The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression
IntroductionApproximately one-third of adults with chronic pain also report clinically relevant levels of depression. Internet-delivered psychological therapies such as Cognitive Behavioural Therapy (iCBT) and Acceptance and Commitment Therapy (iACT) have been developed to overcome barriers of acces...
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ftdoajarticles:oai:doaj.org/article:448fe78e70ec4f06b7ff3e3fbaed8d41 2023-05-15T17:22:45+02:00 The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression Louise V Bell Peter Cornish David Flusk Sheila N Garland Joshua A Rash 2020-02-01T00:00:00Z https://doi.org/10.1136/bmjopen-2019-033350 https://doaj.org/article/448fe78e70ec4f06b7ff3e3fbaed8d41 EN eng BMJ Publishing Group https://bmjopen.bmj.com/content/10/2/e033350.full https://doaj.org/toc/2044-6055 doi:10.1136/bmjopen-2019-033350 2044-6055 https://doaj.org/article/448fe78e70ec4f06b7ff3e3fbaed8d41 BMJ Open, Vol 10, Iss 2 (2020) Medicine R article 2020 ftdoajarticles https://doi.org/10.1136/bmjopen-2019-033350 2022-12-31T13:19:51Z IntroductionApproximately one-third of adults with chronic pain also report clinically relevant levels of depression. Internet-delivered psychological therapies such as Cognitive Behavioural Therapy (iCBT) and Acceptance and Commitment Therapy (iACT) have been developed to overcome barriers of access to services and ensure the timely delivery of care. The objective of this trial is to collect data on feasibility, acceptability and range of probable effect sizes for iCBT and iACT interventions tailored towards the treatment of depression and chronic pain using a randomised controlled patient-preference design.Methods and analysisCommunity dwelling adults with chronic non-cancer pain (CNCP) and major depression will be recruited from pain clinics and primary care providers in Newfoundland and Labrador, Canada. The study is a randomised controlled patient-preference trial. Eligible patients will be randomly assigned to a ‘preference’ or ‘no-preference’ arm during the first step of randomisation and to intervention or control in the second step of randomisation. Two interventions (ie, iCBT or iACT) will be evaluated relative to attention control. iCBT and iACT involve the completion of 7-weekly online modules augmented with one session of motivational enhancement and weekly therapy sessions. Primary outcomes include (1) feasibility and acceptability parameters and (2) change in symptoms of depression. Secondary outcomes include pain, physical function, emotional function and quality of life. We will recruit 60 participants and examine the range of effect sizes obtained from the trial but will not conduct significance testing as per recommendations for behavioural trial development.Ethics and disseminationEthics was approved by the provincial Health Research Ethics Board. Dissemination of results will be published in a peer-reviewed academic journal and presented at scientific conferences.Trial registration numberNCT04009135. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Newfoundland Canada BMJ Open 10 2 e033350 |
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Medicine R Louise V Bell Peter Cornish David Flusk Sheila N Garland Joshua A Rash The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression |
topic_facet |
Medicine R |
description |
IntroductionApproximately one-third of adults with chronic pain also report clinically relevant levels of depression. Internet-delivered psychological therapies such as Cognitive Behavioural Therapy (iCBT) and Acceptance and Commitment Therapy (iACT) have been developed to overcome barriers of access to services and ensure the timely delivery of care. The objective of this trial is to collect data on feasibility, acceptability and range of probable effect sizes for iCBT and iACT interventions tailored towards the treatment of depression and chronic pain using a randomised controlled patient-preference design.Methods and analysisCommunity dwelling adults with chronic non-cancer pain (CNCP) and major depression will be recruited from pain clinics and primary care providers in Newfoundland and Labrador, Canada. The study is a randomised controlled patient-preference trial. Eligible patients will be randomly assigned to a ‘preference’ or ‘no-preference’ arm during the first step of randomisation and to intervention or control in the second step of randomisation. Two interventions (ie, iCBT or iACT) will be evaluated relative to attention control. iCBT and iACT involve the completion of 7-weekly online modules augmented with one session of motivational enhancement and weekly therapy sessions. Primary outcomes include (1) feasibility and acceptability parameters and (2) change in symptoms of depression. Secondary outcomes include pain, physical function, emotional function and quality of life. We will recruit 60 participants and examine the range of effect sizes obtained from the trial but will not conduct significance testing as per recommendations for behavioural trial development.Ethics and disseminationEthics was approved by the provincial Health Research Ethics Board. Dissemination of results will be published in a peer-reviewed academic journal and presented at scientific conferences.Trial registration numberNCT04009135. |
format |
Article in Journal/Newspaper |
author |
Louise V Bell Peter Cornish David Flusk Sheila N Garland Joshua A Rash |
author_facet |
Louise V Bell Peter Cornish David Flusk Sheila N Garland Joshua A Rash |
author_sort |
Louise V Bell |
title |
The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression |
title_short |
The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression |
title_full |
The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression |
title_fullStr |
The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression |
title_full_unstemmed |
The INternet ThERapy for deprESsion Trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression |
title_sort |
internet therapy for depression trial (interest): protocol for a patient-preference, randomised controlled feasibility trial comparing iact, icbt and attention control among individuals with comorbid chronic pain and depression |
publisher |
BMJ Publishing Group |
publishDate |
2020 |
url |
https://doi.org/10.1136/bmjopen-2019-033350 https://doaj.org/article/448fe78e70ec4f06b7ff3e3fbaed8d41 |
geographic |
Newfoundland Canada |
geographic_facet |
Newfoundland Canada |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
BMJ Open, Vol 10, Iss 2 (2020) |
op_relation |
https://bmjopen.bmj.com/content/10/2/e033350.full https://doaj.org/toc/2044-6055 doi:10.1136/bmjopen-2019-033350 2044-6055 https://doaj.org/article/448fe78e70ec4f06b7ff3e3fbaed8d41 |
op_doi |
https://doi.org/10.1136/bmjopen-2019-033350 |
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BMJ Open |
container_volume |
10 |
container_issue |
2 |
container_start_page |
e033350 |
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1766109592606998528 |