Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure Diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva
We evaluated the in vitro phagocytic function and the production of microbicidal oxygen radicals by monocytes and neutrophils of 9 Chagas' heart disease subjects with heart failure and 9 without the syndrome in comparison with 11 healthy subjects, by assessing phagocytosis of Saccharomyces cere...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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2004
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ftdoajarticles:oai:doaj.org/article:4202bc49cea446d4a1ece08886d5751e 2023-05-15T15:17:33+02:00 Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure Diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva Maria Imaculada Muniz-Junqueira Lícia Maria Mota Rodrigo Barbosa Aires Luiz Fernando Junqueira Júnior 2004-12-01T00:00:00Z https://doi.org/10.1590/S0037-86822004000600004 https://doaj.org/article/4202bc49cea446d4a1ece08886d5751e EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000600004 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822004000600004 0037-8682 1678-9849 https://doaj.org/article/4202bc49cea446d4a1ece08886d5751e Revista da Sociedade Brasileira de Medicina Tropical, Vol 37, Iss 6, Pp 447-453 (2004) Cardiopatia chagásica Insuficiência cardíaca Fagocitose Teste do nitro blue tetrazolium Neutrófilos Monócitos Chagas' heart disease Cardiac failure Phagocytosis Nitro blue tetrazolium test Neutrophils Monocytes Arctic medicine. Tropical medicine RC955-962 article 2004 ftdoajarticles https://doi.org/10.1590/S0037-86822004000600004 2022-12-30T21:39:30Z We evaluated the in vitro phagocytic function and the production of microbicidal oxygen radicals by monocytes and neutrophils of 9 Chagas' heart disease subjects with heart failure and 9 without the syndrome in comparison with 11 healthy subjects, by assessing phagocytosis of Saccharomyces cerevisiae and NBT reduction by peripheral blood phagocytes. Phagocytic index of monocytes of chagasics without heart failure was significantly 6.7 and 10.6 times lower than those of controls and chagasics with the congestive syndrome, respectively, due to a lesser engagement in phagocytosis and to an inability of these cells to ingest particles. Neutrophils also show in chagasics without heart failure PI 11.2 and 19.8 times lower than that of controls and chagasics with heart failure, respectively. The percent of NBT reduction was normal and similar for the three groups. Balanced opposite effects of cardiovascular and immune disturbances may be acting in Chagas' disease subjects with heart failure paradoxically recovering the altered phagocytic function. A função fagocitária e a produção de radicais microbicidas de oxigênio pelos monócitos e neutrófilos foram avaliadas em 9 pacientes com cardiopatia chagásica com insuficiência cardíaca congestiva e 9 sem a síndrome em comparação com 11 indivíduos controles normais pelo teste de fagocitose de Saccharomyces cerevisiae e redução do nitroblue tetrazolium pelos fagócitos do sangue periférico. O índice fagocitário dos monócitos dos chagásicos sem insuficiência cardíaca foi significantemente 6,7 e 10,6 vezes menor do que o dos controles e chagásicos com a síndrome congestiva, respectivamente, devido ao menor envolvimento na fagocitose e a menor capacidade destas células de ingerirem partículas. Nos chagásicos sem insuficiência cardíaca os neutrófilos também apresentaram o IF 11,2 e 19,8 vezes menor que os controles e chagásicos com insuficiência cardíaca, respectivamente. A porcentagem de redução do NBT foi normal e similar para os três grupos. Efeitos opostos equilibrados das ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 37 6 447 453 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cardiopatia chagásica Insuficiência cardíaca Fagocitose Teste do nitro blue tetrazolium Neutrófilos Monócitos Chagas' heart disease Cardiac failure Phagocytosis Nitro blue tetrazolium test Neutrophils Monocytes Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Cardiopatia chagásica Insuficiência cardíaca Fagocitose Teste do nitro blue tetrazolium Neutrófilos Monócitos Chagas' heart disease Cardiac failure Phagocytosis Nitro blue tetrazolium test Neutrophils Monocytes Arctic medicine. Tropical medicine RC955-962 Maria Imaculada Muniz-Junqueira Lícia Maria Mota Rodrigo Barbosa Aires Luiz Fernando Junqueira Júnior Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure Diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva |
topic_facet |
Cardiopatia chagásica Insuficiência cardíaca Fagocitose Teste do nitro blue tetrazolium Neutrófilos Monócitos Chagas' heart disease Cardiac failure Phagocytosis Nitro blue tetrazolium test Neutrophils Monocytes Arctic medicine. Tropical medicine RC955-962 |
description |
We evaluated the in vitro phagocytic function and the production of microbicidal oxygen radicals by monocytes and neutrophils of 9 Chagas' heart disease subjects with heart failure and 9 without the syndrome in comparison with 11 healthy subjects, by assessing phagocytosis of Saccharomyces cerevisiae and NBT reduction by peripheral blood phagocytes. Phagocytic index of monocytes of chagasics without heart failure was significantly 6.7 and 10.6 times lower than those of controls and chagasics with the congestive syndrome, respectively, due to a lesser engagement in phagocytosis and to an inability of these cells to ingest particles. Neutrophils also show in chagasics without heart failure PI 11.2 and 19.8 times lower than that of controls and chagasics with heart failure, respectively. The percent of NBT reduction was normal and similar for the three groups. Balanced opposite effects of cardiovascular and immune disturbances may be acting in Chagas' disease subjects with heart failure paradoxically recovering the altered phagocytic function. A função fagocitária e a produção de radicais microbicidas de oxigênio pelos monócitos e neutrófilos foram avaliadas em 9 pacientes com cardiopatia chagásica com insuficiência cardíaca congestiva e 9 sem a síndrome em comparação com 11 indivíduos controles normais pelo teste de fagocitose de Saccharomyces cerevisiae e redução do nitroblue tetrazolium pelos fagócitos do sangue periférico. O índice fagocitário dos monócitos dos chagásicos sem insuficiência cardíaca foi significantemente 6,7 e 10,6 vezes menor do que o dos controles e chagásicos com a síndrome congestiva, respectivamente, devido ao menor envolvimento na fagocitose e a menor capacidade destas células de ingerirem partículas. Nos chagásicos sem insuficiência cardíaca os neutrófilos também apresentaram o IF 11,2 e 19,8 vezes menor que os controles e chagásicos com insuficiência cardíaca, respectivamente. A porcentagem de redução do NBT foi normal e similar para os três grupos. Efeitos opostos equilibrados das ... |
format |
Article in Journal/Newspaper |
author |
Maria Imaculada Muniz-Junqueira Lícia Maria Mota Rodrigo Barbosa Aires Luiz Fernando Junqueira Júnior |
author_facet |
Maria Imaculada Muniz-Junqueira Lícia Maria Mota Rodrigo Barbosa Aires Luiz Fernando Junqueira Júnior |
author_sort |
Maria Imaculada Muniz-Junqueira |
title |
Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure Diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva |
title_short |
Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure Diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva |
title_full |
Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure Diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva |
title_fullStr |
Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure Diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva |
title_full_unstemmed |
Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure Diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva |
title_sort |
differing phagocytic function of monocytes and neutrophils in chagas' cardiopathy according to the presence or absence of congestive heart failure diferenciada função de monócitos e neutrófilos na cardiopatia chagásica segundo a presença ou ausência de insuficiência cardíaca congestiva |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2004 |
url |
https://doi.org/10.1590/S0037-86822004000600004 https://doaj.org/article/4202bc49cea446d4a1ece08886d5751e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 37, Iss 6, Pp 447-453 (2004) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822004000600004 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822004000600004 0037-8682 1678-9849 https://doaj.org/article/4202bc49cea446d4a1ece08886d5751e |
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https://doi.org/10.1590/S0037-86822004000600004 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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37 |
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