Drug susceptibility of M. tuberculosis in tuberculosis patients from various population groups in Khanty-Mansiyskiy Autonomous Region

• Main Authors: Yu. V. Reshetnikova, S. N. Аndreevskaya, E. E. Larionova
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: New Terra Publishing House 2015
• Subjects: туберкулез; множественная лекарственная устойчивость; широкая лекарственная устойчивость; Diseases of the respiratory system; RC705-779; khanty
• Online Access: https://doaj.org/article/4443c1ae23c549f794a0e9db05756f10

The study included 287 cultures of tuberculous mycobacteria received from specimens of patients from Khanty-Mansiysky TB Dispensary in 2011-2012. Patients from Khanty-Mansiysky TB Dispensary have a fairly high rate (24.0%) of co-infection of TB and HIV, especially among urban population (26.8%) compared to rural (13.6%) citizens. When analyzing the drug susceptibility of tuberculous mycobacteria isolated from pulmonary tuberculosis patients it has been found out that multiple drug resistant strains prevailed in the regions (56.8% of all drug resistant strains), and among them in more than a half of cases the strains were resistant not only to HR but to 3-4 additional TB drugs (29.3% of the total number of tested strains), which significantly increases the risk of treatment failure.