Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis
Abstract Flatfish undergo a remarkable metamorphosis from symmetrical pelagic larvae to fully asymmetrical benthic juveniles. The most distinctive features of this transformation is the migration of one eye. The molecular role of thyroid hormone in the metamorphosis process in flatfishes is well est...
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ftdoajarticles:oai:doaj.org/article:460883d311f44718aebe38b25c2e2c0d 2024-09-09T20:12:33+00:00 Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis Laura Guerrero-Peña Paula Suarez-Bregua Lucía Sánchez-Ruiloba Luis Méndez-Martínez Pablo García-Fernández Ricardo Tur Juan J. Tena Josep Rotllant 2024-03-01T00:00:00Z https://doi.org/10.1038/s42003-024-05951-x https://doaj.org/article/460883d311f44718aebe38b25c2e2c0d EN eng Nature Portfolio https://doi.org/10.1038/s42003-024-05951-x https://doaj.org/toc/2399-3642 doi:10.1038/s42003-024-05951-x 2399-3642 https://doaj.org/article/460883d311f44718aebe38b25c2e2c0d Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024) Biology (General) QH301-705.5 article 2024 ftdoajarticles https://doi.org/10.1038/s42003-024-05951-x 2024-08-05T17:49:52Z Abstract Flatfish undergo a remarkable metamorphosis from symmetrical pelagic larvae to fully asymmetrical benthic juveniles. The most distinctive features of this transformation is the migration of one eye. The molecular role of thyroid hormone in the metamorphosis process in flatfishes is well established. However, the regulatory network that facilitates eye movement remains enigmatic. This paper presents a morphological investigation of the metamorphic process in turbot eyes, using advanced imaging techniques and a global view of gene expression. The study covers migrant and non-migrant eyes and aims to identify the genes that are active during ocular migration. Our transcriptomic analysis shows a significant up-regulation of immune-related genes. The analysis of eye-specific genes reveals distinct patterns during the metamorphic process. Myosin is highlighted in the non-migrant eye, while ependymin is highlighted in the migrant eye, possibly involved in optic nerve regeneration. Furthermore, a potential association between the alx3 gene and cranial restructuring has been identified. Additionally, it confirmed simultaneous adaptation to low light in both eyes, as described by changes in opsins expression during the metamorphic process. The study also revealed that ocular migration activates systems asynchronously in both eyes, providing insight into multifaceted reorganization processes during metamorphosis of flatfish. Article in Journal/Newspaper Turbot Directory of Open Access Journals: DOAJ Articles Communications Biology 7 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Laura Guerrero-Peña Paula Suarez-Bregua Lucía Sánchez-Ruiloba Luis Méndez-Martínez Pablo García-Fernández Ricardo Tur Juan J. Tena Josep Rotllant Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis |
topic_facet |
Biology (General) QH301-705.5 |
description |
Abstract Flatfish undergo a remarkable metamorphosis from symmetrical pelagic larvae to fully asymmetrical benthic juveniles. The most distinctive features of this transformation is the migration of one eye. The molecular role of thyroid hormone in the metamorphosis process in flatfishes is well established. However, the regulatory network that facilitates eye movement remains enigmatic. This paper presents a morphological investigation of the metamorphic process in turbot eyes, using advanced imaging techniques and a global view of gene expression. The study covers migrant and non-migrant eyes and aims to identify the genes that are active during ocular migration. Our transcriptomic analysis shows a significant up-regulation of immune-related genes. The analysis of eye-specific genes reveals distinct patterns during the metamorphic process. Myosin is highlighted in the non-migrant eye, while ependymin is highlighted in the migrant eye, possibly involved in optic nerve regeneration. Furthermore, a potential association between the alx3 gene and cranial restructuring has been identified. Additionally, it confirmed simultaneous adaptation to low light in both eyes, as described by changes in opsins expression during the metamorphic process. The study also revealed that ocular migration activates systems asynchronously in both eyes, providing insight into multifaceted reorganization processes during metamorphosis of flatfish. |
format |
Article in Journal/Newspaper |
author |
Laura Guerrero-Peña Paula Suarez-Bregua Lucía Sánchez-Ruiloba Luis Méndez-Martínez Pablo García-Fernández Ricardo Tur Juan J. Tena Josep Rotllant |
author_facet |
Laura Guerrero-Peña Paula Suarez-Bregua Lucía Sánchez-Ruiloba Luis Méndez-Martínez Pablo García-Fernández Ricardo Tur Juan J. Tena Josep Rotllant |
author_sort |
Laura Guerrero-Peña |
title |
Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis |
title_short |
Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis |
title_full |
Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis |
title_fullStr |
Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis |
title_full_unstemmed |
Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis |
title_sort |
unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis |
publisher |
Nature Portfolio |
publishDate |
2024 |
url |
https://doi.org/10.1038/s42003-024-05951-x https://doaj.org/article/460883d311f44718aebe38b25c2e2c0d |
genre |
Turbot |
genre_facet |
Turbot |
op_source |
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024) |
op_relation |
https://doi.org/10.1038/s42003-024-05951-x https://doaj.org/toc/2399-3642 doi:10.1038/s42003-024-05951-x 2399-3642 https://doaj.org/article/460883d311f44718aebe38b25c2e2c0d |
op_doi |
https://doi.org/10.1038/s42003-024-05951-x |
container_title |
Communications Biology |
container_volume |
7 |
container_issue |
1 |
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1809947135298240512 |