Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study
Involvement of the digestive system in patients with acquired immunodeficiency syndrome (AIDS) is frequent and many changes in these patients are diagnosed only at autopsy. There are few studies of autopsy with detailed analysis of this system and only one was conducted in Brazil. We evaluated each...
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ftdoajarticles:oai:doaj.org/article:42e4802ebcf949cca57c5018784e71b9 2024-09-09T19:26:27+00:00 Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study Lucinda Calheiros Guimarães Ana Cristina Araujo Lemos Silva Adilha Misson Rua Micheletti Everton Nunes Melo Moura Mario Leon Silva-Vergara Sheila Jorge Adad 2012-04-01T00:00:00Z https://doi.org/10.1590/S0036-46652012000200006 https://doaj.org/article/42e4802ebcf949cca57c5018784e71b9 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652012000200006&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652012000200006 https://doaj.org/article/42e4802ebcf949cca57c5018784e71b9 Revista do Instituto de Medicina Tropical de São Paulo, Vol 54, Iss 2, Pp 89-94 (2012) Autopsy Pathology HIV Acquired Immunodeficiency Syndrome Digestive system Gastrointestinal tract Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1590/S0036-46652012000200006 2024-08-05T17:49:30Z Involvement of the digestive system in patients with acquired immunodeficiency syndrome (AIDS) is frequent and many changes in these patients are diagnosed only at autopsy. There are few studies of autopsy with detailed analysis of this system and only one was conducted in Brazil. We evaluated each segment of the digestive system in 93 consecutive autopsies of patients infected with human immunodeficiency virus (HIV) and the importance of these lesions to death. Of these, 90 (96.8%) patients had AIDS. We reviewed medical records, autopsy reports and histological sections from tongue to rectum stained with hematoxylin-eosin. When necessary, we analyzed special stains and immunohistochemistry to investigate infections. There was damage to the digestive system in 73 (78.5%) cases. The most common infections were candidiasis (42%), cytomegalovirus (29%), histoplasmosis (11.8%), toxoplasmosis (9.7%) and mycobacterial infection (9.7%). Malignancies were rare, present in four (4.3%) cases (two Kaposi's sarcoma, one adenocarcinoma and one metastatic embryonal carcinoma). All segments showed lesions: tongue (48.6%), esophagus (44.8%), stomach (44.7%), colon (43.2%) and small intestine (28.9%). The lesions found were immediate cause of death in five (5.4%) cases. In another 36 (38.7%) cases the basic disease was systemic and also compromised the digestive system. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 54 2 89 94 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Autopsy Pathology HIV Acquired Immunodeficiency Syndrome Digestive system Gastrointestinal tract Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Autopsy Pathology HIV Acquired Immunodeficiency Syndrome Digestive system Gastrointestinal tract Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Lucinda Calheiros Guimarães Ana Cristina Araujo Lemos Silva Adilha Misson Rua Micheletti Everton Nunes Melo Moura Mario Leon Silva-Vergara Sheila Jorge Adad Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study |
topic_facet |
Autopsy Pathology HIV Acquired Immunodeficiency Syndrome Digestive system Gastrointestinal tract Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Involvement of the digestive system in patients with acquired immunodeficiency syndrome (AIDS) is frequent and many changes in these patients are diagnosed only at autopsy. There are few studies of autopsy with detailed analysis of this system and only one was conducted in Brazil. We evaluated each segment of the digestive system in 93 consecutive autopsies of patients infected with human immunodeficiency virus (HIV) and the importance of these lesions to death. Of these, 90 (96.8%) patients had AIDS. We reviewed medical records, autopsy reports and histological sections from tongue to rectum stained with hematoxylin-eosin. When necessary, we analyzed special stains and immunohistochemistry to investigate infections. There was damage to the digestive system in 73 (78.5%) cases. The most common infections were candidiasis (42%), cytomegalovirus (29%), histoplasmosis (11.8%), toxoplasmosis (9.7%) and mycobacterial infection (9.7%). Malignancies were rare, present in four (4.3%) cases (two Kaposi's sarcoma, one adenocarcinoma and one metastatic embryonal carcinoma). All segments showed lesions: tongue (48.6%), esophagus (44.8%), stomach (44.7%), colon (43.2%) and small intestine (28.9%). The lesions found were immediate cause of death in five (5.4%) cases. In another 36 (38.7%) cases the basic disease was systemic and also compromised the digestive system. |
format |
Article in Journal/Newspaper |
author |
Lucinda Calheiros Guimarães Ana Cristina Araujo Lemos Silva Adilha Misson Rua Micheletti Everton Nunes Melo Moura Mario Leon Silva-Vergara Sheila Jorge Adad |
author_facet |
Lucinda Calheiros Guimarães Ana Cristina Araujo Lemos Silva Adilha Misson Rua Micheletti Everton Nunes Melo Moura Mario Leon Silva-Vergara Sheila Jorge Adad |
author_sort |
Lucinda Calheiros Guimarães |
title |
Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study |
title_short |
Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study |
title_full |
Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study |
title_fullStr |
Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study |
title_full_unstemmed |
Morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study |
title_sort |
morphological changes in the digestive system of 93 human immunodeficiency virus positive patients: an autopsy study |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2012 |
url |
https://doi.org/10.1590/S0036-46652012000200006 https://doaj.org/article/42e4802ebcf949cca57c5018784e71b9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 54, Iss 2, Pp 89-94 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652012000200006&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652012000200006 https://doaj.org/article/42e4802ebcf949cca57c5018784e71b9 |
op_doi |
https://doi.org/10.1590/S0036-46652012000200006 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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54 |
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2 |
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89 |
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94 |
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