Tratamento da giardiase com tinidazol

• Main Authors: Miroslau Constante Baranski, Milton Carneiro Filho, Luiz Alberto Cagliari Santos, Cláudio José Trezub
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1975
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Arctic; Droga
• Online Access: https://doaj.org/article/4428c9805c7a48d2b1f30f4e1809a673

Estudou-se a eficácia terapêutica do tinidazol, um novo derivado nitroimidazólico, em trinta pacientes com giardiase. A posologia diária foi de 300 mg em 20 pacientes com idade superior a 10 anos, e de 150 mg em 10 crianças com idade inferior a 10 anos. O tratamento teve a duração de cinco dias. O diagnóstico e os controles de cura parasitológicos foram feitos pelos métodos de Hoffman, Pons & Janer e de Faust e cols. Foram realizados três controles, com intervalos de sete dias, iniciando-se na semana subsequente ao término do tratamento. Obtiveram cura parasitológica em 96,6% dos casos. Ressaltam a excelente tolerância da droga, mesmo em pacientes com grave doença fundamental ou em crianças, não se registrando efeitos colaterais. Concluem ser o tinidazol excelente droga giardicida. The Autors study the therapeutic efficacy of Tinidazole, a new nitrimidazole derivative, in the treatment of thirty patients with giardiasis. They employed the daily dosage of 300 mg for twenty patients and 150 mg for ten children, respectively with ten years of age or and less during five consecutive days. The diagnosis and the parasitological evaluation of the results of treatment were accomplished by stool examinations using zinc sulphate centrifugal-flotation technique of Faust et al. and sedimentatian-concentration technique of Hoffman, Pons and Janer. The control started one week after the treatment and consisted of three stool examinations, at one week intervals. The Authors achieved 96.6 per cent of parasitological cures. They stressed the excellent tolerance of the drug ,even by patients with serious fundamental diseases or by children. No side effects were registered. They conclude that Tinidazole is an excellent drug against Giardia lamblia infections.