Total Phenolic Fraction (TPF) from Extra Virgin Olive Oil: Induction of apoptotic-like cell death in Leishmania spp. promastigotes and in vivo potential of therapeutic immunomodulation.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Kalliopi Karampetsou, Olga S Koutsoni, Georgia Gogou, Apostolis Angelis, Leandros-Alexios Skaltsounis, Eleni Dotsika
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2021
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Gata
• Online Access: https://doi.org/10.1371/journal.pntd.0008968; https://doaj.org/article/45a41f0bdc28435c9882adeab10ab02d

Background Leishmaniasis is a serious multifactorial parasitic disease with limited treatment options. Current chemotherapy is mainly consisted of drugs with serious drawbacks such as toxicity, variable efficacy and resistance. Alternative bioactive phytocompounds may provide a promising source for...