Schistosoma mansoni: acquired immunity in mice after the use of oxamniquine at the evolutive skin and pulmonary phases Schistosoma mansoni: imunidade adquirida em camundongos, após o uso de oxamniquina durante as fases evolutivas da pele e do pulmão

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Paulo Marcos Z. Coelho, Rômulo T. Mello, Sílvia E. Gerken
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1991
• Subjects: Schistosoma mansoni; Acquired immunity; Oxamniquine; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46651991000100006; https://doaj.org/article/443110bdc60241b9bd9d38f09964e536

Mice infected with 350 cercariae of Schistosoma mansoni (LE strain) were treated with oxamniquine, at the dose of 400 mg/kg, 24, 48, 72, and 96 h after infection. Forty days after the treatment, the animals were submitted to a challenge infection with 80 cercariae, through the abdominal and ear skins. The number of immature worms in the animal groups treated 24 and 96 h after the first infection was found to be lower than that in the control group, thus showing that the death of schisto-somes by chemotherapy, at the skin and pulmonary phases, causes an acquired resistance state. Camundongos infectados com 350 cercárias de Schistosoma mansoni (cepa LE) foram tratados com oxamniquina, em dose única de 400 mg/kg, 24,48,72 e 96 horas após a infecção. Quarenta dias após o tratamento, os animais foram submetidos a uma infecção desafio com 80 cercárias, através da pele abdominal e da orelha. O número de vermes imaturos nos grupos de animais tratados 24 e 96 horas após a primeira infecção foi menor do que o do grupo controle, evidenciando que a morte de esquistossômulos por quimioterapia, durante as fases da pele e do pulmão, causa um estado de resistência adquirida.