Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis
Background and Aim. UDP-glucuronosyltransferases (UGTs) play an important role in drug metabolism and detoxification by catalyzing the glucuronidation reaction, which is associated with the occurrence of antituberculosis drug-induced liver injury (AT-DILI). The relationship between UGTs polymorphism...
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Hindawi Limited
2023
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ftdoajarticles:oai:doaj.org/article:424d3d2c80254d9192e4b4eb76877039 2023-11-12T04:13:58+01:00 Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis Xinyu Chen Zhuolu Hao Nannan Wang Jia Zhu Honggang Yi Shaowen Tang 2023-01-01T00:00:00Z https://doi.org/10.1155/2023/5044451 https://doaj.org/article/424d3d2c80254d9192e4b4eb76877039 EN eng Hindawi Limited http://dx.doi.org/10.1155/2023/5044451 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2023/5044451 https://doaj.org/article/424d3d2c80254d9192e4b4eb76877039 Journal of Tropical Medicine, Vol 2023 (2023) Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.1155/2023/5044451 2023-10-22T00:36:58Z Background and Aim. UDP-glucuronosyltransferases (UGTs) play an important role in drug metabolism and detoxification by catalyzing the glucuronidation reaction, which is associated with the occurrence of antituberculosis drug-induced liver injury (AT-DILI). The relationship between UGTs polymorphisms and AT-DILI risk has been reported but with inconsistent results. We conducted a systematic review and meta-analysis to summarize the previous study results and evaluate the precise relationships. Methods. The PRISMA statement was strictly followed, and the protocol was registered in PROSPERO (CRD42022339317). The PICOS framework was used: patients received antituberculosis treatment, UGTs polymorphisms (mutants), UGTs polymorphisms (wild), AT-DILI, and case-control studies. Eligible studies were searched through nine databases up to April 27, 2022. The study’s qualities were assessed by the revised Little’s recommendations. Meta-analysis was conducted with a random-effects model using odds ratios (ORs) with 95% confidence intervals (95% CIs) as the effect size. Results. Twelve case-control studies with 2128 cases and 4338 controls were included, and 32 single nucleotide polymorphisms (SNPs) in the seven UGT genes have been reported in Chinese and Korean. All studies were judged as high quality. The pooled results indicated that UGT1A1 rs3755319 (AC vs. AA, OR = 1.454, 95% CI: 1.100–1.921, P = 0.009), UGT2B7 rs7662029 (G vs. A, OR = 1.547, 95% CI: 1.249–1.917, P < 0.0001; GG + AG vs. AA, OR = 2.371, 95% CI: 1.779–3.160, P < 0.0001; AG vs. AA, OR = 2.686, 95% CI: 1.988–3.627, P < 0.0001), and UGT2B7 rs7439366 (C vs. T, OR = 0.585, 95% CI: 0.477–0.717, P < 0.0001; CC + TC vs. TT, OR = 0.347, 95% CI: 0.238–0.506, P < 0.0001; CC vs. TC + TT, OR = 0.675, 95% CI: 0.507–0.898, P = 0.007) might be associated with the risk of AT-DILI. Conclusions. The polymorphisms of UGT1A1 rs3755319, UGT2B7 rs7662029, and UGT2B7 rs7439366 were significantly associated with AT-DILI susceptibility. However, this conclusion ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) Journal of Tropical Medicine 2023 1 12 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Xinyu Chen Zhuolu Hao Nannan Wang Jia Zhu Honggang Yi Shaowen Tang Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Background and Aim. UDP-glucuronosyltransferases (UGTs) play an important role in drug metabolism and detoxification by catalyzing the glucuronidation reaction, which is associated with the occurrence of antituberculosis drug-induced liver injury (AT-DILI). The relationship between UGTs polymorphisms and AT-DILI risk has been reported but with inconsistent results. We conducted a systematic review and meta-analysis to summarize the previous study results and evaluate the precise relationships. Methods. The PRISMA statement was strictly followed, and the protocol was registered in PROSPERO (CRD42022339317). The PICOS framework was used: patients received antituberculosis treatment, UGTs polymorphisms (mutants), UGTs polymorphisms (wild), AT-DILI, and case-control studies. Eligible studies were searched through nine databases up to April 27, 2022. The study’s qualities were assessed by the revised Little’s recommendations. Meta-analysis was conducted with a random-effects model using odds ratios (ORs) with 95% confidence intervals (95% CIs) as the effect size. Results. Twelve case-control studies with 2128 cases and 4338 controls were included, and 32 single nucleotide polymorphisms (SNPs) in the seven UGT genes have been reported in Chinese and Korean. All studies were judged as high quality. The pooled results indicated that UGT1A1 rs3755319 (AC vs. AA, OR = 1.454, 95% CI: 1.100–1.921, P = 0.009), UGT2B7 rs7662029 (G vs. A, OR = 1.547, 95% CI: 1.249–1.917, P < 0.0001; GG + AG vs. AA, OR = 2.371, 95% CI: 1.779–3.160, P < 0.0001; AG vs. AA, OR = 2.686, 95% CI: 1.988–3.627, P < 0.0001), and UGT2B7 rs7439366 (C vs. T, OR = 0.585, 95% CI: 0.477–0.717, P < 0.0001; CC + TC vs. TT, OR = 0.347, 95% CI: 0.238–0.506, P < 0.0001; CC vs. TC + TT, OR = 0.675, 95% CI: 0.507–0.898, P = 0.007) might be associated with the risk of AT-DILI. Conclusions. The polymorphisms of UGT1A1 rs3755319, UGT2B7 rs7662029, and UGT2B7 rs7439366 were significantly associated with AT-DILI susceptibility. However, this conclusion ... |
format |
Article in Journal/Newspaper |
author |
Xinyu Chen Zhuolu Hao Nannan Wang Jia Zhu Honggang Yi Shaowen Tang |
author_facet |
Xinyu Chen Zhuolu Hao Nannan Wang Jia Zhu Honggang Yi Shaowen Tang |
author_sort |
Xinyu Chen |
title |
Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis |
title_short |
Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis |
title_full |
Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis |
title_fullStr |
Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis |
title_sort |
genetic polymorphisms of udp-glucuronosyltransferases and susceptibility to antituberculosis drug-induced liver injury: a systematic review and meta-analysis |
publisher |
Hindawi Limited |
publishDate |
2023 |
url |
https://doi.org/10.1155/2023/5044451 https://doaj.org/article/424d3d2c80254d9192e4b4eb76877039 |
long_lat |
ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Arctic Prisma |
geographic_facet |
Arctic Prisma |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2023 (2023) |
op_relation |
http://dx.doi.org/10.1155/2023/5044451 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2023/5044451 https://doaj.org/article/424d3d2c80254d9192e4b4eb76877039 |
op_doi |
https://doi.org/10.1155/2023/5044451 |
container_title |
Journal of Tropical Medicine |
container_volume |
2023 |
container_start_page |
1 |
op_container_end_page |
12 |
_version_ |
1782331742317707264 |