Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia
The research objective was to study the association of the ACE gene I/D polymorphism with essential hypertension (EH) and metabolic risk factors among indigenous people of the northern territory of Yakutia. The obtained data show that representatives of indigenous people of the North of Yakutia with...
Published in: | International Journal of Biomedicine |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
International Medical Research and Development Corporation
2019
|
Subjects: | |
Online Access: | https://doi.org/10.21103/Article9(2)_OA3 https://doaj.org/article/46e7226204ef4d5a8580187888fd58ae |
id |
ftdoajarticles:oai:doaj.org/article:46e7226204ef4d5a8580187888fd58ae |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:46e7226204ef4d5a8580187888fd58ae 2023-05-15T18:44:43+02:00 Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia Sargylana I. Sofronova Maria P. Kirillina Vyacheslav M. Nikolaev Sardaana K. Kononova Oksana G. Sidorova Anna N. Romanova 2019-06-01T00:00:00Z https://doi.org/10.21103/Article9(2)_OA3 https://doaj.org/article/46e7226204ef4d5a8580187888fd58ae EN eng International Medical Research and Development Corporation http://ijbm.org/articles/IJBM_9(2)_OA3.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article9(2)_OA3 2158-0510 2158-0529 https://doaj.org/article/46e7226204ef4d5a8580187888fd58ae International Journal of Biomedicine, Vol 9, Iss 2, Pp 102-105 (2019) essential hypertension ACE gene indigenous people risk factors Medicine R article 2019 ftdoajarticles https://doi.org/10.21103/Article9(2)_OA3 2022-12-31T00:38:54Z The research objective was to study the association of the ACE gene I/D polymorphism with essential hypertension (EH) and metabolic risk factors among indigenous people of the northern territory of Yakutia. The obtained data show that representatives of indigenous people of the North of Yakutia with the ACE ID genotype are characterized with high levels of systolic blood pressure. The carriage of DD genotype in EH patients is associated with a high frequency of hypercholesterolemia and hyper-LDL cholesterolemia. The carriage of ID genotype in EH patients, compared to subjects without EH, is characterized by higher blood levels of TC, LDL-C, TG, and FPG and associated with a high frequency of obesity. Thus, the ACE I/D polymorphism was found to be associated with metabolic risk factors in indigenous EH patients of the North of Yakutia. Article in Journal/Newspaper Yakutia Directory of Open Access Journals: DOAJ Articles International Journal of Biomedicine 9 2 102 105 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
essential hypertension ACE gene indigenous people risk factors Medicine R |
spellingShingle |
essential hypertension ACE gene indigenous people risk factors Medicine R Sargylana I. Sofronova Maria P. Kirillina Vyacheslav M. Nikolaev Sardaana K. Kononova Oksana G. Sidorova Anna N. Romanova Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia |
topic_facet |
essential hypertension ACE gene indigenous people risk factors Medicine R |
description |
The research objective was to study the association of the ACE gene I/D polymorphism with essential hypertension (EH) and metabolic risk factors among indigenous people of the northern territory of Yakutia. The obtained data show that representatives of indigenous people of the North of Yakutia with the ACE ID genotype are characterized with high levels of systolic blood pressure. The carriage of DD genotype in EH patients is associated with a high frequency of hypercholesterolemia and hyper-LDL cholesterolemia. The carriage of ID genotype in EH patients, compared to subjects without EH, is characterized by higher blood levels of TC, LDL-C, TG, and FPG and associated with a high frequency of obesity. Thus, the ACE I/D polymorphism was found to be associated with metabolic risk factors in indigenous EH patients of the North of Yakutia. |
format |
Article in Journal/Newspaper |
author |
Sargylana I. Sofronova Maria P. Kirillina Vyacheslav M. Nikolaev Sardaana K. Kononova Oksana G. Sidorova Anna N. Romanova |
author_facet |
Sargylana I. Sofronova Maria P. Kirillina Vyacheslav M. Nikolaev Sardaana K. Kononova Oksana G. Sidorova Anna N. Romanova |
author_sort |
Sargylana I. Sofronova |
title |
Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia |
title_short |
Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia |
title_full |
Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia |
title_fullStr |
Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia |
title_full_unstemmed |
Association of ACE Gene Polymorphism with Hypertension and Metabolic Risk Factors among Indigenous People of the Northern Territory of Yakutia |
title_sort |
association of ace gene polymorphism with hypertension and metabolic risk factors among indigenous people of the northern territory of yakutia |
publisher |
International Medical Research and Development Corporation |
publishDate |
2019 |
url |
https://doi.org/10.21103/Article9(2)_OA3 https://doaj.org/article/46e7226204ef4d5a8580187888fd58ae |
genre |
Yakutia |
genre_facet |
Yakutia |
op_source |
International Journal of Biomedicine, Vol 9, Iss 2, Pp 102-105 (2019) |
op_relation |
http://ijbm.org/articles/IJBM_9(2)_OA3.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article9(2)_OA3 2158-0510 2158-0529 https://doaj.org/article/46e7226204ef4d5a8580187888fd58ae |
op_doi |
https://doi.org/10.21103/Article9(2)_OA3 |
container_title |
International Journal of Biomedicine |
container_volume |
9 |
container_issue |
2 |
container_start_page |
102 |
op_container_end_page |
105 |
_version_ |
1766235536023879680 |