Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage
The data on hepatitis A virus (HAV) seroprevalence are critical for the implementation of a universal mass vaccination (UMV) strategy. The latter has not been implemented in Russia; however, regional child vaccination programs have been adopted in some parts of the country. The aim of this study is...
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MDPI AG
2022
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Online Access: | https://doi.org/10.3390/vaccines10091423 https://doaj.org/article/434c34c1c76e4474bcc16cc90d72ca86 |
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ftdoajarticles:oai:doaj.org/article:434c34c1c76e4474bcc16cc90d72ca86 2023-05-15T18:45:00+02:00 Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage Karen K. Kyuregyan Maria A. Lopatukhina Fedor A. Asadi Mobarkhan Vera S. Kichatova Ilya A. Potemkin Olga V. Isaeva Anastasia A. Karlsen Elena Yu. Malinnikova Alla N. Kaira Tatyana V. Kozhanova Victor A. Manuylov Elena P. Mazunina Evgeniia N. Bykonia Denis A. Kleymenov Margarita E. Ignateva Olga E. Trotsenko Anna V. Kuznetsova Anna A. Saryglar Natalia D. Oorzhak Victor V. Romanenko Mikhail I. Mikhailov 2022-08-01T00:00:00Z https://doi.org/10.3390/vaccines10091423 https://doaj.org/article/434c34c1c76e4474bcc16cc90d72ca86 EN eng MDPI AG https://www.mdpi.com/2076-393X/10/9/1423 https://doaj.org/toc/2076-393X doi:10.3390/vaccines10091423 2076-393X https://doaj.org/article/434c34c1c76e4474bcc16cc90d72ca86 Vaccines, Vol 10, Iss 1423, p 1423 (2022) hepatitis A HAV herd immunity hepatitis A vaccination Medicine R article 2022 ftdoajarticles https://doi.org/10.3390/vaccines10091423 2022-12-30T21:57:44Z The data on hepatitis A virus (HAV) seroprevalence are critical for the implementation of a universal mass vaccination (UMV) strategy. The latter has not been implemented in Russia; however, regional child vaccination programs have been adopted in some parts of the country. The aim of this study is to assess changes in HAV immunity within the last decade in regions of Russia with different vaccination strategies and different vaccination coverage rates. In regions where UMV has not been implemented and HAV vaccination coverage rates do not exceed the national average, the 50% seroprevalence threshold has shifted in the Moscow region from people aged under 40 years in 2008 to people aged over 59 years in 2020, and from people aged under 30 years to people aged over 40 years in the Khabarovsk region. In two regions (Yakutia and Sverdlovsk), a two-dose-based UMV scheme has been in place since 2011 and 2003, respectively, and in Tuva single-dose child immunization was launched in 2012. These regional programs have resulted in a significant increase in HAV seroprevalence in children and adolescents. In Yakutia, 50% herd immunity had been achieved by 2020 in age groups under 20 years, compared to 20–30% seroprevalence rates in 2008. In the Sverdlovsk region, HAV immunity has increased to >65% over the decade in children aged over 10 years, adolescents and young adults, whereas it declined in older age groups. However, a three-fold drop in HAV immunity has occurred in children under 10 years of age, reflecting a significant decline in vaccination coverage. In Tuva, HAV immunity rates in children under 10 years old increased two-fold to exceed 50% by 2020. These data suggest that UMV should be implemented on a national level. Measures to control vaccination coverage and catch-up vaccination campaigns are recommended in order to maintain the effectiveness of existing HAV vaccination programs. Article in Journal/Newspaper Yakutia Directory of Open Access Journals: DOAJ Articles Tuva ENVELOPE(12.506,12.506,65.215,65.215) Vaccines 10 9 1423 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
hepatitis A HAV herd immunity hepatitis A vaccination Medicine R |
spellingShingle |
hepatitis A HAV herd immunity hepatitis A vaccination Medicine R Karen K. Kyuregyan Maria A. Lopatukhina Fedor A. Asadi Mobarkhan Vera S. Kichatova Ilya A. Potemkin Olga V. Isaeva Anastasia A. Karlsen Elena Yu. Malinnikova Alla N. Kaira Tatyana V. Kozhanova Victor A. Manuylov Elena P. Mazunina Evgeniia N. Bykonia Denis A. Kleymenov Margarita E. Ignateva Olga E. Trotsenko Anna V. Kuznetsova Anna A. Saryglar Natalia D. Oorzhak Victor V. Romanenko Mikhail I. Mikhailov Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage |
topic_facet |
hepatitis A HAV herd immunity hepatitis A vaccination Medicine R |
description |
The data on hepatitis A virus (HAV) seroprevalence are critical for the implementation of a universal mass vaccination (UMV) strategy. The latter has not been implemented in Russia; however, regional child vaccination programs have been adopted in some parts of the country. The aim of this study is to assess changes in HAV immunity within the last decade in regions of Russia with different vaccination strategies and different vaccination coverage rates. In regions where UMV has not been implemented and HAV vaccination coverage rates do not exceed the national average, the 50% seroprevalence threshold has shifted in the Moscow region from people aged under 40 years in 2008 to people aged over 59 years in 2020, and from people aged under 30 years to people aged over 40 years in the Khabarovsk region. In two regions (Yakutia and Sverdlovsk), a two-dose-based UMV scheme has been in place since 2011 and 2003, respectively, and in Tuva single-dose child immunization was launched in 2012. These regional programs have resulted in a significant increase in HAV seroprevalence in children and adolescents. In Yakutia, 50% herd immunity had been achieved by 2020 in age groups under 20 years, compared to 20–30% seroprevalence rates in 2008. In the Sverdlovsk region, HAV immunity has increased to >65% over the decade in children aged over 10 years, adolescents and young adults, whereas it declined in older age groups. However, a three-fold drop in HAV immunity has occurred in children under 10 years of age, reflecting a significant decline in vaccination coverage. In Tuva, HAV immunity rates in children under 10 years old increased two-fold to exceed 50% by 2020. These data suggest that UMV should be implemented on a national level. Measures to control vaccination coverage and catch-up vaccination campaigns are recommended in order to maintain the effectiveness of existing HAV vaccination programs. |
format |
Article in Journal/Newspaper |
author |
Karen K. Kyuregyan Maria A. Lopatukhina Fedor A. Asadi Mobarkhan Vera S. Kichatova Ilya A. Potemkin Olga V. Isaeva Anastasia A. Karlsen Elena Yu. Malinnikova Alla N. Kaira Tatyana V. Kozhanova Victor A. Manuylov Elena P. Mazunina Evgeniia N. Bykonia Denis A. Kleymenov Margarita E. Ignateva Olga E. Trotsenko Anna V. Kuznetsova Anna A. Saryglar Natalia D. Oorzhak Victor V. Romanenko Mikhail I. Mikhailov |
author_facet |
Karen K. Kyuregyan Maria A. Lopatukhina Fedor A. Asadi Mobarkhan Vera S. Kichatova Ilya A. Potemkin Olga V. Isaeva Anastasia A. Karlsen Elena Yu. Malinnikova Alla N. Kaira Tatyana V. Kozhanova Victor A. Manuylov Elena P. Mazunina Evgeniia N. Bykonia Denis A. Kleymenov Margarita E. Ignateva Olga E. Trotsenko Anna V. Kuznetsova Anna A. Saryglar Natalia D. Oorzhak Victor V. Romanenko Mikhail I. Mikhailov |
author_sort |
Karen K. Kyuregyan |
title |
Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage |
title_short |
Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage |
title_full |
Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage |
title_fullStr |
Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage |
title_full_unstemmed |
Dynamic Changes in Hepatitis A Immunity in Regions with Different Vaccination Strategies and Different Vaccination Coverage |
title_sort |
dynamic changes in hepatitis a immunity in regions with different vaccination strategies and different vaccination coverage |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/vaccines10091423 https://doaj.org/article/434c34c1c76e4474bcc16cc90d72ca86 |
long_lat |
ENVELOPE(12.506,12.506,65.215,65.215) |
geographic |
Tuva |
geographic_facet |
Tuva |
genre |
Yakutia |
genre_facet |
Yakutia |
op_source |
Vaccines, Vol 10, Iss 1423, p 1423 (2022) |
op_relation |
https://www.mdpi.com/2076-393X/10/9/1423 https://doaj.org/toc/2076-393X doi:10.3390/vaccines10091423 2076-393X https://doaj.org/article/434c34c1c76e4474bcc16cc90d72ca86 |
op_doi |
https://doi.org/10.3390/vaccines10091423 |
container_title |
Vaccines |
container_volume |
10 |
container_issue |
9 |
container_start_page |
1423 |
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1766235903404015616 |