MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection.
Dengue virus (DENV) and Zika virus (ZIKV) are members of the Flaviviridae and are predominantly transmitted via mosquito bites. Both viruses are responsible for a growing number of infections in tropical and subtropical regions. DENV infection can cause lethargy with severe morbidity and dengue shoc...
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Online Access: | https://doi.org/10.1371/journal.pntd.0006154 https://doaj.org/article/462d5e55696e45e984b07e3b74d62a4e |
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ftdoajarticles:oai:doaj.org/article:462d5e55696e45e984b07e3b74d62a4e 2023-05-15T15:09:58+02:00 MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. Dominic Paquin-Proulx Vivian I Avelino-Silva Bianca A N Santos Nathália Silveira Barsotti Fabiana Siroma Jessica Fernandes Ramos Adriana Coracini Tonacio Alice Song Alvino Maestri Natalia Barros Cerqueira Alvina Clara Felix José Eduardo Levi Benjamin C Greenspun Miguel de Mulder Rougvie Michael G Rosenberg Douglas F Nixon Esper G Kallas 2018-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006154 https://doaj.org/article/462d5e55696e45e984b07e3b74d62a4e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5794195?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006154 https://doaj.org/article/462d5e55696e45e984b07e3b74d62a4e PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006154 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006154 2022-12-31T02:11:25Z Dengue virus (DENV) and Zika virus (ZIKV) are members of the Flaviviridae and are predominantly transmitted via mosquito bites. Both viruses are responsible for a growing number of infections in tropical and subtropical regions. DENV infection can cause lethargy with severe morbidity and dengue shock syndrome leading to death in some cases. ZIKV is now linked with Guillain-Barré syndrome and fetal malformations including microcephaly and developmental disorders (congenital Zika syndrome). The protective and pathogenic roles played by the immune response in these infections is unknown. Mucosal-associated invariant T (MAIT) cells are a population of innate T cells with potent anti-bacterial activity. MAIT cells have also been postulated to play a role in the immune response to viral infections. In this study, we evaluated MAIT cell frequency, phenotype, and function in samples from subjects with acute and convalescent DENV infection. We found that in acute DENV infection, MAIT cells had elevated co-expression of the activation markers CD38 and HLA-DR and had a poor IFNγ response following bacterial stimulation. Furthermore, we found that MAIT cells can produce IFNγ in response to in vitro infection with ZIKV. This MAIT cell response was independent of MR1, but dependent on IL-12 and IL-18. Our results suggest that MAIT cells may play an important role in the immune response to Flavivirus infections. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) PLOS Neglected Tropical Diseases 12 1 e0006154 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Dominic Paquin-Proulx Vivian I Avelino-Silva Bianca A N Santos Nathália Silveira Barsotti Fabiana Siroma Jessica Fernandes Ramos Adriana Coracini Tonacio Alice Song Alvino Maestri Natalia Barros Cerqueira Alvina Clara Felix José Eduardo Levi Benjamin C Greenspun Miguel de Mulder Rougvie Michael G Rosenberg Douglas F Nixon Esper G Kallas MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue virus (DENV) and Zika virus (ZIKV) are members of the Flaviviridae and are predominantly transmitted via mosquito bites. Both viruses are responsible for a growing number of infections in tropical and subtropical regions. DENV infection can cause lethargy with severe morbidity and dengue shock syndrome leading to death in some cases. ZIKV is now linked with Guillain-Barré syndrome and fetal malformations including microcephaly and developmental disorders (congenital Zika syndrome). The protective and pathogenic roles played by the immune response in these infections is unknown. Mucosal-associated invariant T (MAIT) cells are a population of innate T cells with potent anti-bacterial activity. MAIT cells have also been postulated to play a role in the immune response to viral infections. In this study, we evaluated MAIT cell frequency, phenotype, and function in samples from subjects with acute and convalescent DENV infection. We found that in acute DENV infection, MAIT cells had elevated co-expression of the activation markers CD38 and HLA-DR and had a poor IFNγ response following bacterial stimulation. Furthermore, we found that MAIT cells can produce IFNγ in response to in vitro infection with ZIKV. This MAIT cell response was independent of MR1, but dependent on IL-12 and IL-18. Our results suggest that MAIT cells may play an important role in the immune response to Flavivirus infections. |
format |
Article in Journal/Newspaper |
author |
Dominic Paquin-Proulx Vivian I Avelino-Silva Bianca A N Santos Nathália Silveira Barsotti Fabiana Siroma Jessica Fernandes Ramos Adriana Coracini Tonacio Alice Song Alvino Maestri Natalia Barros Cerqueira Alvina Clara Felix José Eduardo Levi Benjamin C Greenspun Miguel de Mulder Rougvie Michael G Rosenberg Douglas F Nixon Esper G Kallas |
author_facet |
Dominic Paquin-Proulx Vivian I Avelino-Silva Bianca A N Santos Nathália Silveira Barsotti Fabiana Siroma Jessica Fernandes Ramos Adriana Coracini Tonacio Alice Song Alvino Maestri Natalia Barros Cerqueira Alvina Clara Felix José Eduardo Levi Benjamin C Greenspun Miguel de Mulder Rougvie Michael G Rosenberg Douglas F Nixon Esper G Kallas |
author_sort |
Dominic Paquin-Proulx |
title |
MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. |
title_short |
MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. |
title_full |
MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. |
title_fullStr |
MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. |
title_full_unstemmed |
MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection. |
title_sort |
mait cells are activated in acute dengue virus infection and after in vitro zika virus infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006154 https://doaj.org/article/462d5e55696e45e984b07e3b74d62a4e |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006154 (2018) |
op_relation |
http://europepmc.org/articles/PMC5794195?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006154 https://doaj.org/article/462d5e55696e45e984b07e3b74d62a4e |
op_doi |
https://doi.org/10.1371/journal.pntd.0006154 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
1 |
container_start_page |
e0006154 |
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1766341059392045056 |