Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies.
Background Leptospirosis is a worldwide prevalent zoonosis and chronic kidney disease (CKD) is a leading global disease burden. Because of pathophysiological changes in the kidney, it has been suggested that these conditions may be associated. However, the extent of this interaction has not been syn...
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ftdoajarticles:oai:doaj.org/article:4508040d9907460aa28ec81cc6801b9a 2023-05-15T15:12:21+02:00 Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies. Rodrigo M Carrillo-Larco Carlos Altez-Fernandez J Gonzalo Acevedo-Rodriguez Karol Ortiz-Acha Cesar Ugarte-Gil 2019-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007458 https://doaj.org/article/4508040d9907460aa28ec81cc6801b9a EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007458 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007458 https://doaj.org/article/4508040d9907460aa28ec81cc6801b9a PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007458 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007458 2022-12-31T05:51:59Z Background Leptospirosis is a worldwide prevalent zoonosis and chronic kidney disease (CKD) is a leading global disease burden. Because of pathophysiological changes in the kidney, it has been suggested that these conditions may be associated. However, the extent of this interaction has not been synthetized. We aimed to systematically review and critically appraise the evidence on the association between leptospirosis and CKD. Methodology/principal findings Observational studies with a control group were selected. Leptospirosis, confirmed with laboratory methods, and CKD also based on a laboratory assessment, were the exposures and outcomes of interest. The search was conducted in EMBASE, MEDLINE, Global Health, Scopus and Web of Science. Studies selected for qualitative synthesis were assessed for risk of bias following the Newcastle-Ottawa Scale. 5,981 reports were screened, and 2 (n = 3,534) were included for qualitative synthesis. The studies were conducted in Taiwan and Nicaragua; these reported cross-sectional and longitudinal estimates. In the general population, the mean estimated glomerular filtration rate (eGFR) was lower (p<0.001) in people testing positive for antileptospira antibodies (eGFR = 98.3) than in negative controls (eGFR = 100.8). Among sugarcane applicants with high creatinine, those who were seropositive had lower eGFR (mean difference: -10.08). In a prospective analysis, people with high antileptospira antibodies titer at baseline and follow-up, had worse eGFR (p<0.05). Conclusion Although the available evidence suggests there may be a positive association between leptospirosis and CKD, whereby leptospirosis could be a risk factor for CKD, it is still premature to draw conclusions. There is an urgent need for research on this association. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 5 e0007458 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rodrigo M Carrillo-Larco Carlos Altez-Fernandez J Gonzalo Acevedo-Rodriguez Karol Ortiz-Acha Cesar Ugarte-Gil Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Leptospirosis is a worldwide prevalent zoonosis and chronic kidney disease (CKD) is a leading global disease burden. Because of pathophysiological changes in the kidney, it has been suggested that these conditions may be associated. However, the extent of this interaction has not been synthetized. We aimed to systematically review and critically appraise the evidence on the association between leptospirosis and CKD. Methodology/principal findings Observational studies with a control group were selected. Leptospirosis, confirmed with laboratory methods, and CKD also based on a laboratory assessment, were the exposures and outcomes of interest. The search was conducted in EMBASE, MEDLINE, Global Health, Scopus and Web of Science. Studies selected for qualitative synthesis were assessed for risk of bias following the Newcastle-Ottawa Scale. 5,981 reports were screened, and 2 (n = 3,534) were included for qualitative synthesis. The studies were conducted in Taiwan and Nicaragua; these reported cross-sectional and longitudinal estimates. In the general population, the mean estimated glomerular filtration rate (eGFR) was lower (p<0.001) in people testing positive for antileptospira antibodies (eGFR = 98.3) than in negative controls (eGFR = 100.8). Among sugarcane applicants with high creatinine, those who were seropositive had lower eGFR (mean difference: -10.08). In a prospective analysis, people with high antileptospira antibodies titer at baseline and follow-up, had worse eGFR (p<0.05). Conclusion Although the available evidence suggests there may be a positive association between leptospirosis and CKD, whereby leptospirosis could be a risk factor for CKD, it is still premature to draw conclusions. There is an urgent need for research on this association. |
format |
Article in Journal/Newspaper |
author |
Rodrigo M Carrillo-Larco Carlos Altez-Fernandez J Gonzalo Acevedo-Rodriguez Karol Ortiz-Acha Cesar Ugarte-Gil |
author_facet |
Rodrigo M Carrillo-Larco Carlos Altez-Fernandez J Gonzalo Acevedo-Rodriguez Karol Ortiz-Acha Cesar Ugarte-Gil |
author_sort |
Rodrigo M Carrillo-Larco |
title |
Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies. |
title_short |
Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies. |
title_full |
Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies. |
title_fullStr |
Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies. |
title_full_unstemmed |
Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies. |
title_sort |
leptospirosis as a risk factor for chronic kidney disease: a systematic review of observational studies. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007458 https://doaj.org/article/4508040d9907460aa28ec81cc6801b9a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007458 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007458 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007458 https://doaj.org/article/4508040d9907460aa28ec81cc6801b9a |
op_doi |
https://doi.org/10.1371/journal.pntd.0007458 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
5 |
container_start_page |
e0007458 |
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1766343044897964032 |