FEATURES OF CYTOKINE PRODUCTION IN PATIENTS WITH UNSTABLE ANGINA: DEPENDENCE ON ETHNICITY IN THE REPUBLIC OF SAKHA (YAKUTIA)

• Published in: Medical Immunology (Russia)
• Main Authors: A. S. Golderova, I. N. Nikolaeva, V. E. Tarasova, V. A. Kozlov
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014
• Subjects: cytokines; atherosclerosis; unstable angina; Immunologic diseases. Allergy; RC581-607; Republic of Sakha; Yakutia; Yakuts
• Online Access: https://doi.org/10.15789/1563-0625-2012-1-2-143-148; https://doaj.org/article/44bec16f60a5462ba4325cc8ccfde48e

Abstract. We investigated levels of spontaneous and mitogen-induced cytokine production (IL-1β, IL-4, IL-6, IL-10 and IFNγ) by peripheral blood cells of 24 men with unstable angina (UA), including indigenous population (n = 12, Yakuts), and a group of Russian migrants to the Republic of Sakha (n = 12). Activation of inflammatory response was revealed in the total group of patients with UA, manifesting by increase of spontaneous and induced production of the pro-inflammatory IL-1β, IL-6 cytokines, and mitogen-induced production of IFNγ. As compared with healthy individuals, spontaneous and induced production of anti-inflammatory IL-4 was decreased in UA patients, whereas the mitogen-induced production of IL-10 proved to be enhanced. Therefore, it is highly possible that a pro-atherogenic Th1-immune response is developing during UA, along with suppression of Th2-driving response. The differences revealed for different ethnic groups suggest that severity and prevalence of atherosclerotic disease, which is more common in the non-native patients, is associated with increased production of pro-inflammatory IL-1β and IL-6 cytokines.