Assessing the impact of misclassification error on an epidemiological association between two helminthic infections.
Polyparasitism can lead to severe disability in endemic populations. Yet, the association between soil-transmitted helminth (STH) and the cumulative incidence of Schistosoma japonicum infection has not been described. The aim of this work was to quantify the effect of misclassification error, which...
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ftdoajarticles:oai:doaj.org/article:457928c057ca4613a9a253c936d36f99 2023-05-15T15:16:29+02:00 Assessing the impact of misclassification error on an epidemiological association between two helminthic infections. Mushfiqur R Tarafder Hélène Carabin Stephen T McGarvey Lawrence Joseph Ernesto Balolong Remigio Olveda 2011-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000995 https://doaj.org/article/457928c057ca4613a9a253c936d36f99 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3066162?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000995 https://doaj.org/article/457928c057ca4613a9a253c936d36f99 PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e995 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000995 2022-12-31T05:10:52Z Polyparasitism can lead to severe disability in endemic populations. Yet, the association between soil-transmitted helminth (STH) and the cumulative incidence of Schistosoma japonicum infection has not been described. The aim of this work was to quantify the effect of misclassification error, which occurs when less than 100% accurate tests are used, in STH and S. japonicum infection status on the estimation of this association.Longitudinal data from 2276 participants in 50 villages in Samar province, Philippines treated at baseline for S. japonicum infection and followed for one year, served as the basis for this analysis. Participants provided 1-3 stool samples at baseline and 12 months later (2004-2005) to detect infections with STH and S. japonicum using the Kato-Katz technique. Variation from day-to-day in the excretion of eggs in feces introduces individual variations in the sensitivity and specificity of the Kato-Katz to detect infection. Bayesian logit models were used to take this variation into account and to investigate the impact of misclassification error on the association between these infections. Uniform priors for sensitivity and specificity of the diagnostic test to detect the three STH and S. japonicum were used. All results were adjusted for age, sex, occupation, and village-level clustering. Without correction for misclassification error, the odds ratios (ORs) between hookworm, Ascaris lumbricoides, and Trichuris trichiura, and S. japonicum infections were 1.28 (95% Bayesian credible intervals: 0.93, 1.76), 0.91 (95% BCI: 0.66, 1.26), and 1.11 (95% BCI: 0.80, 1.55), respectively, and 2.13 (95% BCI: 1.16, 4.08), 0.74 (95% BCI: 0.43, 1.25), and 1.32 (95% BCI: 0.80, 2.27), respectively, after correction for misclassification error for both exposure and outcome.The misclassification bias increased with decreasing test accuracy. Hookworm infection was found to be associated with increased 12-month cumulative incidence of S. japonicum infection after correction for misclassification error. Such ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 3 e995 |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Mushfiqur R Tarafder Hélène Carabin Stephen T McGarvey Lawrence Joseph Ernesto Balolong Remigio Olveda Assessing the impact of misclassification error on an epidemiological association between two helminthic infections. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Polyparasitism can lead to severe disability in endemic populations. Yet, the association between soil-transmitted helminth (STH) and the cumulative incidence of Schistosoma japonicum infection has not been described. The aim of this work was to quantify the effect of misclassification error, which occurs when less than 100% accurate tests are used, in STH and S. japonicum infection status on the estimation of this association.Longitudinal data from 2276 participants in 50 villages in Samar province, Philippines treated at baseline for S. japonicum infection and followed for one year, served as the basis for this analysis. Participants provided 1-3 stool samples at baseline and 12 months later (2004-2005) to detect infections with STH and S. japonicum using the Kato-Katz technique. Variation from day-to-day in the excretion of eggs in feces introduces individual variations in the sensitivity and specificity of the Kato-Katz to detect infection. Bayesian logit models were used to take this variation into account and to investigate the impact of misclassification error on the association between these infections. Uniform priors for sensitivity and specificity of the diagnostic test to detect the three STH and S. japonicum were used. All results were adjusted for age, sex, occupation, and village-level clustering. Without correction for misclassification error, the odds ratios (ORs) between hookworm, Ascaris lumbricoides, and Trichuris trichiura, and S. japonicum infections were 1.28 (95% Bayesian credible intervals: 0.93, 1.76), 0.91 (95% BCI: 0.66, 1.26), and 1.11 (95% BCI: 0.80, 1.55), respectively, and 2.13 (95% BCI: 1.16, 4.08), 0.74 (95% BCI: 0.43, 1.25), and 1.32 (95% BCI: 0.80, 2.27), respectively, after correction for misclassification error for both exposure and outcome.The misclassification bias increased with decreasing test accuracy. Hookworm infection was found to be associated with increased 12-month cumulative incidence of S. japonicum infection after correction for misclassification error. Such ... |
format |
Article in Journal/Newspaper |
author |
Mushfiqur R Tarafder Hélène Carabin Stephen T McGarvey Lawrence Joseph Ernesto Balolong Remigio Olveda |
author_facet |
Mushfiqur R Tarafder Hélène Carabin Stephen T McGarvey Lawrence Joseph Ernesto Balolong Remigio Olveda |
author_sort |
Mushfiqur R Tarafder |
title |
Assessing the impact of misclassification error on an epidemiological association between two helminthic infections. |
title_short |
Assessing the impact of misclassification error on an epidemiological association between two helminthic infections. |
title_full |
Assessing the impact of misclassification error on an epidemiological association between two helminthic infections. |
title_fullStr |
Assessing the impact of misclassification error on an epidemiological association between two helminthic infections. |
title_full_unstemmed |
Assessing the impact of misclassification error on an epidemiological association between two helminthic infections. |
title_sort |
assessing the impact of misclassification error on an epidemiological association between two helminthic infections. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0000995 https://doaj.org/article/457928c057ca4613a9a253c936d36f99 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e995 (2011) |
op_relation |
http://europepmc.org/articles/PMC3066162?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000995 https://doaj.org/article/457928c057ca4613a9a253c936d36f99 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000995 |
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PLoS Neglected Tropical Diseases |
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5 |
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3 |
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e995 |
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1766346776684527616 |