Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities
Background Histoplasmosis is a chronic granulomatous disease caused by the thermally dimorphic fungus Histoplasma capsulatum. The 2 variants Histoplasma capsulatum var. capsulatum (Hcc) and Histoplasma capsulatum var. duboisii (Hcd) causes infection in humans and commonly termed classical or America...
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ftdoajarticles:oai:doaj.org/article:43b944ae32e7481ea1800b7d0fb32c87 2023-05-15T15:11:42+02:00 Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities Bright K. Ocansey Chris Kosmidis Martin Agyei Améyo M. Dorkenoo Olusola O. Ayanlowo Rita O. Oladele Tchin Darre David W. Denning 2022-02-01T00:00:00Z https://doaj.org/article/43b944ae32e7481ea1800b7d0fb32c87 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870498/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/43b944ae32e7481ea1800b7d0fb32c87 PLoS Neglected Tropical Diseases, Vol 16, Iss 2 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles 2022-12-31T07:30:12Z Background Histoplasmosis is a chronic granulomatous disease caused by the thermally dimorphic fungus Histoplasma capsulatum. The 2 variants Histoplasma capsulatum var. capsulatum (Hcc) and Histoplasma capsulatum var. duboisii (Hcd) causes infection in humans and commonly termed classical or American histoplasmosis and African histoplasmosis, respectively. Histoplasma capsulatum var. farciminosum (Hcf) affects equines. In recent times, there have been heightened sensitization on fungal infections such as histoplasmosis in Africa, aimed at improving awareness among relevant stakeholders, particularly healthcare workers. This effort is expected to be paralleled with increased detection of both classical and African histoplasmosis, which has remained underdiagnosed over the years. In this narrative review, we describe the current perspectives of histoplasmosis in Africa, identify knowledge gaps, and suggest research priorities. Methods A PubMed, Google Scholar, and Africa Journal Online (AJOL) literature search was conducted for studies on histoplasmosis in Africa between 2000 and 2020. Histoplasmosis essays in medical mycology textbooks were also consulted. This narrative review was prepared from the data gathered. Findings In the past 2 decades, histoplasmosis in general has seen a relative increase in case detection in some Africa countries, probably attributable to the gradually increasing medical mycology advocacy efforts in Africa. Histoplasmosis cases are dominated by African histoplasmosis mostly in Western and Central Africa, while classical histoplasmosis is more common in Southern and Northern Africa. Although both classical and African histoplasmosis are common in Africa, the latter is more restricted to Africa, and cases outside the continent usually have a travel history to the continent. Despite the clinical and laboratory difference between African histoplasmosis and classical histoplasmosis, it is not straightforward to distinguish them. The typical manifestation of African histoplasmosis is the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Bright K. Ocansey Chris Kosmidis Martin Agyei Améyo M. Dorkenoo Olusola O. Ayanlowo Rita O. Oladele Tchin Darre David W. Denning Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Histoplasmosis is a chronic granulomatous disease caused by the thermally dimorphic fungus Histoplasma capsulatum. The 2 variants Histoplasma capsulatum var. capsulatum (Hcc) and Histoplasma capsulatum var. duboisii (Hcd) causes infection in humans and commonly termed classical or American histoplasmosis and African histoplasmosis, respectively. Histoplasma capsulatum var. farciminosum (Hcf) affects equines. In recent times, there have been heightened sensitization on fungal infections such as histoplasmosis in Africa, aimed at improving awareness among relevant stakeholders, particularly healthcare workers. This effort is expected to be paralleled with increased detection of both classical and African histoplasmosis, which has remained underdiagnosed over the years. In this narrative review, we describe the current perspectives of histoplasmosis in Africa, identify knowledge gaps, and suggest research priorities. Methods A PubMed, Google Scholar, and Africa Journal Online (AJOL) literature search was conducted for studies on histoplasmosis in Africa between 2000 and 2020. Histoplasmosis essays in medical mycology textbooks were also consulted. This narrative review was prepared from the data gathered. Findings In the past 2 decades, histoplasmosis in general has seen a relative increase in case detection in some Africa countries, probably attributable to the gradually increasing medical mycology advocacy efforts in Africa. Histoplasmosis cases are dominated by African histoplasmosis mostly in Western and Central Africa, while classical histoplasmosis is more common in Southern and Northern Africa. Although both classical and African histoplasmosis are common in Africa, the latter is more restricted to Africa, and cases outside the continent usually have a travel history to the continent. Despite the clinical and laboratory difference between African histoplasmosis and classical histoplasmosis, it is not straightforward to distinguish them. The typical manifestation of African histoplasmosis is the ... |
format |
Article in Journal/Newspaper |
author |
Bright K. Ocansey Chris Kosmidis Martin Agyei Améyo M. Dorkenoo Olusola O. Ayanlowo Rita O. Oladele Tchin Darre David W. Denning |
author_facet |
Bright K. Ocansey Chris Kosmidis Martin Agyei Améyo M. Dorkenoo Olusola O. Ayanlowo Rita O. Oladele Tchin Darre David W. Denning |
author_sort |
Bright K. Ocansey |
title |
Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities |
title_short |
Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities |
title_full |
Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities |
title_fullStr |
Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities |
title_full_unstemmed |
Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities |
title_sort |
histoplasmosis in africa: current perspectives, knowledge gaps, and research priorities |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doaj.org/article/43b944ae32e7481ea1800b7d0fb32c87 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 2 (2022) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870498/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/43b944ae32e7481ea1800b7d0fb32c87 |
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1766342524701507584 |