Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru.
Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal...
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ftdoajarticles:oai:doaj.org/article:4267698c5e0b409f873ce925d5104751 2023-05-15T15:07:25+02:00 Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru. Alexander S F Berry Renzo Salazar-Sánchez Ricardo Castillo-Neyra Katty Borrini-Mayorí Claudia Arevalo-Nieto Claudia Chipana-Ramos Melina Vargas-Maquera Jenny Ancca-Juarez César Náquira-Velarde Michael Z Levy Dustin Brisson 2020-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007910 https://doaj.org/article/4267698c5e0b409f873ce925d5104751 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007910 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007910 https://doaj.org/article/4267698c5e0b409f873ce925d5104751 PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0007910 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007910 2022-12-31T07:51:10Z Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal dynamics of hosts, vectors and pathogens of zoonotic disease systems. For example, a protozoan parasite and the causative agent of Chagas disease in humans, Trypanosoma cruzi, recently colonized and spread through the city of Arequipa, Peru. We used population genomic and phylogenomic tools to analyze whole genomes of 123 T. cruzi isolates derived from vectors and non-human mammals throughout Arequipa to determine patterns of T. cruzi dispersal. The data show significant population genetic structure within city blocks-parasites in the same block tend to be very closely related-but no population structure among blocks within districts-parasites in neighboring blocks are no more closely related to one another than to parasites in distant districts. These data suggest that T. cruzi dispersal within a block occurs regularly and that occasional long-range dispersal events allow the establishment of new T. cruzi populations in distant blocks. Movement of domestic animals may be the primary mechanism of inter-block and inter-district T. cruzi dispersal. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 3 e0007910 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Alexander S F Berry Renzo Salazar-Sánchez Ricardo Castillo-Neyra Katty Borrini-Mayorí Claudia Arevalo-Nieto Claudia Chipana-Ramos Melina Vargas-Maquera Jenny Ancca-Juarez César Náquira-Velarde Michael Z Levy Dustin Brisson Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal dynamics of hosts, vectors and pathogens of zoonotic disease systems. For example, a protozoan parasite and the causative agent of Chagas disease in humans, Trypanosoma cruzi, recently colonized and spread through the city of Arequipa, Peru. We used population genomic and phylogenomic tools to analyze whole genomes of 123 T. cruzi isolates derived from vectors and non-human mammals throughout Arequipa to determine patterns of T. cruzi dispersal. The data show significant population genetic structure within city blocks-parasites in the same block tend to be very closely related-but no population structure among blocks within districts-parasites in neighboring blocks are no more closely related to one another than to parasites in distant districts. These data suggest that T. cruzi dispersal within a block occurs regularly and that occasional long-range dispersal events allow the establishment of new T. cruzi populations in distant blocks. Movement of domestic animals may be the primary mechanism of inter-block and inter-district T. cruzi dispersal. |
format |
Article in Journal/Newspaper |
author |
Alexander S F Berry Renzo Salazar-Sánchez Ricardo Castillo-Neyra Katty Borrini-Mayorí Claudia Arevalo-Nieto Claudia Chipana-Ramos Melina Vargas-Maquera Jenny Ancca-Juarez César Náquira-Velarde Michael Z Levy Dustin Brisson |
author_facet |
Alexander S F Berry Renzo Salazar-Sánchez Ricardo Castillo-Neyra Katty Borrini-Mayorí Claudia Arevalo-Nieto Claudia Chipana-Ramos Melina Vargas-Maquera Jenny Ancca-Juarez César Náquira-Velarde Michael Z Levy Dustin Brisson |
author_sort |
Alexander S F Berry |
title |
Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru. |
title_short |
Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru. |
title_full |
Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru. |
title_fullStr |
Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru. |
title_full_unstemmed |
Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru. |
title_sort |
dispersal patterns of trypanosoma cruzi in arequipa, peru. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0007910 https://doaj.org/article/4267698c5e0b409f873ce925d5104751 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0007910 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007910 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007910 https://doaj.org/article/4267698c5e0b409f873ce925d5104751 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007910 |
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PLOS Neglected Tropical Diseases |
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14 |
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3 |
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e0007910 |
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