Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission.
Plasmodium vivax transmission in Thailand has been substantially reduced over the past 10 years, yet it remains highly endemic along international borders. Understanding the genetic relationship of residual parasite populations can help track the origins of the parasites that are reintroduced into m...
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ftdoajarticles:oai:doaj.org/article:449fce3a26294e92a560935542071340 2023-05-15T15:07:33+02:00 Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission. Veerayuth Kittichai Cristian Koepfli Wang Nguitragool Jetsumon Sattabongkot Liwang Cui 2017-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005930 https://doaj.org/article/449fce3a26294e92a560935542071340 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5658191?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005930 https://doaj.org/article/449fce3a26294e92a560935542071340 PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005930 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005930 2022-12-31T03:00:00Z Plasmodium vivax transmission in Thailand has been substantially reduced over the past 10 years, yet it remains highly endemic along international borders. Understanding the genetic relationship of residual parasite populations can help track the origins of the parasites that are reintroduced into malaria-free regions within the country.A total of 127 P. vivax isolates were genotyped from two western provinces (Tak and Kanchanaburi) and one eastern province (Ubon Ratchathani) of Thailand using 10 microsatellite markers. Genetic diversity was high, but recent clonal expansion was detected in all three provinces. Substantial population structure and genetic differentiation of parasites among provinces suggest limited gene flow among these sites. There was no haplotype sharing among the three sites, and a reduced panel of four microsatellite markers was sufficient to assign the parasites to their provincial origins.Significant parasite genetic differentiation between provinces shows successful interruption of parasite spread within Thailand, but high diversity along international borders implies a substantial parasite population size in these regions. The provincial origin of P. vivax cases can be reliably determined by genotyping four microsatellite markers, which should be useful for monitoring parasite reintroduction after malaria elimination. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 10 e0005930 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Veerayuth Kittichai Cristian Koepfli Wang Nguitragool Jetsumon Sattabongkot Liwang Cui Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Plasmodium vivax transmission in Thailand has been substantially reduced over the past 10 years, yet it remains highly endemic along international borders. Understanding the genetic relationship of residual parasite populations can help track the origins of the parasites that are reintroduced into malaria-free regions within the country.A total of 127 P. vivax isolates were genotyped from two western provinces (Tak and Kanchanaburi) and one eastern province (Ubon Ratchathani) of Thailand using 10 microsatellite markers. Genetic diversity was high, but recent clonal expansion was detected in all three provinces. Substantial population structure and genetic differentiation of parasites among provinces suggest limited gene flow among these sites. There was no haplotype sharing among the three sites, and a reduced panel of four microsatellite markers was sufficient to assign the parasites to their provincial origins.Significant parasite genetic differentiation between provinces shows successful interruption of parasite spread within Thailand, but high diversity along international borders implies a substantial parasite population size in these regions. The provincial origin of P. vivax cases can be reliably determined by genotyping four microsatellite markers, which should be useful for monitoring parasite reintroduction after malaria elimination. |
format |
Article in Journal/Newspaper |
author |
Veerayuth Kittichai Cristian Koepfli Wang Nguitragool Jetsumon Sattabongkot Liwang Cui |
author_facet |
Veerayuth Kittichai Cristian Koepfli Wang Nguitragool Jetsumon Sattabongkot Liwang Cui |
author_sort |
Veerayuth Kittichai |
title |
Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission. |
title_short |
Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission. |
title_full |
Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission. |
title_fullStr |
Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission. |
title_full_unstemmed |
Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission. |
title_sort |
substantial population structure of plasmodium vivax in thailand facilitates identification of the sources of residual transmission. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005930 https://doaj.org/article/449fce3a26294e92a560935542071340 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005930 (2017) |
op_relation |
http://europepmc.org/articles/PMC5658191?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005930 https://doaj.org/article/449fce3a26294e92a560935542071340 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005930 |
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PLOS Neglected Tropical Diseases |
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11 |
container_issue |
10 |
container_start_page |
e0005930 |
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1766339037526753280 |