Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model
Introduction: Pyrethroids have been frequently and intensively used for controlling the triatomine vectors of Trypanosoma cruzi. The emergence of resistance to these insecticides has resulted in an urgent need to identify novel, alternative and complementary control strategies. Objective: To evaluat...
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ftdoajarticles:oai:doaj.org/article:420d31710bff49e495c4e2ff37c38b26 2023-05-15T15:10:09+02:00 Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model Martín Dadé Martín Daniele Nora Mestorino 2017-09-01T00:00:00Z https://doi.org/10.7705/biomedica.v37i3.3316 https://doaj.org/article/420d31710bff49e495c4e2ff37c38b26 EN ES eng spa Instituto Nacional de Salud https://www.revistabiomedica.org/index.php/biomedica/article/view/3316 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v37i3.3316 https://doaj.org/article/420d31710bff49e495c4e2ff37c38b26 Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 3, Pp 324-332 (2017) Triatoma Trypanosoma cruzi Chagas disease insecticide resistance vector control ivermectin Wistar rats Medicine R Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.7705/biomedica.v37i3.3316 2022-12-30T23:45:28Z Introduction: Pyrethroids have been frequently and intensively used for controlling the triatomine vectors of Trypanosoma cruzi. The emergence of resistance to these insecticides has resulted in an urgent need to identify novel, alternative and complementary control strategies. Objective: To evaluate the toxic effects of ivermectin, doramectin and eprinomectin on the bloodfeeding behaviour of Triatoma infestans using a rodent model. Materials and methods: Fifth instar nymphs of T. infestans were fed at different times on Wistar rats pretreated with doramectin, ivermectin, eprinomectin or dimethylsulfoxide (excipient control) topically or orally administered. We determined the effects of each insecticide and of dimethyl sulfoxide on the amount of ingested blood, the volume of faecal discharge, and the mortality rates in triatomines. Results: Only the rate of triatomine mortality was associated with the antiparasitic compounds administered and the route of administration utilized. Doramectin administration was associated with a higher mortality rate (21.5%) than ivermectin, eprinomectin and dimethylsulfoxide (16, 11 and 2.5%, respectively), and topical administration was found to be most effective for inducing mortality (23 vs. 9.3 %). Conclusion: These results demonstrate the toxic effects of the three assessed insecticides on T. infestans. The administration of ecto/endoparasiticides to domiciliary or peridomiciliary animals may serve as an interesting complementary strategy to the use of pyrethroids for the control of T. infestans. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 37 3 324 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish |
topic |
Triatoma Trypanosoma cruzi Chagas disease insecticide resistance vector control ivermectin Wistar rats Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Triatoma Trypanosoma cruzi Chagas disease insecticide resistance vector control ivermectin Wistar rats Medicine R Arctic medicine. Tropical medicine RC955-962 Martín Dadé Martín Daniele Nora Mestorino Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model |
topic_facet |
Triatoma Trypanosoma cruzi Chagas disease insecticide resistance vector control ivermectin Wistar rats Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction: Pyrethroids have been frequently and intensively used for controlling the triatomine vectors of Trypanosoma cruzi. The emergence of resistance to these insecticides has resulted in an urgent need to identify novel, alternative and complementary control strategies. Objective: To evaluate the toxic effects of ivermectin, doramectin and eprinomectin on the bloodfeeding behaviour of Triatoma infestans using a rodent model. Materials and methods: Fifth instar nymphs of T. infestans were fed at different times on Wistar rats pretreated with doramectin, ivermectin, eprinomectin or dimethylsulfoxide (excipient control) topically or orally administered. We determined the effects of each insecticide and of dimethyl sulfoxide on the amount of ingested blood, the volume of faecal discharge, and the mortality rates in triatomines. Results: Only the rate of triatomine mortality was associated with the antiparasitic compounds administered and the route of administration utilized. Doramectin administration was associated with a higher mortality rate (21.5%) than ivermectin, eprinomectin and dimethylsulfoxide (16, 11 and 2.5%, respectively), and topical administration was found to be most effective for inducing mortality (23 vs. 9.3 %). Conclusion: These results demonstrate the toxic effects of the three assessed insecticides on T. infestans. The administration of ecto/endoparasiticides to domiciliary or peridomiciliary animals may serve as an interesting complementary strategy to the use of pyrethroids for the control of T. infestans. |
format |
Article in Journal/Newspaper |
author |
Martín Dadé Martín Daniele Nora Mestorino |
author_facet |
Martín Dadé Martín Daniele Nora Mestorino |
author_sort |
Martín Dadé |
title |
Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model |
title_short |
Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model |
title_full |
Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model |
title_fullStr |
Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model |
title_full_unstemmed |
Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model |
title_sort |
evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against triatoma infestans using a rat model |
publisher |
Instituto Nacional de Salud |
publishDate |
2017 |
url |
https://doi.org/10.7705/biomedica.v37i3.3316 https://doaj.org/article/420d31710bff49e495c4e2ff37c38b26 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 3, Pp 324-332 (2017) |
op_relation |
https://www.revistabiomedica.org/index.php/biomedica/article/view/3316 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v37i3.3316 https://doaj.org/article/420d31710bff49e495c4e2ff37c38b26 |
op_doi |
https://doi.org/10.7705/biomedica.v37i3.3316 |
container_title |
Biomédica |
container_volume |
37 |
container_issue |
3 |
container_start_page |
324 |
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1766341207498162176 |