Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil

Dengue infection (DI) transmitted by arthropod vectors is the viral disease with the highest incidence throughout the world, an estimated 300 million cases per year. In addition to environmental factors, genetic factors may also influence the manifestation of the disease; as even in endemic areas, o...

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Published in:Journal of Tropical Medicine
Main Authors: Daniela Maria Cardozo, Ricardo Alberto Moliterno, Ana Maria Sell, Gláucia Andréia Soares Guelsin, Leticia Maria Beltrame, Samaia Laface Clementino, Pamela Guimarães Reis, Hugo Vicentin Alves, Priscila Saamara Mazini, Jeane Eliete Laguila Visentainer
Format: Article in Journal/Newspaper
Language:English
Published: Hindawi Limited 2014
Subjects:
Online Access:https://doi.org/10.1155/2014/968262
https://doaj.org/article/445c301f00824239afdbabd4c730281f
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spelling ftdoajarticles:oai:doaj.org/article:445c301f00824239afdbabd4c730281f 2023-05-15T15:05:03+02:00 Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil Daniela Maria Cardozo Ricardo Alberto Moliterno Ana Maria Sell Gláucia Andréia Soares Guelsin Leticia Maria Beltrame Samaia Laface Clementino Pamela Guimarães Reis Hugo Vicentin Alves Priscila Saamara Mazini Jeane Eliete Laguila Visentainer 2014-01-01T00:00:00Z https://doi.org/10.1155/2014/968262 https://doaj.org/article/445c301f00824239afdbabd4c730281f EN eng Hindawi Limited http://dx.doi.org/10.1155/2014/968262 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2014/968262 https://doaj.org/article/445c301f00824239afdbabd4c730281f Journal of Tropical Medicine, Vol 2014 (2014) Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.1155/2014/968262 2022-12-31T14:27:56Z Dengue infection (DI) transmitted by arthropod vectors is the viral disease with the highest incidence throughout the world, an estimated 300 million cases per year. In addition to environmental factors, genetic factors may also influence the manifestation of the disease; as even in endemic areas, only a small proportion of people develop the most serious form. Immune-response gene polymorphisms may be associated with the development of cases of DI. The aim of this study was to determine allele frequencies in the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in a Southern Brazil population with dengue virus serotype 3, confirmed by the ELISA serological method, and a control group. The identification of the HLA alleles was carried out using the SSO genotyping PCR program (One Lambda), based on Luminex technology. In conclusion, this study suggests that DQB1*06:11 allele could act as susceptible factors to dengue virus serotype 3, while HLA-DRB1*11 and DQA1*05:01 could act as resistance factors. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Lambda ENVELOPE(-62.983,-62.983,-64.300,-64.300) Journal of Tropical Medicine 2014 1 6
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Arctic medicine. Tropical medicine
RC955-962
spellingShingle Arctic medicine. Tropical medicine
RC955-962
Daniela Maria Cardozo
Ricardo Alberto Moliterno
Ana Maria Sell
Gláucia Andréia Soares Guelsin
Leticia Maria Beltrame
Samaia Laface Clementino
Pamela Guimarães Reis
Hugo Vicentin Alves
Priscila Saamara Mazini
Jeane Eliete Laguila Visentainer
Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil
topic_facet Arctic medicine. Tropical medicine
RC955-962
description Dengue infection (DI) transmitted by arthropod vectors is the viral disease with the highest incidence throughout the world, an estimated 300 million cases per year. In addition to environmental factors, genetic factors may also influence the manifestation of the disease; as even in endemic areas, only a small proportion of people develop the most serious form. Immune-response gene polymorphisms may be associated with the development of cases of DI. The aim of this study was to determine allele frequencies in the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in a Southern Brazil population with dengue virus serotype 3, confirmed by the ELISA serological method, and a control group. The identification of the HLA alleles was carried out using the SSO genotyping PCR program (One Lambda), based on Luminex technology. In conclusion, this study suggests that DQB1*06:11 allele could act as susceptible factors to dengue virus serotype 3, while HLA-DRB1*11 and DQA1*05:01 could act as resistance factors.
format Article in Journal/Newspaper
author Daniela Maria Cardozo
Ricardo Alberto Moliterno
Ana Maria Sell
Gláucia Andréia Soares Guelsin
Leticia Maria Beltrame
Samaia Laface Clementino
Pamela Guimarães Reis
Hugo Vicentin Alves
Priscila Saamara Mazini
Jeane Eliete Laguila Visentainer
author_facet Daniela Maria Cardozo
Ricardo Alberto Moliterno
Ana Maria Sell
Gláucia Andréia Soares Guelsin
Leticia Maria Beltrame
Samaia Laface Clementino
Pamela Guimarães Reis
Hugo Vicentin Alves
Priscila Saamara Mazini
Jeane Eliete Laguila Visentainer
author_sort Daniela Maria Cardozo
title Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil
title_short Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil
title_full Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil
title_fullStr Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil
title_full_unstemmed Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil
title_sort evidence of hla-dqb1 contribution to susceptibility of dengue serotype 3 in dengue patients in southern brazil
publisher Hindawi Limited
publishDate 2014
url https://doi.org/10.1155/2014/968262
https://doaj.org/article/445c301f00824239afdbabd4c730281f
long_lat ENVELOPE(-62.983,-62.983,-64.300,-64.300)
geographic Arctic
Lambda
geographic_facet Arctic
Lambda
genre Arctic
genre_facet Arctic
op_source Journal of Tropical Medicine, Vol 2014 (2014)
op_relation http://dx.doi.org/10.1155/2014/968262
https://doaj.org/toc/1687-9686
https://doaj.org/toc/1687-9694
1687-9686
1687-9694
doi:10.1155/2014/968262
https://doaj.org/article/445c301f00824239afdbabd4c730281f
op_doi https://doi.org/10.1155/2014/968262
container_title Journal of Tropical Medicine
container_volume 2014
container_start_page 1
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