Genetic Predictors of Type 2 Diabetes in Yakuts
The goal of this study was to investigate the distribution of alleles and genotypes of the KCNJ11 rs5219, PPARG rs1801282, TCF7L2 rs7903146/rs12255372 SNPs in Yakuts with T2D, in comparison with other ethnic populations. Methods and Results: The study cohort consisted of 26 Yakut patients diagnosed...
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International Medical Research and Development Corporation
2021
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ftdoajarticles:oai:doaj.org/article:456ba0290dfc4845a986cc0fcb9bc335 2023-05-15T18:45:14+02:00 Genetic Predictors of Type 2 Diabetes in Yakuts Nadezhda I. Pavlova Aleksandra T. Diakonova Vladislav A. Alekseev Lyubovy A. Sydykova Nadezhda E. Maksimova Zoya A. Rudykh Yana V. Chertovskikh Dmitry A. Sychev Vladimir V. Dodokhov Tuyara I. Dmitrieva Khariton A. Kurtanov 2021-09-01T00:00:00Z https://doi.org/10.21103/Article11(3)_OA13 https://doaj.org/article/456ba0290dfc4845a986cc0fcb9bc335 EN eng International Medical Research and Development Corporation http://ijbm.org/articles/i43/ijbm_11(3)_oa13.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article11(3)_OA13 2158-0510 2158-0529 https://doaj.org/article/456ba0290dfc4845a986cc0fcb9bc335 International Journal of Biomedicine, Vol 11, Iss 3, Pp 355-360 (2021) kcnj11 pparg tcf7l2 type 2 diabetes single nucleotide polymorphism Medicine R article 2021 ftdoajarticles https://doi.org/10.21103/Article11(3)_OA13 2022-12-31T06:43:12Z The goal of this study was to investigate the distribution of alleles and genotypes of the KCNJ11 rs5219, PPARG rs1801282, TCF7L2 rs7903146/rs12255372 SNPs in Yakuts with T2D, in comparison with other ethnic populations. Methods and Results: The study cohort consisted of 26 Yakut patients diagnosed with T2D (YKT2D). Genotyping of rs5219 (KCNJ11), rs1801282 (PPARG), rs7903146 and rs12255372 (TCF7L2) SNPs was performed by pyrosequencing using PyroMark Q48 Autoprep sequencer (QIAGEN). The genotyping of the studied group of Yakuts did not reveal statistically significant differences between control groups and YKT2D patients with respect to the polymorphic variants of the KCNJ11, PPARG, and TCF7L2 genes. The allele frequency analysis of the polymorphisms of the KCNJ11, PPARG, and TCF7L2 genes demonstrated a low frequency of the risk T-allele in the TCF7L2 (rs7903146, rs12255372) in Asian populations, compared to other human populations. We identified three haplotypes [CG (90.5%), TT (6.8%), and TG (2.7%)] in the YKT2D cohort. Also, we observed a strong LD between two SNPs (rs7903146 and rs12255372) of the TCF7L2 gene in the majority of groups, including YKT2D (D '= 1, LOD = 4.92), except for African populations, where a very weak LD (D '= 0.001-0.435, LOD = 0.0-0.73) was observed. Article in Journal/Newspaper Yakuts Directory of Open Access Journals: DOAJ Articles International Journal of Biomedicine 11 3 355 360 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
kcnj11 pparg tcf7l2 type 2 diabetes single nucleotide polymorphism Medicine R |
spellingShingle |
kcnj11 pparg tcf7l2 type 2 diabetes single nucleotide polymorphism Medicine R Nadezhda I. Pavlova Aleksandra T. Diakonova Vladislav A. Alekseev Lyubovy A. Sydykova Nadezhda E. Maksimova Zoya A. Rudykh Yana V. Chertovskikh Dmitry A. Sychev Vladimir V. Dodokhov Tuyara I. Dmitrieva Khariton A. Kurtanov Genetic Predictors of Type 2 Diabetes in Yakuts |
topic_facet |
kcnj11 pparg tcf7l2 type 2 diabetes single nucleotide polymorphism Medicine R |
description |
The goal of this study was to investigate the distribution of alleles and genotypes of the KCNJ11 rs5219, PPARG rs1801282, TCF7L2 rs7903146/rs12255372 SNPs in Yakuts with T2D, in comparison with other ethnic populations. Methods and Results: The study cohort consisted of 26 Yakut patients diagnosed with T2D (YKT2D). Genotyping of rs5219 (KCNJ11), rs1801282 (PPARG), rs7903146 and rs12255372 (TCF7L2) SNPs was performed by pyrosequencing using PyroMark Q48 Autoprep sequencer (QIAGEN). The genotyping of the studied group of Yakuts did not reveal statistically significant differences between control groups and YKT2D patients with respect to the polymorphic variants of the KCNJ11, PPARG, and TCF7L2 genes. The allele frequency analysis of the polymorphisms of the KCNJ11, PPARG, and TCF7L2 genes demonstrated a low frequency of the risk T-allele in the TCF7L2 (rs7903146, rs12255372) in Asian populations, compared to other human populations. We identified three haplotypes [CG (90.5%), TT (6.8%), and TG (2.7%)] in the YKT2D cohort. Also, we observed a strong LD between two SNPs (rs7903146 and rs12255372) of the TCF7L2 gene in the majority of groups, including YKT2D (D '= 1, LOD = 4.92), except for African populations, where a very weak LD (D '= 0.001-0.435, LOD = 0.0-0.73) was observed. |
format |
Article in Journal/Newspaper |
author |
Nadezhda I. Pavlova Aleksandra T. Diakonova Vladislav A. Alekseev Lyubovy A. Sydykova Nadezhda E. Maksimova Zoya A. Rudykh Yana V. Chertovskikh Dmitry A. Sychev Vladimir V. Dodokhov Tuyara I. Dmitrieva Khariton A. Kurtanov |
author_facet |
Nadezhda I. Pavlova Aleksandra T. Diakonova Vladislav A. Alekseev Lyubovy A. Sydykova Nadezhda E. Maksimova Zoya A. Rudykh Yana V. Chertovskikh Dmitry A. Sychev Vladimir V. Dodokhov Tuyara I. Dmitrieva Khariton A. Kurtanov |
author_sort |
Nadezhda I. Pavlova |
title |
Genetic Predictors of Type 2 Diabetes in Yakuts |
title_short |
Genetic Predictors of Type 2 Diabetes in Yakuts |
title_full |
Genetic Predictors of Type 2 Diabetes in Yakuts |
title_fullStr |
Genetic Predictors of Type 2 Diabetes in Yakuts |
title_full_unstemmed |
Genetic Predictors of Type 2 Diabetes in Yakuts |
title_sort |
genetic predictors of type 2 diabetes in yakuts |
publisher |
International Medical Research and Development Corporation |
publishDate |
2021 |
url |
https://doi.org/10.21103/Article11(3)_OA13 https://doaj.org/article/456ba0290dfc4845a986cc0fcb9bc335 |
genre |
Yakuts |
genre_facet |
Yakuts |
op_source |
International Journal of Biomedicine, Vol 11, Iss 3, Pp 355-360 (2021) |
op_relation |
http://ijbm.org/articles/i43/ijbm_11(3)_oa13.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article11(3)_OA13 2158-0510 2158-0529 https://doaj.org/article/456ba0290dfc4845a986cc0fcb9bc335 |
op_doi |
https://doi.org/10.21103/Article11(3)_OA13 |
container_title |
International Journal of Biomedicine |
container_volume |
11 |
container_issue |
3 |
container_start_page |
355 |
op_container_end_page |
360 |
_version_ |
1766236272944218112 |