Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania.
Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, whic...
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ftdoajarticles:oai:doaj.org/article:424ea0ca74e54c548218e501b967cde8 2023-05-15T15:08:40+02:00 Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. Tereza Lestinova Iva Rohousova Michal Sima Camila I de Oliveira Petr Volf 2017-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005600 https://doaj.org/article/424ea0ca74e54c548218e501b967cde8 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5509103?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005600 https://doaj.org/article/424ea0ca74e54c548218e501b967cde8 PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005600 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005600 2022-12-31T15:00:28Z Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is composed of a diverse group of molecules with pharmacological and immunomodulatory properties.In this review, we focus on 3 main aspects of sand fly salivary molecules: (1) structure and composition of salivary glands, including the properties of salivary molecules related to hemostasis and blood feeding, (2) immunomodulatory properties of salivary molecules and the diverse impacts of these molecules on leishmaniasis, ranging from disease exacerbation to vaccine development, and (3) use of salivary molecules for field applications, including monitoring host exposure to sand flies and the risk of Leishmania transmission. Studies showed interesting differences between salivary proteins of Phlebotomus and Lutzomyia species, however, no data were ever published on salivary proteins of Sergentomyia species.In the last 15 years, numerous studies have characterized sand fly salivary proteins and, in parallel, have addressed the impact of such molecules on the biology of the host-sand fly-parasite interaction. The results obtained shall pave the way for the development of field-application tools that could contribute to the management of leishmaniasis in endemic areas. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 7 e0005600 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tereza Lestinova Iva Rohousova Michal Sima Camila I de Oliveira Petr Volf Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is composed of a diverse group of molecules with pharmacological and immunomodulatory properties.In this review, we focus on 3 main aspects of sand fly salivary molecules: (1) structure and composition of salivary glands, including the properties of salivary molecules related to hemostasis and blood feeding, (2) immunomodulatory properties of salivary molecules and the diverse impacts of these molecules on leishmaniasis, ranging from disease exacerbation to vaccine development, and (3) use of salivary molecules for field applications, including monitoring host exposure to sand flies and the risk of Leishmania transmission. Studies showed interesting differences between salivary proteins of Phlebotomus and Lutzomyia species, however, no data were ever published on salivary proteins of Sergentomyia species.In the last 15 years, numerous studies have characterized sand fly salivary proteins and, in parallel, have addressed the impact of such molecules on the biology of the host-sand fly-parasite interaction. The results obtained shall pave the way for the development of field-application tools that could contribute to the management of leishmaniasis in endemic areas. |
format |
Article in Journal/Newspaper |
author |
Tereza Lestinova Iva Rohousova Michal Sima Camila I de Oliveira Petr Volf |
author_facet |
Tereza Lestinova Iva Rohousova Michal Sima Camila I de Oliveira Petr Volf |
author_sort |
Tereza Lestinova |
title |
Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. |
title_short |
Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. |
title_full |
Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. |
title_fullStr |
Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. |
title_full_unstemmed |
Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. |
title_sort |
insights into the sand fly saliva: blood-feeding and immune interactions between sand flies, hosts, and leishmania. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005600 https://doaj.org/article/424ea0ca74e54c548218e501b967cde8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005600 (2017) |
op_relation |
http://europepmc.org/articles/PMC5509103?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005600 https://doaj.org/article/424ea0ca74e54c548218e501b967cde8 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005600 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
7 |
container_start_page |
e0005600 |
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1766339981580697600 |