-membrane-protein (OMP) from serogroup B: serotype 4: serosubtype P1.15 (B:4:P1.15) Neisseria meningitidis, was given to about 2.4 million children aged from 3 months to 6 years during 1989 and 1990. The administration of vaccine had little or no measurable effects on this outbreak. In order to detect clonal changes that could explain the continued increase in the incidence of disease after the vaccination, we serotyped isolates recovered between 1990 and 1996 from 834 patients with systemic disease. Strains B:4:P1.15, which was detected in the area as early as 1977, has been the most prevalent phenotype since 1988. These strains are still prevalent in the area and were responsible for about 68% of 834 serogroup B cases in the last 7 years. We analyzed 438 (52%) of these strains by restriction fragment length polymorphism (RFLPs) of rRNA genes (ribotyping). The most frequent pattern obtained was referred to as Rb1 (68%). We concluded that the same clone of B:4:P1.15-Rb1 strains was the most prevalent strain and responsible for the continued increase of incidence of serogroup B MD cases in greater São Paulo during the last 7 years in spite of the vaccination trial. |
format |
Article in Journal/Newspaper |
author |
Claudio Tavares Sacchi Ana Paula Silva de Lemos Maria Claudia C. Camargo Anne M. Whitney Carmo Elias A. Melles Claude André Solari Carl E. Frasch Leonard W. Mayer |
author_facet |
Claudio Tavares Sacchi Ana Paula Silva de Lemos Maria Claudia C. Camargo Anne M. Whitney Carmo Elias A. Melles Claude André Solari Carl E. Frasch Leonard W. Mayer |
author_sort |
Claudio Tavares Sacchi |
title |
Meningococcal Disease Caused by Neisseria meningitidis Serogroup B Serotype 4 in São Paulo, Brazil, 1990 to 1996 |
title_short |
Meningococcal Disease Caused by Neisseria meningitidis Serogroup B Serotype 4 in São Paulo, Brazil, 1990 to 1996 |
title_full |
Meningococcal Disease Caused by Neisseria meningitidis Serogroup B Serotype 4 in São Paulo, Brazil, 1990 to 1996 |
title_fullStr |
Meningococcal Disease Caused by Neisseria meningitidis Serogroup B Serotype 4 in São Paulo, Brazil, 1990 to 1996 |
title_full_unstemmed |
Meningococcal Disease Caused by Neisseria meningitidis Serogroup B Serotype 4 in São Paulo, Brazil, 1990 to 1996 |
title_sort |
meningococcal disease caused by neisseria meningitidis serogroup b serotype 4 in são paulo, brazil, 1990 to 1996 |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1998 |
url |
https://doaj.org/article/4763b953fe50464b8d19a0aa4416bb5b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 40, Iss 2, Pp 65-70 (1998) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000200001&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/4763b953fe50464b8d19a0aa4416bb5b |
_version_ |
1809896286581686272 |