Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil
Dengue infection (DI) transmitted by arthropod vectors is the viral disease with the highest incidence throughout the world, an estimated 300 million cases per year. In addition to environmental factors, genetic factors may also influence the manifestation of the disease; as even in endemic areas, o...
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ftdoajarticles:oai:doaj.org/article:445c301f00824239afdbabd4c730281f 2023-05-15T15:05:03+02:00 Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil Daniela Maria Cardozo Ricardo Alberto Moliterno Ana Maria Sell Gláucia Andréia Soares Guelsin Leticia Maria Beltrame Samaia Laface Clementino Pamela Guimarães Reis Hugo Vicentin Alves Priscila Saamara Mazini Jeane Eliete Laguila Visentainer 2014-01-01T00:00:00Z https://doi.org/10.1155/2014/968262 https://doaj.org/article/445c301f00824239afdbabd4c730281f EN eng Hindawi Limited http://dx.doi.org/10.1155/2014/968262 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2014/968262 https://doaj.org/article/445c301f00824239afdbabd4c730281f Journal of Tropical Medicine, Vol 2014 (2014) Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.1155/2014/968262 2022-12-31T14:27:56Z Dengue infection (DI) transmitted by arthropod vectors is the viral disease with the highest incidence throughout the world, an estimated 300 million cases per year. In addition to environmental factors, genetic factors may also influence the manifestation of the disease; as even in endemic areas, only a small proportion of people develop the most serious form. Immune-response gene polymorphisms may be associated with the development of cases of DI. The aim of this study was to determine allele frequencies in the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in a Southern Brazil population with dengue virus serotype 3, confirmed by the ELISA serological method, and a control group. The identification of the HLA alleles was carried out using the SSO genotyping PCR program (One Lambda), based on Luminex technology. In conclusion, this study suggests that DQB1*06:11 allele could act as susceptible factors to dengue virus serotype 3, while HLA-DRB1*11 and DQA1*05:01 could act as resistance factors. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Lambda ENVELOPE(-62.983,-62.983,-64.300,-64.300) Journal of Tropical Medicine 2014 1 6 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Daniela Maria Cardozo Ricardo Alberto Moliterno Ana Maria Sell Gláucia Andréia Soares Guelsin Leticia Maria Beltrame Samaia Laface Clementino Pamela Guimarães Reis Hugo Vicentin Alves Priscila Saamara Mazini Jeane Eliete Laguila Visentainer Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Dengue infection (DI) transmitted by arthropod vectors is the viral disease with the highest incidence throughout the world, an estimated 300 million cases per year. In addition to environmental factors, genetic factors may also influence the manifestation of the disease; as even in endemic areas, only a small proportion of people develop the most serious form. Immune-response gene polymorphisms may be associated with the development of cases of DI. The aim of this study was to determine allele frequencies in the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in a Southern Brazil population with dengue virus serotype 3, confirmed by the ELISA serological method, and a control group. The identification of the HLA alleles was carried out using the SSO genotyping PCR program (One Lambda), based on Luminex technology. In conclusion, this study suggests that DQB1*06:11 allele could act as susceptible factors to dengue virus serotype 3, while HLA-DRB1*11 and DQA1*05:01 could act as resistance factors. |
format |
Article in Journal/Newspaper |
author |
Daniela Maria Cardozo Ricardo Alberto Moliterno Ana Maria Sell Gláucia Andréia Soares Guelsin Leticia Maria Beltrame Samaia Laface Clementino Pamela Guimarães Reis Hugo Vicentin Alves Priscila Saamara Mazini Jeane Eliete Laguila Visentainer |
author_facet |
Daniela Maria Cardozo Ricardo Alberto Moliterno Ana Maria Sell Gláucia Andréia Soares Guelsin Leticia Maria Beltrame Samaia Laface Clementino Pamela Guimarães Reis Hugo Vicentin Alves Priscila Saamara Mazini Jeane Eliete Laguila Visentainer |
author_sort |
Daniela Maria Cardozo |
title |
Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil |
title_short |
Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil |
title_full |
Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil |
title_fullStr |
Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil |
title_full_unstemmed |
Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil |
title_sort |
evidence of hla-dqb1 contribution to susceptibility of dengue serotype 3 in dengue patients in southern brazil |
publisher |
Hindawi Limited |
publishDate |
2014 |
url |
https://doi.org/10.1155/2014/968262 https://doaj.org/article/445c301f00824239afdbabd4c730281f |
long_lat |
ENVELOPE(-62.983,-62.983,-64.300,-64.300) |
geographic |
Arctic Lambda |
geographic_facet |
Arctic Lambda |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2014 (2014) |
op_relation |
http://dx.doi.org/10.1155/2014/968262 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2014/968262 https://doaj.org/article/445c301f00824239afdbabd4c730281f |
op_doi |
https://doi.org/10.1155/2014/968262 |
container_title |
Journal of Tropical Medicine |
container_volume |
2014 |
container_start_page |
1 |
op_container_end_page |
6 |
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1766336807893467136 |