Rotavirus diarrhea disease burden in Peru: the need for a rotavirus vaccine and its potential cost savings
Objective. To assess the disease burden of rotavirus diarrhea in Peru as well the need for and the potential cost savings with a rotavirus vaccine in that country. Methods. To assess the burden of rotavirus diarrhea in Peru, we reviewed published and unpublished reports where rotavirus was sought as...
Published in: | Revista Panamericana de Salud Pública |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English Spanish Portuguese |
Published: |
Pan American Health Organization
2001
|
Subjects: | |
Online Access: | https://doi.org/10.1590/s1020-49892001001000004 https://doaj.org/article/4225659494e84db2896acb463f601f42 |
id |
ftdoajarticles:oai:doaj.org/article:4225659494e84db2896acb463f601f42 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:4225659494e84db2896acb463f601f42 2023-05-15T15:14:37+02:00 Rotavirus diarrhea disease burden in Peru: the need for a rotavirus vaccine and its potential cost savings Peter Ehrenkranz Claudio F. Lanata Mary E. Penny Eduardo Salazar-Lindo Roger I. Glass 2001-10-01T00:00:00Z https://doi.org/10.1590/s1020-49892001001000004 https://doaj.org/article/4225659494e84db2896acb463f601f42 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892001001000004&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 doi:10.1590/s1020-49892001001000004 https://doaj.org/article/4225659494e84db2896acb463f601f42 Revista Panamericana de Salud Pública, Vol 10, Iss 4, Pp 240-248 (2001) Rotavirus immunization diarrhea Peru cost-effectiveness Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2001 ftdoajarticles https://doi.org/10.1590/s1020-49892001001000004 2022-12-31T14:50:45Z Objective. To assess the disease burden of rotavirus diarrhea in Peru as well the need for and the potential cost savings with a rotavirus vaccine in that country. Methods. To assess the burden of rotavirus diarrhea in Peru, we reviewed published and unpublished reports where rotavirus was sought as the etiologic agent of diarrhea in children. Rotavirus detection rates obtained from these studies were combined with diarrhea incidence rates from a number of national surveys in order to estimate both the burden of rotavirus diarrhea in the country and its associated medical costs. Results. Rotavirus is a significant cause of morbidity and mortality in Peruvian children. In their first 5 years of life, an estimated 1 in 1.6 children will experience an episode of rotavirus diarrhea, 1 in 9.4 will seek medical care, 1 in 19.7 will require hospitalization, and 1 in 375 will die of the disease. Per year, this represents approximately 384 000 cases, 64 000 clinic visits, 30 000 hospitalizations, and 1 600 deaths. The annual cost of medical care alone for these children is approximately US$ 2.6 million--and that does not take into account the indirect or societal costs of the illness and the deaths. Conclusions. Rotavirus immunization provides the prospect of decreasing the morbidity and mortality from diarrhea in Peru, but a vaccine regimen would have to be relatively inexpensive, a few dollars or less per child. Future cost-effectiveness analyses should explore the total costs (medical as well as indirect or societal) associated with rotavirus diarrhea. Newly licensed vaccines should be tested according to both their ability to avert deaths and their efficacy with fewer than three doses. All three of these factors could increase the cost savings associated with a rotavirus vaccine. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud Pública 10 4 240 248 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Rotavirus immunization diarrhea Peru cost-effectiveness Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Rotavirus immunization diarrhea Peru cost-effectiveness Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Peter Ehrenkranz Claudio F. Lanata Mary E. Penny Eduardo Salazar-Lindo Roger I. Glass Rotavirus diarrhea disease burden in Peru: the need for a rotavirus vaccine and its potential cost savings |
topic_facet |
Rotavirus immunization diarrhea Peru cost-effectiveness Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Objective. To assess the disease burden of rotavirus diarrhea in Peru as well the need for and the potential cost savings with a rotavirus vaccine in that country. Methods. To assess the burden of rotavirus diarrhea in Peru, we reviewed published and unpublished reports where rotavirus was sought as the etiologic agent of diarrhea in children. Rotavirus detection rates obtained from these studies were combined with diarrhea incidence rates from a number of national surveys in order to estimate both the burden of rotavirus diarrhea in the country and its associated medical costs. Results. Rotavirus is a significant cause of morbidity and mortality in Peruvian children. In their first 5 years of life, an estimated 1 in 1.6 children will experience an episode of rotavirus diarrhea, 1 in 9.4 will seek medical care, 1 in 19.7 will require hospitalization, and 1 in 375 will die of the disease. Per year, this represents approximately 384 000 cases, 64 000 clinic visits, 30 000 hospitalizations, and 1 600 deaths. The annual cost of medical care alone for these children is approximately US$ 2.6 million--and that does not take into account the indirect or societal costs of the illness and the deaths. Conclusions. Rotavirus immunization provides the prospect of decreasing the morbidity and mortality from diarrhea in Peru, but a vaccine regimen would have to be relatively inexpensive, a few dollars or less per child. Future cost-effectiveness analyses should explore the total costs (medical as well as indirect or societal) associated with rotavirus diarrhea. Newly licensed vaccines should be tested according to both their ability to avert deaths and their efficacy with fewer than three doses. All three of these factors could increase the cost savings associated with a rotavirus vaccine. |
format |
Article in Journal/Newspaper |
author |
Peter Ehrenkranz Claudio F. Lanata Mary E. Penny Eduardo Salazar-Lindo Roger I. Glass |
author_facet |
Peter Ehrenkranz Claudio F. Lanata Mary E. Penny Eduardo Salazar-Lindo Roger I. Glass |
author_sort |
Peter Ehrenkranz |
title |
Rotavirus diarrhea disease burden in Peru: the need for a rotavirus vaccine and its potential cost savings |
title_short |
Rotavirus diarrhea disease burden in Peru: the need for a rotavirus vaccine and its potential cost savings |
title_full |
Rotavirus diarrhea disease burden in Peru: the need for a rotavirus vaccine and its potential cost savings |
title_fullStr |
Rotavirus diarrhea disease burden in Peru: the need for a rotavirus vaccine and its potential cost savings |
title_full_unstemmed |
Rotavirus diarrhea disease burden in Peru: the need for a rotavirus vaccine and its potential cost savings |
title_sort |
rotavirus diarrhea disease burden in peru: the need for a rotavirus vaccine and its potential cost savings |
publisher |
Pan American Health Organization |
publishDate |
2001 |
url |
https://doi.org/10.1590/s1020-49892001001000004 https://doaj.org/article/4225659494e84db2896acb463f601f42 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 10, Iss 4, Pp 240-248 (2001) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892001001000004&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 doi:10.1590/s1020-49892001001000004 https://doaj.org/article/4225659494e84db2896acb463f601f42 |
op_doi |
https://doi.org/10.1590/s1020-49892001001000004 |
container_title |
Revista Panamericana de Salud Pública |
container_volume |
10 |
container_issue |
4 |
container_start_page |
240 |
op_container_end_page |
248 |
_version_ |
1766345049563463680 |