Hemophagocytic lymphohistiocytosis secondary to unrecognized Bartonella henselae infection: a case report

• Published in: Tropical Diseases, Travel Medicine and Vaccines
• Main Authors: Amanda Hempel, Fizza Manzoor, Dan Petrescu
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2023
• Subjects: Bartonella; Bartonellosis; Cat-scratch disease; Hemophagocytic lymphohistiocytosis; HLH; Immunocompetent; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1186/s40794-023-00200-1; https://doaj.org/article/458d36f0bca04d8aa03420094c83bab4

Abstract Background Bartonella henselae is a species of intracellular bacteria transmitted to humans through animal bites and scratches contaminated with the feces of arthropod vectors, and are most commonly associated with cat exposure although transmission from other mammals has been reported. Bartonella henselae infection has a spectrum of clinical manifestations and has rarely been reported as cause of hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts. Case presentation We present a report of Bartonella henselae infection progressing to HLH in an immunocompetent patient. The patient initially presented with regional lymphadenopathy but the diagnosis was not suspected as the patient reported no exposure to cats. On further history, he did report a scratch from a dog prior to development of symptoms. The patient was treated with methylprednisolone, intravenous immunoglobulin and anakinra for the HLH and three months of Doxycycline for Bartonella infection, with complete resolution of symptoms. Conclusions Although commonly associated with cat exposure, Bartonella henselae transmission can occur after exposure to other animals and vectors including dogs and clinicians need to maintain an index of suspicion for timely diagnosis. Bartonella henselae is associated with a spectrum of clinical manifestations which can include disseminated infection with severe complications such as hemophagocytic lymphohistiocytosis. Prompt initiation of Bartonella treatment is essential when thought to be the trigger for hemophagocytic lymphohistiocytosis although the optimal treatment regimen is unclear.