TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups
Investigation of the frequencies of functionally signif icant gene variants in the context of medical biology and gene geography is a relevant issue for studying the genetic structure of human populations. The transition from a traditional to an urbanized lifestyle leads to a higher incidence of civ...
Published in: | Vavilov Journal of Genetics and Breeding |
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Language: | English Russian |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2022
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Online Access: | https://doi.org/10.18699/VJGB-22-23 https://doaj.org/article/426f7866ccee45e7823750df09f5ff19 |
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ftdoajarticles:oai:doaj.org/article:426f7866ccee45e7823750df09f5ff19 2024-02-11T10:09:25+01:00 TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups L. E. Tabikhanova L. P. Osipova T. V. Churkina E. N. Voronina M. L. Filipenko 2022-04-01T00:00:00Z https://doi.org/10.18699/VJGB-22-23 https://doaj.org/article/426f7866ccee45e7823750df09f5ff19 EN RU eng rus Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders https://vavilov.elpub.ru/jour/article/view/3295 https://doaj.org/toc/2500-3259 2500-3259 doi:10.18699/VJGB-22-23 https://doaj.org/article/426f7866ccee45e7823750df09f5ff19 Вавиловский журнал генетики и селекции, Vol 26, Iss 2, Pp 188-195 (2022) buryats teleuts yakuts dolgans russians from east siberia type 2 diabetes mellitus genetic polymorphism real-time pcr tcf7l2 (g103894t rs12255372) tcf7l2 (c53341t rs7903146) Genetics QH426-470 article 2022 ftdoajarticles https://doi.org/10.18699/VJGB-22-23 2024-01-14T01:50:16Z Investigation of the frequencies of functionally signif icant gene variants in the context of medical biology and gene geography is a relevant issue for studying the genetic structure of human populations. The transition from a traditional to an urbanized lifestyle leads to a higher incidence of civilizational diseases associated with metabolic disorders, including type 2 diabetes mellitus. The goal of the present paper is to analyze the frequencies of functionally signif icant gene alleles in the metabolic prof iles of indigenous Siberian peoples to identify the gene pool resilience, evaluate the susceptibility of various ethnic groups to metabolic disorders under changing environmental conditions, and predict the epidemiological situation that may occur in the near future. The study was performed in the monoethnic samples of eastern and western Buryats, Teleuts, Dolgans, and two territorial groups of Yakuts. A real-time PCR was used to determine the frequencies of single nucleotide polymorphisms (SNPs) G103894T, rs12255372, and C53341T, rs7903146 in the TCF7L2 gene. The results obtained were compared to the frequencies identif ied for Russians from Eastern Siberia and the values available in the literature. The frequencies of the polymorphic variants studied in the samples from the indigenous Siberian peoples place them in between Caucasian and East Asian populations, following the geographic gradient of polymorphism distribution. A signif icantly lower occurrence of type 2 diabetes risk alleles TCF7L2 (103894T) and TCF7L2 (53341T) in the samples of indigenous Siberian peoples compared to Russians was observed, which agrees with their lower susceptibility to metabolic disorders compared to the newcomer Caucasian population. Taking into account urbanization, a reduced growth in type 2 diabetes incidence may be predicted in indigenous Siberian peoples, i. e. Buryats, Yakuts, Dolgans, and Teleuts, compared to the newcomer Caucasian population. A further study of population structure with respect to different ... Article in Journal/Newspaper Yakuts Siberia Directory of Open Access Journals: DOAJ Articles Newcomer ENVELOPE(-58.100,-58.100,-62.025,-62.025) Vavilov Journal of Genetics and Breeding 26 2 188 195 |
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Directory of Open Access Journals: DOAJ Articles |
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English Russian |
topic |
buryats teleuts yakuts dolgans russians from east siberia type 2 diabetes mellitus genetic polymorphism real-time pcr tcf7l2 (g103894t rs12255372) tcf7l2 (c53341t rs7903146) Genetics QH426-470 |
spellingShingle |
buryats teleuts yakuts dolgans russians from east siberia type 2 diabetes mellitus genetic polymorphism real-time pcr tcf7l2 (g103894t rs12255372) tcf7l2 (c53341t rs7903146) Genetics QH426-470 L. E. Tabikhanova L. P. Osipova T. V. Churkina E. N. Voronina M. L. Filipenko TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups |
topic_facet |
buryats teleuts yakuts dolgans russians from east siberia type 2 diabetes mellitus genetic polymorphism real-time pcr tcf7l2 (g103894t rs12255372) tcf7l2 (c53341t rs7903146) Genetics QH426-470 |
description |
Investigation of the frequencies of functionally signif icant gene variants in the context of medical biology and gene geography is a relevant issue for studying the genetic structure of human populations. The transition from a traditional to an urbanized lifestyle leads to a higher incidence of civilizational diseases associated with metabolic disorders, including type 2 diabetes mellitus. The goal of the present paper is to analyze the frequencies of functionally signif icant gene alleles in the metabolic prof iles of indigenous Siberian peoples to identify the gene pool resilience, evaluate the susceptibility of various ethnic groups to metabolic disorders under changing environmental conditions, and predict the epidemiological situation that may occur in the near future. The study was performed in the monoethnic samples of eastern and western Buryats, Teleuts, Dolgans, and two territorial groups of Yakuts. A real-time PCR was used to determine the frequencies of single nucleotide polymorphisms (SNPs) G103894T, rs12255372, and C53341T, rs7903146 in the TCF7L2 gene. The results obtained were compared to the frequencies identif ied for Russians from Eastern Siberia and the values available in the literature. The frequencies of the polymorphic variants studied in the samples from the indigenous Siberian peoples place them in between Caucasian and East Asian populations, following the geographic gradient of polymorphism distribution. A signif icantly lower occurrence of type 2 diabetes risk alleles TCF7L2 (103894T) and TCF7L2 (53341T) in the samples of indigenous Siberian peoples compared to Russians was observed, which agrees with their lower susceptibility to metabolic disorders compared to the newcomer Caucasian population. Taking into account urbanization, a reduced growth in type 2 diabetes incidence may be predicted in indigenous Siberian peoples, i. e. Buryats, Yakuts, Dolgans, and Teleuts, compared to the newcomer Caucasian population. A further study of population structure with respect to different ... |
format |
Article in Journal/Newspaper |
author |
L. E. Tabikhanova L. P. Osipova T. V. Churkina E. N. Voronina M. L. Filipenko |
author_facet |
L. E. Tabikhanova L. P. Osipova T. V. Churkina E. N. Voronina M. L. Filipenko |
author_sort |
L. E. Tabikhanova |
title |
TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups |
title_short |
TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups |
title_full |
TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups |
title_fullStr |
TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups |
title_full_unstemmed |
TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups |
title_sort |
tcf7l2 gene polymorphism in populations of f ive siberian ethnic groups |
publisher |
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
publishDate |
2022 |
url |
https://doi.org/10.18699/VJGB-22-23 https://doaj.org/article/426f7866ccee45e7823750df09f5ff19 |
long_lat |
ENVELOPE(-58.100,-58.100,-62.025,-62.025) |
geographic |
Newcomer |
geographic_facet |
Newcomer |
genre |
Yakuts Siberia |
genre_facet |
Yakuts Siberia |
op_source |
Вавиловский журнал генетики и селекции, Vol 26, Iss 2, Pp 188-195 (2022) |
op_relation |
https://vavilov.elpub.ru/jour/article/view/3295 https://doaj.org/toc/2500-3259 2500-3259 doi:10.18699/VJGB-22-23 https://doaj.org/article/426f7866ccee45e7823750df09f5ff19 |
op_doi |
https://doi.org/10.18699/VJGB-22-23 |
container_title |
Vavilov Journal of Genetics and Breeding |
container_volume |
26 |
container_issue |
2 |
container_start_page |
188 |
op_container_end_page |
195 |
_version_ |
1790609315717971968 |